The yellow fever 17D virus as a platform for new live attenuated vaccines

Detalhes bibliográficos
Autor(a) principal: Bonaldo, Myrna C.
Data de Publicação: 2014
Outros Autores: Sequeira, Patrícia C., Galler, Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31988
Resumo: Artigo disponível em acesso aberto na página do editor.
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spelling Bonaldo, Myrna C.Sequeira, Patrícia C.Galler, Ricardo2019-03-07T18:32:48Z2019-03-07T18:32:48Z2014BONALDO, Myrna C.; SEQUEIRA, Patrícia C.; GALLER, Ricardo. The yellow fever 17D virus as a platform for new live attenuated vaccines. Human Vaccines & Immunotherapeutics, v. 10, n. 5, p. 1256–1265, May 2014.2164-5515https://www.arca.fiocruz.br/handle/icict/3198810.4161/hv.28117Artigo disponível em acesso aberto na página do editor.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.The live-attenuated yellow fever 17D virus is one of the most outstanding human vaccines ever developed. It induces efficacious immune responses at a low production cost with a well-established manufacture process. These advantages make the YF17D virus attractive as a vector for the development of new vaccines. At the beginning of vector development studies, YF17D was genetically manipulated to express other flavivirus prM and E proteins, components of the viral envelope. While these 17D recombinants are based on the substitution of equivalent YF17D genes, other antigens from unrelated pathogens have also been successfully expressed and delivered by recombinant YF17D viruses employing alternative strategies for genetic manipulation of the YF17D genome. Herein, we discuss these strategies in terms of possibilities of single epitope or larger sequence expression and the main properties of these replication-competent viral platforms.engVírus da febre amarelaVacina 17DExpressão de genes estranhosVírus recombinantesDesenvolvimento de vacinasYellow fever virus17D vaccineRecombinant virusesVaccine developmentForeign gene expressionThe yellow fever 17D virus as a platform for new live attenuated vaccinesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/31988/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALF78-khvi-10-05-10928117.pdfapplication/pdf991006https://www.arca.fiocruz.br/bitstream/icict/31988/2/F78-khvi-10-05-10928117.pdfb83a4a03938492342a6006b8dd71660cMD52TEXTF78-khvi-10-05-10928117.pdf.txtF78-khvi-10-05-10928117.pdf.txtExtracted texttext/plain62172https://www.arca.fiocruz.br/bitstream/icict/31988/3/F78-khvi-10-05-10928117.pdf.txtffd4ddd7b953fc337a3ece4ce152af87MD53icict/319882019-04-04 02:05:02.533oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-04T05:05:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The yellow fever 17D virus as a platform for new live attenuated vaccines
title The yellow fever 17D virus as a platform for new live attenuated vaccines
spellingShingle The yellow fever 17D virus as a platform for new live attenuated vaccines
Bonaldo, Myrna C.
Vírus da febre amarela
Vacina 17D
Expressão de genes estranhos
Vírus recombinantes
Desenvolvimento de vacinas
Yellow fever virus
17D vaccine
Recombinant viruses
Vaccine development
Foreign gene expression
title_short The yellow fever 17D virus as a platform for new live attenuated vaccines
title_full The yellow fever 17D virus as a platform for new live attenuated vaccines
title_fullStr The yellow fever 17D virus as a platform for new live attenuated vaccines
title_full_unstemmed The yellow fever 17D virus as a platform for new live attenuated vaccines
title_sort The yellow fever 17D virus as a platform for new live attenuated vaccines
author Bonaldo, Myrna C.
author_facet Bonaldo, Myrna C.
Sequeira, Patrícia C.
Galler, Ricardo
author_role author
author2 Sequeira, Patrícia C.
Galler, Ricardo
author2_role author
author
dc.contributor.author.fl_str_mv Bonaldo, Myrna C.
Sequeira, Patrícia C.
Galler, Ricardo
dc.subject.other.pt_BR.fl_str_mv Vírus da febre amarela
Vacina 17D
Expressão de genes estranhos
Vírus recombinantes
Desenvolvimento de vacinas
topic Vírus da febre amarela
Vacina 17D
Expressão de genes estranhos
Vírus recombinantes
Desenvolvimento de vacinas
Yellow fever virus
17D vaccine
Recombinant viruses
Vaccine development
Foreign gene expression
dc.subject.en.pt_BR.fl_str_mv Yellow fever virus
17D vaccine
Recombinant viruses
Vaccine development
Foreign gene expression
description Artigo disponível em acesso aberto na página do editor.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-03-07T18:32:48Z
dc.date.available.fl_str_mv 2019-03-07T18:32:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONALDO, Myrna C.; SEQUEIRA, Patrícia C.; GALLER, Ricardo. The yellow fever 17D virus as a platform for new live attenuated vaccines. Human Vaccines & Immunotherapeutics, v. 10, n. 5, p. 1256–1265, May 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31988
dc.identifier.issn.pt_BR.fl_str_mv 2164-5515
dc.identifier.doi.none.fl_str_mv 10.4161/hv.28117
identifier_str_mv BONALDO, Myrna C.; SEQUEIRA, Patrícia C.; GALLER, Ricardo. The yellow fever 17D virus as a platform for new live attenuated vaccines. Human Vaccines & Immunotherapeutics, v. 10, n. 5, p. 1256–1265, May 2014.
2164-5515
10.4161/hv.28117
url https://www.arca.fiocruz.br/handle/icict/31988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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