Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation

Detalhes bibliográficos
Autor(a) principal: Erlandson, Kristine M
Data de Publicação: 2017
Outros Autores: Fiorillo, Suzanne P, Cardoso, Sandra Wagner, Riviere, Cynthia, Sanchez, Jorge, Hakim, James, Kumarasamy, Nagalingeswaran, Badal-Faesen, Sharlaa, Lalloo, Umesh, Kumwenda, Johnstone, Campbell, Thomas B, Brown, Todd T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25600
Resumo: 2018-09-30
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spelling Erlandson, Kristine MFiorillo, Suzanne PCardoso, Sandra WagnerRiviere, CynthiaSanchez, JorgeHakim, JamesKumarasamy, NagalingeswaranBadal-Faesen, SharlaaLalloo, UmeshKumwenda, JohnstoneCampbell, Thomas BBrown, Todd T2018-04-03T18:34:34Z2018-04-03T18:34:34Z2017ERLANDSON, Kristine M, et al. Insulin-like Growth Factor is Associated with Changes in Body Composition with ART Initiation. AIDS Research and Human Retroviruses, v. 33, n. 9, 2017.0889-2229https://www.arca.fiocruz.br/handle/icict/2560010.1089/AID.2016.0327engInsulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-09-30University of Colorado Denver, Aurora, CO, USAUniversity of Colorado Denver, Aurora, CO, USAFundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilLes Centres GHESKIO, Port-au-Prince, HaitiAsociación Civil Impacta Salud y Educación, Lima, Peru / University of Washington, Seattle, USAUniversity of Zimbabwe-College of Health Sciences, Harare, ZimbabweYRGCARE Medical Centre, CART CRS, Chennai, India.Clinical HIV Research Unit, Department of Medicine, University of Witwatersrand, Johannesburg, South AfricaDurban International Clinical Research Site, Durban, South AfricaCollege of Medicine- Johns Hopkins Project; Blantyre, MalawiUniversity of Colorado Denver; Aurora, CO, USAJohns Hopkins University, Baltimore, MD, USAGrowth hormone (GH)/insulin-like growth factor (IGF)-1 axis abnormalities have been associated with body composition changes among HIV-infected persons with wasting or lipodystrophy. Little is known of GH/IGF-1 axis alterations with antiretroviral therapy (ART) initiation or differing ART therapies. The AIDS Clinical Trials Group Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS) study was a prospective, randomized clinical trial of ART initiation with emtricitabine/tenofovir + efavirenz (FTC/TDF+EFV) versus lamivudine/zidovudine + efavirenz (3TC/ZDV+EFV) in HIV-1-infected individuals from resource-diverse settings. IGF-1 was measured from baseline, week 48, and week 96 stored serum samples. Multivariate models were constructed. 415 participants were included: 170 (41%) were randomized to FTC/TDF+EFV and 245 (59%) to 3TC/ZDV+EFV. The mean age was 35 years, 60% were black, 42% women. The mean IGF-1 level did not change significantly from baseline to week 96 (-0.65 ng/ml; 95% confidence interval (CI) -5.18-3.87), p = .78 and there were no differences by treatment arm at week 96, p = .74. Lower baseline IGF-1 was associated with age, non-white race, greater waist-hip ratio (WHR), low CD4 count, and lower baseline albumin (all p < .01) but not plasma HIV-1 RNA, body mass index, or treatment arm. Greater change in IGF-1 from baseline to 96 weeks was associated with female sex, smaller WHR change, lower baseline albumin, and higher baseline HIV-1 RNA (all p < .01). ART initiation with either ZDV or TDF did not significantly impact overall IGF-1 levels. Baseline and on-treatment changes in IGF-1 with ART initiation may be related to the body composition changes that occur after ART initiation.HIVAnthropomorphicsObesityLipodystrophyAntiretroviral therapyHighly activeInsulin-like growth factor-1info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/25600/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALve_Kristine_Erlandson_etal_INI_Lapclin_2017.pdfve_Kristine_Erlandson_etal_INI_Lapclin_2017.pdfapplication/pdf649392https://www.arca.fiocruz.br/bitstream/icict/25600/2/ve_Kristine_Erlandson_etal_INI_Lapclin_2017.pdfbba9c03d0769ed48d1c6aaa1694fd207MD52TEXTve_Kristine_Erlandson_etal_INI_Lapclin_2017.pdf.txtve_Kristine_Erlandson_etal_INI_Lapclin_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
title Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
spellingShingle Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
Erlandson, Kristine M
HIV
Anthropomorphics
Obesity
Lipodystrophy
Antiretroviral therapy
Highly active
Insulin-like growth factor-1
title_short Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
title_full Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
title_fullStr Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
title_full_unstemmed Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
title_sort Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
author Erlandson, Kristine M
author_facet Erlandson, Kristine M
Fiorillo, Suzanne P
Cardoso, Sandra Wagner
Riviere, Cynthia
Sanchez, Jorge
Hakim, James
Kumarasamy, Nagalingeswaran
Badal-Faesen, Sharlaa
Lalloo, Umesh
Kumwenda, Johnstone
Campbell, Thomas B
Brown, Todd T
author_role author
author2 Fiorillo, Suzanne P
Cardoso, Sandra Wagner
Riviere, Cynthia
Sanchez, Jorge
Hakim, James
Kumarasamy, Nagalingeswaran
Badal-Faesen, Sharlaa
Lalloo, Umesh
Kumwenda, Johnstone
Campbell, Thomas B
Brown, Todd T
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Erlandson, Kristine M
Fiorillo, Suzanne P
Cardoso, Sandra Wagner
Riviere, Cynthia
Sanchez, Jorge
Hakim, James
Kumarasamy, Nagalingeswaran
Badal-Faesen, Sharlaa
Lalloo, Umesh
Kumwenda, Johnstone
Campbell, Thomas B
Brown, Todd T
dc.subject.en.pt_BR.fl_str_mv HIV
Anthropomorphics
Obesity
Lipodystrophy
Antiretroviral therapy
Highly active
Insulin-like growth factor-1
topic HIV
Anthropomorphics
Obesity
Lipodystrophy
Antiretroviral therapy
Highly active
Insulin-like growth factor-1
description 2018-09-30
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-04-03T18:34:34Z
dc.date.available.fl_str_mv 2018-04-03T18:34:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ERLANDSON, Kristine M, et al. Insulin-like Growth Factor is Associated with Changes in Body Composition with ART Initiation. AIDS Research and Human Retroviruses, v. 33, n. 9, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25600
dc.identifier.issn.pt_BR.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/AID.2016.0327
identifier_str_mv ERLANDSON, Kristine M, et al. Insulin-like Growth Factor is Associated with Changes in Body Composition with ART Initiation. AIDS Research and Human Retroviruses, v. 33, n. 9, 2017.
0889-2229
10.1089/AID.2016.0327
url https://www.arca.fiocruz.br/handle/icict/25600
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/25600/3/ve_Kristine_Erlandson_etal_INI_Lapclin_2017.pdf.txt
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