Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus

Detalhes bibliográficos
Autor(a) principal: Alves, Crésio de Aragão Dantas
Data de Publicação: 2008
Outros Autores: Oliveira, Ana Claudia Sá, Brites, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6690
Resumo: p.342-348
id UFBA-2_2f9d3573143e46ccbce5d7ce037e2153
oai_identifier_str oai:repositorio.ufba.br:ri/6690
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Alves, Crésio de Aragão DantasOliveira, Ana Claudia SáBrites, CarlosAlves, Crésio de Aragão DantasOliveira, Ana Claudia SáBrites, Carlos2012-09-04T18:45:35Z2012-09-04T18:45:35Z2008-081413-8670http://www.repositorio.ufba.br/ri/handle/ri/6690v. 12, n. 4p.342-348The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohipertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohipertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some mechanisms have been described, including leptin and adiponectin deficiency, mitochondrial dysfunction and use of antiretroviral drugs. The type, dose and duration of the antiretroviral treatment, as well as age and puberty are the main risk factors. LS is also associated with increased incidence of cardiovascular illnesses, atherosclerosis and diabetes mellitus. Treatment includes physical activity, cautious restriction of caloric intake, changes in antiretroviral therapy, and use of insulin-sensitizing and lipid-lowering agents. Follow up must be periodic, consisting of measurement of body fat distribution, evaluation of the lipid profile and insulin resistance.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-04T18:45:35Z No. of bitstreams: 1 Alves, Crésio and Oliveira, Ana Cláudia.pdf: 52673 bytes, checksum: 0780a480fa28a9734c78458eb1bce349 (MD5)Made available in DSpace on 2012-09-04T18:45:35Z (GMT). No. of bitstreams: 1 Alves, Crésio and Oliveira, Ana Cláudia.pdf: 52673 bytes, checksum: 0780a480fa28a9734c78458eb1bce349 (MD5) Previous issue date: 2008-08SalvadorThe Brazilian Journal of Infectious Diseases and Contexto Publishinghttp://dx.doi.org/10.1590/S1413-86702008000400018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIVLipodystrophyHighly active antiretroviral treatmentChildren and adolescentsLipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virusBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALAlves, Crésio and Oliveira, Ana Cláudia.pdfAlves, Crésio and Oliveira, Ana Cláudia.pdfapplication/pdf52673https://repositorio.ufba.br/bitstream/ri/6690/1/Alves%2c%20Cr%c3%a9sio%20and%20Oliveira%2c%20Ana%20Cl%c3%a1udia.pdf0780a480fa28a9734c78458eb1bce349MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6690/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTAlves, Crésio and Oliveira, Ana Cláudia.pdf.txtAlves, Crésio and Oliveira, Ana Cláudia.pdf.txtExtracted texttext/plain41813https://repositorio.ufba.br/bitstream/ri/6690/3/Alves%2c%20Cr%c3%a9sio%20and%20Oliveira%2c%20Ana%20Cl%c3%a1udia.pdf.txt9f6a773bedfd1da10f8f6e028c6ad115MD53ri/66902022-07-05 14:03:23.159oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
spellingShingle Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
Alves, Crésio de Aragão Dantas
HIV
Lipodystrophy
Highly active antiretroviral treatment
Children and adolescents
title_short Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
title_full Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
title_fullStr Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
title_full_unstemmed Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
title_sort Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
author Alves, Crésio de Aragão Dantas
author_facet Alves, Crésio de Aragão Dantas
Oliveira, Ana Claudia Sá
Brites, Carlos
author_role author
author2 Oliveira, Ana Claudia Sá
Brites, Carlos
author2_role author
author
dc.contributor.author.fl_str_mv Alves, Crésio de Aragão Dantas
Oliveira, Ana Claudia Sá
Brites, Carlos
Alves, Crésio de Aragão Dantas
Oliveira, Ana Claudia Sá
Brites, Carlos
dc.subject.por.fl_str_mv HIV
Lipodystrophy
Highly active antiretroviral treatment
Children and adolescents
topic HIV
Lipodystrophy
Highly active antiretroviral treatment
Children and adolescents
description p.342-348
publishDate 2008
dc.date.issued.fl_str_mv 2008-08
dc.date.accessioned.fl_str_mv 2012-09-04T18:45:35Z
dc.date.available.fl_str_mv 2012-09-04T18:45:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6690
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 12, n. 4
identifier_str_mv 1413-8670
v. 12, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/6690
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702008000400018
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/6690/1/Alves%2c%20Cr%c3%a9sio%20and%20Oliveira%2c%20Ana%20Cl%c3%a1udia.pdf
https://repositorio.ufba.br/bitstream/ri/6690/2/license.txt
https://repositorio.ufba.br/bitstream/ri/6690/3/Alves%2c%20Cr%c3%a9sio%20and%20Oliveira%2c%20Ana%20Cl%c3%a1udia.pdf.txt
bitstream.checksum.fl_str_mv 0780a480fa28a9734c78458eb1bce349
1b89a9a0548218172d7c829f87a0eab9
9f6a773bedfd1da10f8f6e028c6ad115
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459405695385600

Registros relacionados