BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14711 |
Resumo: | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Bessa, Theolis Costa BarbosaArruda, Sérgio MarcosFernandes, Bruno DCarvalho, Lucas PedreiraCardoso, SilviaCunha, SérgioBarreto, Maurício LimaPereira, Susan MartinsRodrigues, Laura CBarral Netto, Manoel2016-06-30T18:04:02Z2016-07-07T11:39:48Z2016-06-30T18:04:02Z2016-07-07T11:39:48Z2003BARBOSA, T. et al. BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. Vaccine, v. 21, p. 2152–2160, May 2003.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/14711engElsevierBCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilLondon School of Hygiene and Tropical Medicine. London, UKFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilTuberculin skin test (TST) response and cytokine production in finger stab-derived whole blood cultures from 136 BCG scar-positive school-age children were evaluated before and after BCG revaccination. Fifty-four percent of the children increased in vitro production of IFN- after revaccination, and this increase was highly significant for previously unresponsive children (P < 0.0001). No correlation was found between TST response and cytokine production. Our data suggest that the in vitro IFN- response to mycobacterial antigens can be boosted by BCG revaccination and may contribute to the search of correlates of protection to be used for the evaluation of new mycobacterial vaccines.Immunological markersTuberculosis: immune response;IFNTNFIL-10info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBarbosa T BCG (Bacille of calmette....pdf.txtBarbosa T BCG (Bacille of calmette....pdf.txtExtracted texttext/plain40731https://www.arca.fiocruz.br/bitstream/icict/14711/4/Barbosa%20T%20BCG%20%28Bacille%20of%20calmette....pdf.txt89c94691d1be5b4591bd347734be77bcMD54ORIGINALBarbosa T BCG (Bacille of calmette....pdfapplication/pdf159799https://www.arca.fiocruz.br/bitstream/icict/14711/2/Barbosa%20T%20BCG%20%28Bacille%20of%20calmette....pdfd5493ee07a20994a05ae68dd94864329MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14711/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/147112023-03-15 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| dc.title.pt_BR.fl_str_mv |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| title |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| spellingShingle |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children Bessa, Theolis Costa Barbosa Immunological markers Tuberculosis: immune response; IFN TNF IL-10 |
| title_short |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| title_full |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| title_fullStr |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| title_full_unstemmed |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| title_sort |
BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children |
| author |
Bessa, Theolis Costa Barbosa |
| author_facet |
Bessa, Theolis Costa Barbosa Arruda, Sérgio Marcos Fernandes, Bruno D Carvalho, Lucas Pedreira Cardoso, Silvia Cunha, Sérgio Barreto, Maurício Lima Pereira, Susan Martins Rodrigues, Laura C Barral Netto, Manoel |
| author_role |
author |
| author2 |
Arruda, Sérgio Marcos Fernandes, Bruno D Carvalho, Lucas Pedreira Cardoso, Silvia Cunha, Sérgio Barreto, Maurício Lima Pereira, Susan Martins Rodrigues, Laura C Barral Netto, Manoel |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bessa, Theolis Costa Barbosa Arruda, Sérgio Marcos Fernandes, Bruno D Carvalho, Lucas Pedreira Cardoso, Silvia Cunha, Sérgio Barreto, Maurício Lima Pereira, Susan Martins Rodrigues, Laura C Barral Netto, Manoel |
| dc.subject.en.pt_BR.fl_str_mv |
Immunological markers Tuberculosis: immune response; IFN TNF IL-10 |
| topic |
Immunological markers Tuberculosis: immune response; IFN TNF IL-10 |
| description |
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2003 |
| dc.date.issued.fl_str_mv |
2003 |
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2016-06-30T18:04:02Z 2016-07-07T11:39:48Z |
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2016-06-30T18:04:02Z 2016-07-07T11:39:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BARBOSA, T. et al. BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. Vaccine, v. 21, p. 2152–2160, May 2003. |
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https://www.arca.fiocruz.br/handle/icict/14711 |
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0264-410X |
| identifier_str_mv |
BARBOSA, T. et al. BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. Vaccine, v. 21, p. 2152–2160, May 2003. 0264-410X |
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Elsevier |
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