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T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum

Detalhes bibliográficos
Autor(a) principal: Escobar, Sergio Cuervo
Data de Publicação: 2014
Outros Autores: Barragán, Monica Losada, Pérez, Adriana Umaña, Porrozzi, Renato, Vahia, Leonardo Saboia, Miranda, Luisa Helena Monteiro de, Morgado, Fernanda Nazaré, Menezes, Rodrigo Caldas, Gómez, Myriam Sánchez, Cuervo, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10646
Resumo: CNPq, Departamento Administrativo de Ciencia, Tecnología e Innovación, FIOCRUZ, National University of Colombia Research Council
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spelling Escobar, Sergio CuervoBarragán, Monica LosadaPérez, Adriana UmañaPorrozzi, RenatoVahia, Leonardo SaboiaMiranda, Luisa Helena Monteiro deMorgado, Fernanda NazaréMenezes, Rodrigo CaldasGómez, Myriam SánchezCuervo, Patricia2015-06-03T17:56:21Z2015-06-03T17:56:21Z2014ESCOBAR, Sergio Cuervo et al. T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum. Plos One, v.9, n.12, p.e114584, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1064610.1371/journal.pone.01145841932-6203CNPq, Departamento Administrativo de Ciencia, Tecnología e Innovación, FIOCRUZ, National University of Colombia Research CouncilUniversidad Nacional de Colombia. Laboratorio de Hormonas. Departamento de QuÍmica. Bogotá, ColômbiaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilUniversidad Nacional de Colombia. Laboratorio de Hormonas. Departamento de QuÍmica. Bogotá, ColômbiaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilUniversidad Nacional de Colombia. Laboratorio de Hormonas. Departamento de QuÍmica. Bogotá, ColômbiaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilVisceral leishmaniasis (VL) is a parasitic infectious disease that causes significant morbidity and mortality in the tropical and subtropical regions of the world. Although infections with visceralizing Leishmania may be asymptomatic, factors such as undernutrition increase the likelihood of progressing to clinical disease. Protein malnutrition, the most deleterious cause of malnutrition in developing countries, has been considered as a primary risk factor for the development of clinical VL. However, data regarding the immunological basis of this association are scarce. With the aim to analyze the effects of protein malnutrition on Leishmania infantum infection, we used BALB/c mice subjected to control or low protein isocaloric diets. Each animal group was divided into two subgroups and one was infected with L. infantum resulting in four study groups: animals fed 14% protein diet (CP), animals fed 4% protein diet (LP), animals fed 14% protein diet and infected (CPi), and animals fed 4% protein diet and infected (LPi).The susceptibility to L. infantum infection and immune responses were assessed in terms of body and lymphoid organ weight, parasite load, lymphocyte subpopulations, and cytokine expression. LPi mice had a significant reduction of body and lymphoid organ weight and exhibited a severe decrease of lymphoid follicles in the spleen. Moreover, LPi animals showed a significant decrease in CD4+CD8+ Tcells in the thymus, whereas there was an increase of CD4+ and CD8+ T cells percentages in the spleen. Notably, the cytokine mRNA levels in the thymus and spleen of protein malnourished-infected animals were altered compared to the CP mice. Protein malnutrition results in a drastic dysregulation of T cells and cytokine expression in the thymus and spleen of L. infantum-infected BALB/c mice, which may lead to defective regulation of the thymocyte population and an impaired splenic immune response, accelerating the events of a normal course of infection.engPublic Library of ScienceT-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmania infantumLeishmaniasis, VisceralAntigens, CD4Antigens, CD8Leishmania infantumLeishmaniose VisceralAntígenos CD4Antígenos CD8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
title T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
spellingShingle T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
Escobar, Sergio Cuervo
Leishmania infantum
Leishmaniasis, Visceral
Antigens, CD4
Antigens, CD8
Leishmania infantum
Leishmaniose Visceral
Antígenos CD4
Antígenos CD8
title_short T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
title_full T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
title_fullStr T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
title_full_unstemmed T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
title_sort T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
author Escobar, Sergio Cuervo
author_facet Escobar, Sergio Cuervo
Barragán, Monica Losada
Pérez, Adriana Umaña
Porrozzi, Renato
Vahia, Leonardo Saboia
Miranda, Luisa Helena Monteiro de
Morgado, Fernanda Nazaré
Menezes, Rodrigo Caldas
Gómez, Myriam Sánchez
Cuervo, Patricia
author_role author
author2 Barragán, Monica Losada
Pérez, Adriana Umaña
Porrozzi, Renato
Vahia, Leonardo Saboia
Miranda, Luisa Helena Monteiro de
Morgado, Fernanda Nazaré
Menezes, Rodrigo Caldas
Gómez, Myriam Sánchez
Cuervo, Patricia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Escobar, Sergio Cuervo
Barragán, Monica Losada
Pérez, Adriana Umaña
Porrozzi, Renato
Vahia, Leonardo Saboia
Miranda, Luisa Helena Monteiro de
Morgado, Fernanda Nazaré
Menezes, Rodrigo Caldas
Gómez, Myriam Sánchez
Cuervo, Patricia
dc.subject.en.pt_BR.fl_str_mv Leishmania infantum
Leishmaniasis, Visceral
Antigens, CD4
Antigens, CD8
topic Leishmania infantum
Leishmaniasis, Visceral
Antigens, CD4
Antigens, CD8
Leishmania infantum
Leishmaniose Visceral
Antígenos CD4
Antígenos CD8
dc.subject.decs.pt_BR.fl_str_mv Leishmania infantum
Leishmaniose Visceral
Antígenos CD4
Antígenos CD8
description CNPq, Departamento Administrativo de Ciencia, Tecnología e Innovación, FIOCRUZ, National University of Colombia Research Council
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-03T17:56:21Z
dc.date.available.fl_str_mv 2015-06-03T17:56:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESCOBAR, Sergio Cuervo et al. T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum. Plos One, v.9, n.12, p.e114584, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10646
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0114584
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv ESCOBAR, Sergio Cuervo et al. T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum. Plos One, v.9, n.12, p.e114584, 2014.
1932-6203
10.1371/journal.pone.0114584
url https://www.arca.fiocruz.br/handle/icict/10646
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10646/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/10646/2/T-Cell%20Populations%20and%20Cytokine%20Expression%20Are%20Impaired%20in%20Thymus%20and%20Spleen%20of%20Protein%20Malnourished%20BALBc%20Mice%20Infected%20with%20Leishmania%20infantum.pdf
https://www.arca.fiocruz.br/bitstream/icict/10646/3/T-Cell%20Populations%20and%20Cytokine%20Expression%20Are%20Impaired%20in%20Thymus%20and%20Spleen%20of%20Protein%20Malnourished%20BALBc%20Mice%20Infected%20with%20Leishmania%20infantum.pdf.txt
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