Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16158 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Rio de Janeiro, RJ, Brasil. |
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Silva, Camila Marques daChaves, Mariana M.Chaves, Suzana PassosFigliuolo, Vanessa RibeiroFernandes, José Roberto MeyerCorte-Real, SuzanaLameu, ClaudianaUlrich, HenningOjcius, David M.Bergmann, Bartira RossiSilva, Robson Coutinho2016-10-08T17:40:13Z2016-10-08T17:40:13Z2011SILVA, Camila Marques da; et al. Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis. Cellular Microbiology, v.13, n;9, p.1410-1428, 2011.1462-5814https://www.arca.fiocruz.br/handle/icict/1615810.1111/j.1462-5822.2011.01630.x1462-5822engWiley Online LibraryLeishmania amazonensisMacrófagosSusceptibilidade das células de acolhimentoApoptoseReceptor purinérgicoLeishmania amazonensismacrophagesapoptosishost-cell susceptibilitypurinergic receptorInfection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Laboratório de Imunofarmoclogia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Instituto Butantan. Centro de Toxinologia Aplicada - CAT-CEPID. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil.University of California. Research Institute and School of Natural Sciences. Merdec, CA, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofarmacologia. Rio de janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Rio de Janeiro, RJ, Brasil.Nucleotides are released into the extracellular milieu from infected cells and cells at inflammatory sites. The extracellular nucleotides bind to specific purinergic (P2) receptors and thereby induce a variety of cellular responses including anti-parasitic effects. Here we investigated whether extracellular nucleotides affect leishmanial infection in macrophages, and found that UTP reduces strongly the parasite load in peritoneal macrophages. Ultrastructural analysis of infected cells revealed that UTP induced morphological damage in the intracellular parasites. Uridine nucleotides also induced dose-dependent apoptosis of macrophages and production of ROI and RNI only in infected macrophages. The intracellular calcium measurements of infected cells showed that the response to UTP, but not UDP, increased the sensitivity and amplitude of cytosolic Ca(2+) changes. Infection of macrophages with Leishmania upregulated the expression of P2Y(2) and P2Y(4) receptor mRNA. The data suggest indirectly that Leishmania amazonensis infection induces modulation and heteromerization of P2Y receptors on macrophages. Thus UTP modulates the host response against L. amazonensis infection. UTP and UTP homologues should therefore be considered as novel components of therapeutic strategies against cutaneous leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16158/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALsuzana_cortereal_etal_IOC_2011.df.pdfsuzana_cortereal_etal_IOC_2011.df.pdfapplication/pdf1424487https://www.arca.fiocruz.br/bitstream/icict/16158/2/suzana_cortereal_etal_IOC_2011.df.pdfa4c4e0a455733877cd736ba3f87cf022MD52TEXTsuzana_cortereal_etal_IOC_2011.df.pdf.txtsuzana_cortereal_etal_IOC_2011.df.pdf.txtExtracted texttext/plain74089https://www.arca.fiocruz.br/bitstream/icict/16158/3/suzana_cortereal_etal_IOC_2011.df.pdf.txtfe67c89db18b83b516710549ecfbecfeMD53icict/161582018-04-02 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dc.title.pt_BR.fl_str_mv |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
title |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
spellingShingle |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis Silva, Camila Marques da Leishmania amazonensis Macrófagos Susceptibilidade das células de acolhimento Apoptose Receptor purinérgico Leishmania amazonensis macrophages apoptosis host-cell susceptibility purinergic receptor |
title_short |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
title_full |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
title_fullStr |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
title_full_unstemmed |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
title_sort |
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis |
author |
Silva, Camila Marques da |
author_facet |
Silva, Camila Marques da Chaves, Mariana M. Chaves, Suzana Passos Figliuolo, Vanessa Ribeiro Fernandes, José Roberto Meyer Corte-Real, Suzana Lameu, Claudiana Ulrich, Henning Ojcius, David M. Bergmann, Bartira Rossi Silva, Robson Coutinho |
author_role |
author |
author2 |
Chaves, Mariana M. Chaves, Suzana Passos Figliuolo, Vanessa Ribeiro Fernandes, José Roberto Meyer Corte-Real, Suzana Lameu, Claudiana Ulrich, Henning Ojcius, David M. Bergmann, Bartira Rossi Silva, Robson Coutinho |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Camila Marques da Chaves, Mariana M. Chaves, Suzana Passos Figliuolo, Vanessa Ribeiro Fernandes, José Roberto Meyer Corte-Real, Suzana Lameu, Claudiana Ulrich, Henning Ojcius, David M. Bergmann, Bartira Rossi Silva, Robson Coutinho |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania amazonensis Macrófagos Susceptibilidade das células de acolhimento Apoptose Receptor purinérgico |
topic |
Leishmania amazonensis Macrófagos Susceptibilidade das células de acolhimento Apoptose Receptor purinérgico Leishmania amazonensis macrophages apoptosis host-cell susceptibility purinergic receptor |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania amazonensis macrophages apoptosis host-cell susceptibility purinergic receptor |
description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofisiologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2016-10-08T17:40:13Z |
dc.date.available.fl_str_mv |
2016-10-08T17:40:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Camila Marques da; et al. Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis. Cellular Microbiology, v.13, n;9, p.1410-1428, 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/16158 |
dc.identifier.issn.pt_BR.fl_str_mv |
1462-5814 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1462-5822.2011.01630.x |
dc.identifier.eissn.none.fl_str_mv |
1462-5822 |
identifier_str_mv |
SILVA, Camila Marques da; et al. Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis. Cellular Microbiology, v.13, n;9, p.1410-1428, 2011. 1462-5814 10.1111/j.1462-5822.2011.01630.x 1462-5822 |
url |
https://www.arca.fiocruz.br/handle/icict/16158 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Wiley Online Library |
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Wiley Online Library |
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