Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Conceição, Maria José
Data de Publicação: 2008
Outros Autores: Lenzi, Henrique Leonel, Coura, José Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/4178
http://dx.doi.org/10.1016/j.actatropica.2008.05.007
Resumo: Universidade Federal do Rio de Janeiro. Hospital Clementino Fraga Filho. Departamento de Medicina Preventiva. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
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spelling Conceição, Maria JoséLenzi, Henrique LeonelCoura, José Rodrigues2012-07-18T15:13:53Z2012-07-18T15:13:53Z2008CONCEIÇÃO, M. J.; LENZI, H. L.; COURA, J. R. Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis. Acta Tropica, v.108, n.2-3, Nov.-Dec., 2008.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/4178http://dx.doi.org/10.1016/j.actatropica.2008.05.007engElsevierHuman study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Hospital Clementino Fraga Filho. Departamento de Medicina Preventiva. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Twenty Schistosoma mansoni strains were isolated from three groups of patients (intestinal, hepatointestinal and hepatosplenic clinical forms) born and living in the town of Capitão Andrade, Minas Gerais, Brazil. Schistosomal isolate from each group was inoculated into three sets of mice with 25, 50 and 100 cercariae. The animals were killed 90 and 180 days after infection and submitted to extensive histopathological study of the liver, lung, intestine and spleen to determine qualitative and quantitative morphological characteristics, mainly of the granulomas. The histopathological changes caused the same patterns of infection in mice and were proportional to the inoculum and the time of infection, confirming the relevance of quantitative aspects in the determination of the disease. These data indicate three possibilities: (1) mouse model is not adequate to predict possible differences in the S. mansoni isolates obtained from patients; (2) field isolates are probably genetic polymorphic and undifferentiated; (3) schistosomiasis in human does not depend on parasite intrinsic factors, but on multivariable factors, such as intensity and duration of infection, time of infection, age and gender and other characteristics such as host response.Schistosoma mansoniClinical formsStrainParasite burdenIsolatesGranulomaSchistosoma mansoni, patologiaGranuloma, parasitologiaVariação GenéticaGranuloma, patologiaIntestinos, patologiaBaço, patologiaSchistosoma mansoni, parasitologiaBaço, parasitologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
title Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
spellingShingle Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
Conceição, Maria José
Schistosoma mansoni
Clinical forms
Strain
Parasite burden
Isolates
Granuloma
Schistosoma mansoni, patologia
Granuloma, parasitologia
Variação Genética
Granuloma, patologia
Intestinos, patologia
Baço, patologia
Schistosoma mansoni, parasitologia
Baço, parasitologia
title_short Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
title_full Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
title_fullStr Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
title_full_unstemmed Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
title_sort Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis
author Conceição, Maria José
author_facet Conceição, Maria José
Lenzi, Henrique Leonel
Coura, José Rodrigues
author_role author
author2 Lenzi, Henrique Leonel
Coura, José Rodrigues
author2_role author
author
dc.contributor.author.fl_str_mv Conceição, Maria José
Lenzi, Henrique Leonel
Coura, José Rodrigues
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Clinical forms
Strain
Parasite burden
Isolates
Granuloma
topic Schistosoma mansoni
Clinical forms
Strain
Parasite burden
Isolates
Granuloma
Schistosoma mansoni, patologia
Granuloma, parasitologia
Variação Genética
Granuloma, patologia
Intestinos, patologia
Baço, patologia
Schistosoma mansoni, parasitologia
Baço, parasitologia
dc.subject.decs.pt_BR.fl_str_mv Schistosoma mansoni, patologia
Granuloma, parasitologia
Variação Genética
Granuloma, patologia
Intestinos, patologia
Baço, patologia
Schistosoma mansoni, parasitologia
Baço, parasitologia
description Universidade Federal do Rio de Janeiro. Hospital Clementino Fraga Filho. Departamento de Medicina Preventiva. Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-07-18T15:13:53Z
dc.date.available.fl_str_mv 2012-07-18T15:13:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CONCEIÇÃO, M. J.; LENZI, H. L.; COURA, J. R. Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis. Acta Tropica, v.108, n.2-3, Nov.-Dec., 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/4178
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1016/j.actatropica.2008.05.007
identifier_str_mv CONCEIÇÃO, M. J.; LENZI, H. L.; COURA, J. R. Human study and experimental behavior of Schistosoma mansoni isolates from patients with different clinical forms of schistosomiasis. Acta Tropica, v.108, n.2-3, Nov.-Dec., 2008.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/4178
http://dx.doi.org/10.1016/j.actatropica.2008.05.007
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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