Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Marcia
Data de Publicação: 2023
Outros Autores: Fanton, Susane, Paiva, Bruna R., Baptista, Beatriz G., Alvarenga, Livia, Ribeiro-Alves, Marcelo, Cardozo, Ludmila F. M. F., Mafra, Denise
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57506
Resumo: Marcia Ribeiro contributed to the data collection and analysis of samples and produced the figures, tables and writing. Susane Fanton and Beatriz Germer participated in data collection, randomisation and intervention. Bruna Paiva, Livia Alvarenga and Ludmila Cardozo actively contributed to analysing laboratory samples. Marcelo Ribeiro-Alves performed the statistical analysis; Denise Mafra coordinated the study and assisted in all stages of the research, restructured and revising the manuscript.
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spelling Ribeiro, MarciaFanton, SusanePaiva, Bruna R.Baptista, Beatriz G.Alvarenga, LiviaRibeiro-Alves, MarceloCardozo, Ludmila F. M. F.Mafra, Denise2023-03-23T01:24:52Z2023-03-23T01:24:52Z2023RIBEIRO, Marcia et al. Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis. Clinical Nutrition ESPEN, v. 53, p. 189-195, Feb. 2023.2405-4577https://www.arca.fiocruz.br/handle/icict/5750610.1016/j.clnesp.2022.12.009Marcia Ribeiro contributed to the data collection and analysis of samples and produced the figures, tables and writing. Susane Fanton and Beatriz Germer participated in data collection, randomisation and intervention. Bruna Paiva, Livia Alvarenga and Ludmila Cardozo actively contributed to analysing laboratory samples. Marcelo Ribeiro-Alves performed the statistical analysis; Denise Mafra coordinated the study and assisted in all stages of the research, restructured and revising the manuscript.This study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Graduate Program in Biological Sciences – Physiology. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil.Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. HIV/AIDS Clinical Research Center. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Fluminense Federal University. Graduate Program in Nutrition Sciences. Niterói, RJ, Brazil / Federal University of Rio de Janeiro. Graduate Program in Biological Sciences – Physiology. Rio de Janeiro, RJ, Brazil / Fluminense Federal University. Graduate Program in Medical Sciences. Niterói, RJ, Brazil.Background: Inflammation and oxidative stress lead to a high risk of cardiovascular disease in patients with chronic kidney disease (CKD). Food rich in polyphenols such as dark chocolate may be an effective strategy to mitigate inflammation and delay CKD complications, outwith sensorial pleasure promotion. The aim of this study was to evaluate the effects of dark chocolate on inflammation and oxidative stress markers in patients with CKD on hemodialysis (HD). Methods: A clinical trial was carried out with 59 patients who were allocated into the chocolate group [40g of dark chocolate (70% cocoa) offered during HD sessions, 3×/week] or the control group with any intervention for two months. Plasma levels of the inflammatory cytokines TNF-α and IL-6 were evaluated by the ELISA method. Thiobarbituric acid reactive substances such as malondialdehyde (MDA) and LDLox levels were evaluated as lipid peroxidation markers. Routine biochemical parameters were analysed using commercial BioClin® kits. Results: Thirty-five patients completed the chocolate group (18 men, 53.0 (16) years and 31.0 (39) months on HD) and 11 in the control group (7 men, 48.0 (17.5) years and 44.0 (56.5) months on HD). Regarding the differences between the groups, the patients who received dark chocolate had reduced plasma levels of TNF-α compared to the control (p = 0.008). No significant changes were observed in the oxidative stress parameters evaluated in both groups. Routine biochemical (including phosphorus and potassium levels) and anthropometric parameters and food intake were not changed after the study period. Conclusion: The intervention with dark chocolate (70% cocoa) for two months reduced the plasma levels of TNF-α in patients with CKD on HD. In addition, it is essential to emphasise that chocolate intake did not increase the plasma levels of phosphorus and potassium in these patients. This study was registered at clinicaltrials.gov as NCT04600258.engElsevierDark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChronic kidney diseaseHemodialysisInflammationOxidative stressDark chocolateinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57506/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Ribeiro_Marcia_etal_INI_2023.pdfve_Ribeiro_Marcia_etal_INI_2023.pdfapplication/pdf778323https://www.arca.fiocruz.br/bitstream/icict/57506/2/ve_Ribeiro_Marcia_etal_INI_2023.pdff0bd8e5cde842d9f98aaff990734d808MD52icict/575062023-03-22 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dc.title.en_US.fl_str_mv Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
title Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
spellingShingle Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
Ribeiro, Marcia
Chronic kidney disease
Hemodialysis
Inflammation
Oxidative stress
Dark chocolate
title_short Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
title_full Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
title_fullStr Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
title_full_unstemmed Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
title_sort Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis
author Ribeiro, Marcia
author_facet Ribeiro, Marcia
Fanton, Susane
Paiva, Bruna R.
Baptista, Beatriz G.
Alvarenga, Livia
Ribeiro-Alves, Marcelo
Cardozo, Ludmila F. M. F.
Mafra, Denise
author_role author
author2 Fanton, Susane
Paiva, Bruna R.
Baptista, Beatriz G.
Alvarenga, Livia
Ribeiro-Alves, Marcelo
Cardozo, Ludmila F. M. F.
Mafra, Denise
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Marcia
Fanton, Susane
Paiva, Bruna R.
Baptista, Beatriz G.
Alvarenga, Livia
Ribeiro-Alves, Marcelo
Cardozo, Ludmila F. M. F.
Mafra, Denise
dc.subject.en.en_US.fl_str_mv Chronic kidney disease
Hemodialysis
Inflammation
Oxidative stress
Dark chocolate
topic Chronic kidney disease
Hemodialysis
Inflammation
Oxidative stress
Dark chocolate
description Marcia Ribeiro contributed to the data collection and analysis of samples and produced the figures, tables and writing. Susane Fanton and Beatriz Germer participated in data collection, randomisation and intervention. Bruna Paiva, Livia Alvarenga and Ludmila Cardozo actively contributed to analysing laboratory samples. Marcelo Ribeiro-Alves performed the statistical analysis; Denise Mafra coordinated the study and assisted in all stages of the research, restructured and revising the manuscript.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-23T01:24:52Z
dc.date.available.fl_str_mv 2023-03-23T01:24:52Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO, Marcia et al. Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis. Clinical Nutrition ESPEN, v. 53, p. 189-195, Feb. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57506
dc.identifier.issn.en_US.fl_str_mv 2405-4577
dc.identifier.doi.none.fl_str_mv 10.1016/j.clnesp.2022.12.009
identifier_str_mv RIBEIRO, Marcia et al. Dark chocolate (70% cocoa) attenuates the inflammatory marker TNF-α in patients on hemodialysis. Clinical Nutrition ESPEN, v. 53, p. 189-195, Feb. 2023.
2405-4577
10.1016/j.clnesp.2022.12.009
url https://www.arca.fiocruz.br/handle/icict/57506
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/57506/2/ve_Ribeiro_Marcia_etal_INI_2023.pdf
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