Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Pereira, Polyana Silva
Data de Publicação: 2015
Outros Autores: Borghi, Miria, Araújo, Carlos Felipe Machado de, Aires, Caio Augusto Martins, Oliveira, Jane Cleide Ribeiro, Asensi, Marise Dutra, Assef, Ana Paula D’Alincourt Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13097
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
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spelling Pereira, Polyana SilvaBorghi, MiriaAraújo, Carlos Felipe Machado deAires, Caio Augusto MartinsOliveira, Jane Cleide RibeiroAsensi, Marise DutraAssef, Ana Paula D’Alincourt Carvalho2016-03-10T14:33:42Z2016-03-10T14:33:42Z2015PEREIRA, Polyana Silva; etal. Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil. Antimicrobial Agents and Chemotherapy, v.59, n.8, p.4453-4456, Aug. 2015.0066-4804https://www.arca.fiocruz.br/handle/icict/1309710.1128/AAC.04243-141098-6596engAmerican Society for MicrobiologyClonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Laboratório Central de Saúde Pública do Rio de Janeiro Noel Nutels. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Enzymes of the OXA-48 family have become some of the most important beta-lactamases in the world. A new OXA-48 variant (OXA-370) was first described for an Enterobacter hormaechei strain isolated in Rio Grande do Sul (southern region of Brazil) in 2013. Here we report detection of the blaOXA-370 gene in 24 isolates belonging to three Enterobacteriaceae species (22 Klebsiella pneumoniae isolates, 1 Enterobacter cloacae isolate, and 1 Enterobacter aerogenes isolate) collected from five hospitals in Rio de Janeiro, Brazil, in 2013 and 2014. The isolates showed a multidrug resistance profile, and 12.5% were resistant to polymyxin B. Besides blaOXA-370, no other carbapenemase genes were observed by PCR, whereas blaOXA-1 was found in all isolates and 22 isolates (91.6%) possessed blaCTX-M-15. Molecular typing of the K. pneumoniae isolates by pulsed-field gel electrophoresis (PFGE) showed the presence of two clonal groups, i.e., KpA (21 isolates) and KpB (1 isolate). KpA was characterized as sequence type 16 (ST16) and KpB as ST1041 by multilocus sequence typing (MLST). ST16 has been observed for KPC-producing K. pneumoniae in Rio de Janeiro. Plasmid analysis performed with six representative OXA-370-producing isolates showed plasmids harboring the blaOXA-370 gene in all strains, ranging from 25 kb to 150 kb. This study suggests that there is an urgent need to investigate the presence of OXA-370 and dissemination of the K. pneumoniae ST16 clone carrying this gene in Brazil.Clonal DisseminationOXA-370-ProducingKlebsiella pneumoniaeRio de JaneiroEnterobacteriaceaeKlebsiella pneumoniaebeta-LactamasesInfecções por Enterobacteriaceaeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13097/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmiria_borghi_etal_IOC_2015.pdfmiria_borghi_etal_IOC_2015.pdfapplication/pdf485495https://www.arca.fiocruz.br/bitstream/icict/13097/2/miria_borghi_etal_IOC_2015.pdfce068a779c016a17021c3615e301fe69MD52TEXTmiria_borghi_etal_IOC_2015.pdf.txtmiria_borghi_etal_IOC_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
title Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
spellingShingle Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
Pereira, Polyana Silva
Clonal Dissemination
OXA-370-Producing
Klebsiella pneumoniae
Rio de Janeiro
Enterobacteriaceae
Klebsiella pneumoniae
beta-Lactamases
Infecções por Enterobacteriaceae
title_short Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
title_full Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
title_fullStr Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
title_full_unstemmed Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
title_sort Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil
author Pereira, Polyana Silva
author_facet Pereira, Polyana Silva
Borghi, Miria
Araújo, Carlos Felipe Machado de
Aires, Caio Augusto Martins
Oliveira, Jane Cleide Ribeiro
Asensi, Marise Dutra
Assef, Ana Paula D’Alincourt Carvalho
author_role author
author2 Borghi, Miria
Araújo, Carlos Felipe Machado de
Aires, Caio Augusto Martins
Oliveira, Jane Cleide Ribeiro
Asensi, Marise Dutra
Assef, Ana Paula D’Alincourt Carvalho
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Polyana Silva
Borghi, Miria
Araújo, Carlos Felipe Machado de
Aires, Caio Augusto Martins
Oliveira, Jane Cleide Ribeiro
Asensi, Marise Dutra
Assef, Ana Paula D’Alincourt Carvalho
dc.subject.en.pt_BR.fl_str_mv Clonal Dissemination
OXA-370-Producing
Klebsiella pneumoniae
Rio de Janeiro
Enterobacteriaceae
topic Clonal Dissemination
OXA-370-Producing
Klebsiella pneumoniae
Rio de Janeiro
Enterobacteriaceae
Klebsiella pneumoniae
beta-Lactamases
Infecções por Enterobacteriaceae
dc.subject.decs.pt_BR.fl_str_mv Klebsiella pneumoniae
beta-Lactamases
Infecções por Enterobacteriaceae
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-10T14:33:42Z
dc.date.available.fl_str_mv 2016-03-10T14:33:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Polyana Silva; etal. Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil. Antimicrobial Agents and Chemotherapy, v.59, n.8, p.4453-4456, Aug. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13097
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.04243-14
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv PEREIRA, Polyana Silva; etal. Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil. Antimicrobial Agents and Chemotherapy, v.59, n.8, p.4453-4456, Aug. 2015.
0066-4804
10.1128/AAC.04243-14
1098-6596
url https://www.arca.fiocruz.br/handle/icict/13097
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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