Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.

Detalhes bibliográficos
Autor(a) principal: Miguel, Fúlvio Borges
Data de Publicação: 2006
Outros Autores: Cardoso, Ana Karina M. V, Barbosa Junior, Aryon de Almeida, Marcantonio Junior, Elcio, Goissis, Gilberto, Rosa, Fabiana Paim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12944
Resumo: Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil
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spelling Miguel, Fúlvio BorgesCardoso, Ana Karina M. VBarbosa Junior, Aryon de AlmeidaMarcantonio Junior, ElcioGoissis, GilbertoRosa, Fabiana Paim2016-03-02T17:55:09Z2016-03-02T17:55:09Z2006MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006.1552-4973https://www.arca.fiocruz.br/handle/icict/1294410.1002/jbm.b.30492engWileyMorphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilState Paulista University. Dentistry Faculty. Araraquara, SP, BrasilUniversity of São Paulo. Chemistry Department. São Carlos, SP, BrasilFederal University of Bahia. Health Sciences Institute. Salvador, BA, BrasilThe osteogenic behavior of three-dimensional collagenic and anionic matrices (M3DGA) implanted in critical bone defects of 8 mm diameter was morphologically assessed. The defects were performed in the calvaria of 48 adult male (Wistar) rats, and observed at days 15, 30, and 60. The animals were distributed in four groups of equal number: GA1 (M3DGA with 60 min of cross-linking in glutaraldehyde [GA]); GA2 (M3DGA with 30 min of cross-linking in GA); GA3 (M3DGA with 15 min of cross-linking in GA); and G4 (control group, without any implanted biomaterial). The M3DGAs were biocompatible, with mild and regressive chronic granulomatous inflammation, associated with the degradation of their fibers. Furthermore, tissue neovascularization and neomineralization was noted, with statistically significant differences in these amounts among the groups (GA1, GA2, and GA3) and G4. In G4 neoformation was limited to the edges of the defect as well as interstitial fibrosis. Under the experimental conditions and for the parameters analyzed, the M3DGAs had osteogenic behavior, which was more evident in M3DGA 15 minTissue bioengineeringAnionic collagenThree-dimensional matrixBone regenerationCritical size defectRegeneração ÓsseaSubstitutos ÓsseosCalcificação FisiológicaColágenoRegeneração Tecidual GuiadaNeovascularização FisiológicaAnimaisSubstitutos Ósseos/efeitos adversosColágeno/efeitos adversosTraumatismos Craniocerebrais/terapiaRegeneração Tecidual Guiada/efeitos adversosRatosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12944/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiguel FB Morphological....pdfMiguel FB Morphological....pdfapplication/pdf325372https://www.arca.fiocruz.br/bitstream/icict/12944/2/Miguel%20FB%20Morphological....pdff12705fbf204db47c344a63fd1f87c1cMD52TEXTMiguel FB Morphological....pdf.txtMiguel FB Morphological....pdf.txtExtracted texttext/plain23662https://www.arca.fiocruz.br/bitstream/icict/12944/3/Miguel%20FB%20Morphological....pdf.txt983597caf8a3e9e614d0982ec29ed1b8MD53icict/129442023-03-15 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dc.title.pt_BR.fl_str_mv Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
title Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
spellingShingle Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
Miguel, Fúlvio Borges
Tissue bioengineering
Anionic collagen
Three-dimensional matrix
Bone regeneration
Critical size defect
Regeneração Óssea
Substitutos Ósseos
Calcificação Fisiológica
Colágeno
Regeneração Tecidual Guiada
Neovascularização Fisiológica
Animais
Substitutos Ósseos/efeitos adversos
Colágeno/efeitos adversos
Traumatismos Craniocerebrais/terapia
Regeneração Tecidual Guiada/efeitos adversos
Ratos
title_short Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
title_full Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
title_fullStr Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
title_full_unstemmed Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
title_sort Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
author Miguel, Fúlvio Borges
author_facet Miguel, Fúlvio Borges
Cardoso, Ana Karina M. V
Barbosa Junior, Aryon de Almeida
Marcantonio Junior, Elcio
Goissis, Gilberto
Rosa, Fabiana Paim
author_role author
author2 Cardoso, Ana Karina M. V
Barbosa Junior, Aryon de Almeida
Marcantonio Junior, Elcio
Goissis, Gilberto
Rosa, Fabiana Paim
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Miguel, Fúlvio Borges
Cardoso, Ana Karina M. V
Barbosa Junior, Aryon de Almeida
Marcantonio Junior, Elcio
Goissis, Gilberto
Rosa, Fabiana Paim
dc.subject.en.pt_BR.fl_str_mv Tissue bioengineering
Anionic collagen
Three-dimensional matrix
Bone regeneration
Critical size defect
topic Tissue bioengineering
Anionic collagen
Three-dimensional matrix
Bone regeneration
Critical size defect
Regeneração Óssea
Substitutos Ósseos
Calcificação Fisiológica
Colágeno
Regeneração Tecidual Guiada
Neovascularização Fisiológica
Animais
Substitutos Ósseos/efeitos adversos
Colágeno/efeitos adversos
Traumatismos Craniocerebrais/terapia
Regeneração Tecidual Guiada/efeitos adversos
Ratos
dc.subject.decs.pt_BR.fl_str_mv Regeneração Óssea
Substitutos Ósseos
Calcificação Fisiológica
Colágeno
Regeneração Tecidual Guiada
Neovascularização Fisiológica
Animais
Substitutos Ósseos/efeitos adversos
Colágeno/efeitos adversos
Traumatismos Craniocerebrais/terapia
Regeneração Tecidual Guiada/efeitos adversos
Ratos
description Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2016-03-02T17:55:09Z
dc.date.available.fl_str_mv 2016-03-02T17:55:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12944
dc.identifier.issn.none.fl_str_mv 1552-4973
dc.identifier.doi.none.fl_str_mv 10.1002/jbm.b.30492
identifier_str_mv MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006.
1552-4973
10.1002/jbm.b.30492
url https://www.arca.fiocruz.br/handle/icict/12944
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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