Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12944 |
Resumo: | Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil |
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Miguel, Fúlvio BorgesCardoso, Ana Karina M. VBarbosa Junior, Aryon de AlmeidaMarcantonio Junior, ElcioGoissis, GilbertoRosa, Fabiana Paim2016-03-02T17:55:09Z2016-03-02T17:55:09Z2006MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006.1552-4973https://www.arca.fiocruz.br/handle/icict/1294410.1002/jbm.b.30492engWileyMorphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilState Paulista University. Dentistry Faculty. Araraquara, SP, BrasilUniversity of São Paulo. Chemistry Department. São Carlos, SP, BrasilFederal University of Bahia. Health Sciences Institute. Salvador, BA, BrasilThe osteogenic behavior of three-dimensional collagenic and anionic matrices (M3DGA) implanted in critical bone defects of 8 mm diameter was morphologically assessed. The defects were performed in the calvaria of 48 adult male (Wistar) rats, and observed at days 15, 30, and 60. The animals were distributed in four groups of equal number: GA1 (M3DGA with 60 min of cross-linking in glutaraldehyde [GA]); GA2 (M3DGA with 30 min of cross-linking in GA); GA3 (M3DGA with 15 min of cross-linking in GA); and G4 (control group, without any implanted biomaterial). The M3DGAs were biocompatible, with mild and regressive chronic granulomatous inflammation, associated with the degradation of their fibers. Furthermore, tissue neovascularization and neomineralization was noted, with statistically significant differences in these amounts among the groups (GA1, GA2, and GA3) and G4. In G4 neoformation was limited to the edges of the defect as well as interstitial fibrosis. Under the experimental conditions and for the parameters analyzed, the M3DGAs had osteogenic behavior, which was more evident in M3DGA 15 minTissue bioengineeringAnionic collagenThree-dimensional matrixBone regenerationCritical size defectRegeneração ÓsseaSubstitutos ÓsseosCalcificação FisiológicaColágenoRegeneração Tecidual GuiadaNeovascularização FisiológicaAnimaisSubstitutos Ósseos/efeitos adversosColágeno/efeitos adversosTraumatismos Craniocerebrais/terapiaRegeneração Tecidual Guiada/efeitos adversosRatosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12944/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiguel FB Morphological....pdfMiguel FB Morphological....pdfapplication/pdf325372https://www.arca.fiocruz.br/bitstream/icict/12944/2/Miguel%20FB%20Morphological....pdff12705fbf204db47c344a63fd1f87c1cMD52TEXTMiguel FB Morphological....pdf.txtMiguel FB Morphological....pdf.txtExtracted texttext/plain23662https://www.arca.fiocruz.br/bitstream/icict/12944/3/Miguel%20FB%20Morphological....pdf.txt983597caf8a3e9e614d0982ec29ed1b8MD53icict/129442023-03-15 14:33:08.519oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
title |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
spellingShingle |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Miguel, Fúlvio Borges Tissue bioengineering Anionic collagen Three-dimensional matrix Bone regeneration Critical size defect Regeneração Óssea Substitutos Ósseos Calcificação Fisiológica Colágeno Regeneração Tecidual Guiada Neovascularização Fisiológica Animais Substitutos Ósseos/efeitos adversos Colágeno/efeitos adversos Traumatismos Craniocerebrais/terapia Regeneração Tecidual Guiada/efeitos adversos Ratos |
title_short |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
title_full |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
title_fullStr |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
title_full_unstemmed |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
title_sort |
Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. |
author |
Miguel, Fúlvio Borges |
author_facet |
Miguel, Fúlvio Borges Cardoso, Ana Karina M. V Barbosa Junior, Aryon de Almeida Marcantonio Junior, Elcio Goissis, Gilberto Rosa, Fabiana Paim |
author_role |
author |
author2 |
Cardoso, Ana Karina M. V Barbosa Junior, Aryon de Almeida Marcantonio Junior, Elcio Goissis, Gilberto Rosa, Fabiana Paim |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Miguel, Fúlvio Borges Cardoso, Ana Karina M. V Barbosa Junior, Aryon de Almeida Marcantonio Junior, Elcio Goissis, Gilberto Rosa, Fabiana Paim |
dc.subject.en.pt_BR.fl_str_mv |
Tissue bioengineering Anionic collagen Three-dimensional matrix Bone regeneration Critical size defect |
topic |
Tissue bioengineering Anionic collagen Three-dimensional matrix Bone regeneration Critical size defect Regeneração Óssea Substitutos Ósseos Calcificação Fisiológica Colágeno Regeneração Tecidual Guiada Neovascularização Fisiológica Animais Substitutos Ósseos/efeitos adversos Colágeno/efeitos adversos Traumatismos Craniocerebrais/terapia Regeneração Tecidual Guiada/efeitos adversos Ratos |
dc.subject.decs.pt_BR.fl_str_mv |
Regeneração Óssea Substitutos Ósseos Calcificação Fisiológica Colágeno Regeneração Tecidual Guiada Neovascularização Fisiológica Animais Substitutos Ósseos/efeitos adversos Colágeno/efeitos adversos Traumatismos Craniocerebrais/terapia Regeneração Tecidual Guiada/efeitos adversos Ratos |
description |
Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2016-03-02T17:55:09Z |
dc.date.available.fl_str_mv |
2016-03-02T17:55:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/12944 |
dc.identifier.issn.none.fl_str_mv |
1552-4973 |
dc.identifier.doi.none.fl_str_mv |
10.1002/jbm.b.30492 |
identifier_str_mv |
MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006. 1552-4973 10.1002/jbm.b.30492 |
url |
https://www.arca.fiocruz.br/handle/icict/12944 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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