Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase

Detalhes bibliográficos
Autor(a) principal: Oliveira, Renato Antônio dos Santos
Data de Publicação: 2016
Outros Autores: Silva, Mayara Marques Carneiro da, Silva, Carlos Eduardo Calzavara, Silva, Ana Maria, Cordeiro, Marli Tenório, Moura, Patrícia Muniz Mendes Freire de, Baptista Filho, Paulo Neves, Marques Júnior, Ernesto Torres de Azevedo, Gonzales Gil, Laura Helena Vega
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19713
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.
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spelling Oliveira, Renato Antônio dos SantosSilva, Mayara Marques Carneiro daSilva, Carlos Eduardo CalzavaraSilva, Ana MariaCordeiro, Marli TenórioMoura, Patrícia Muniz Mendes Freire deBaptista Filho, Paulo NevesMarques Júnior, Ernesto Torres de AzevedoGonzales Gil, Laura Helena Vega2017-07-04T18:40:58Z2017-07-04T18:40:58Z2016OLIVEIRA, Renato Antônio dos Santos et al. Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 6. p. 378–384, 2016.0074-0276https://www.arca.fiocruz.br/handle/icict/1971310.1590/0074-02760150453porInstituto Oswaldo CruzDengue hemorragicodengue feverdengue haemorrhagic fevertype I interferoninnate immunityPrimary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Departamento de Imunologia, Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, BrasilUniversidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil / University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.Dengue is an acute febrile disease caused by the mosquito-borne dengue virus (DENV) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. Severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. In the present study we measured type I interferon (IFN-I) transcript and circulating levels in primary and secondary DENV infected patients. We observed that dengue fever (DF) and dengue haemorrhagic fever (DHF) patients express IFN-I differently. While DF and DHF patients express interferon-α similarly (52,71 ± 7,40 and 49,05 ± 7,70, respectively), IFN- β were associated with primary DHF patients. On the other hand, secondary DHF patients were not able to secrete large amounts of IFN- β which in turn may have influenced the high-level of viraemia. Our results suggest that, in patients from our cohort, infection by DENV serotype 3 elicits an innate response characterised by higher levels of IFN- β in the DHF patients with primary infection, which could contribute to control infection evidenced by the low-level of viraemia in these patients. The present findings may contribute to shed light in the role of innate immune response in dengue pathogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/19713/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALPrimary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-ß during acute phase.pdfPrimary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-ß during acute 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dc.title.pt_BR.fl_str_mv Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
title Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
spellingShingle Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
Oliveira, Renato Antônio dos Santos
Dengue hemorragico
dengue fever
dengue haemorrhagic fever
type I interferon
innate immunity
title_short Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
title_full Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
title_fullStr Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
title_full_unstemmed Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
title_sort Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
author Oliveira, Renato Antônio dos Santos
author_facet Oliveira, Renato Antônio dos Santos
Silva, Mayara Marques Carneiro da
Silva, Carlos Eduardo Calzavara
Silva, Ana Maria
Cordeiro, Marli Tenório
Moura, Patrícia Muniz Mendes Freire de
Baptista Filho, Paulo Neves
Marques Júnior, Ernesto Torres de Azevedo
Gonzales Gil, Laura Helena Vega
author_role author
author2 Silva, Mayara Marques Carneiro da
Silva, Carlos Eduardo Calzavara
Silva, Ana Maria
Cordeiro, Marli Tenório
Moura, Patrícia Muniz Mendes Freire de
Baptista Filho, Paulo Neves
Marques Júnior, Ernesto Torres de Azevedo
Gonzales Gil, Laura Helena Vega
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Renato Antônio dos Santos
Silva, Mayara Marques Carneiro da
Silva, Carlos Eduardo Calzavara
Silva, Ana Maria
Cordeiro, Marli Tenório
Moura, Patrícia Muniz Mendes Freire de
Baptista Filho, Paulo Neves
Marques Júnior, Ernesto Torres de Azevedo
Gonzales Gil, Laura Helena Vega
dc.subject.other.pt_BR.fl_str_mv Dengue hemorragico
topic Dengue hemorragico
dengue fever
dengue haemorrhagic fever
type I interferon
innate immunity
dc.subject.en.pt_BR.fl_str_mv dengue fever
dengue haemorrhagic fever
type I interferon
innate immunity
description Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia, Recife, PE, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-07-04T18:40:58Z
dc.date.available.fl_str_mv 2017-07-04T18:40:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Renato Antônio dos Santos et al. Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 6. p. 378–384, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19713
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760150453
identifier_str_mv OLIVEIRA, Renato Antônio dos Santos et al. Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 6. p. 378–384, 2016.
0074-0276
10.1590/0074-02760150453
url https://www.arca.fiocruz.br/handle/icict/19713
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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