HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population

Detalhes bibliográficos
Autor(a) principal: Monteiro,Sérgio Pereira
Data de Publicação: 2012
Outros Autores: Brasil,Pedro Emmanuel Alvarenga Americano do, Cabello,Giselda Maria Kalil, Souza,Rogério Valls de, Brasil,Patrícia, Georg,Ingebourg, Cabello,Pedro Hernan, De Castro,Liane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012
Resumo: Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLA-A*31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.
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spelling HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's populationdengue feverdengue haemorrhagic feverHLA-AHLA typingBrazilSevere forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLA-A*31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.Instituto Oswaldo Cruz, Ministério da Saúde2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012Memórias do Instituto Oswaldo Cruz v.107 n.2 2012reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762012000200012info:eu-repo/semantics/openAccessMonteiro,Sérgio PereiraBrasil,Pedro Emmanuel Alvarenga Americano doCabello,Giselda Maria KalilSouza,Rogério Valls deBrasil,PatríciaGeorg,IngebourgCabello,Pedro HernanDe Castro,Lianeeng2020-04-25T17:51:09Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:12.985Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
title HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
spellingShingle HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
Monteiro,Sérgio Pereira
dengue fever
dengue haemorrhagic fever
HLA-A
HLA typing
Brazil
title_short HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
title_full HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
title_fullStr HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
title_full_unstemmed HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
title_sort HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
author Monteiro,Sérgio Pereira
author_facet Monteiro,Sérgio Pereira
Brasil,Pedro Emmanuel Alvarenga Americano do
Cabello,Giselda Maria Kalil
Souza,Rogério Valls de
Brasil,Patrícia
Georg,Ingebourg
Cabello,Pedro Hernan
De Castro,Liane
author_role author
author2 Brasil,Pedro Emmanuel Alvarenga Americano do
Cabello,Giselda Maria Kalil
Souza,Rogério Valls de
Brasil,Patrícia
Georg,Ingebourg
Cabello,Pedro Hernan
De Castro,Liane
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro,Sérgio Pereira
Brasil,Pedro Emmanuel Alvarenga Americano do
Cabello,Giselda Maria Kalil
Souza,Rogério Valls de
Brasil,Patrícia
Georg,Ingebourg
Cabello,Pedro Hernan
De Castro,Liane
dc.subject.por.fl_str_mv dengue fever
dengue haemorrhagic fever
HLA-A
HLA typing
Brazil
topic dengue fever
dengue haemorrhagic fever
HLA-A
HLA typing
Brazil
dc.description.none.fl_txt_mv Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLA-A*31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.
description Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLA-A*31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762012000200012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.107 n.2 2012
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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