HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16740 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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Monteiro, Sérgio PereiraBrasil, Pedro Emmanuel Alvarenga Americano doCabello, Giselda Maria KalilSouza, Rogério Valls deBrasil, PatríciaGeorg, IngebourgCabello, Pedro HernanCastro, Liane de2017-01-05T17:04:22Z2017-01-05T17:04:22Z2012MONTEIRO, Sérgio Pereira et al. HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 2, p. 224-230, Mar. 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/1674010.1590/S0074-027620120002000121678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzDengueFebre hemorrágicaBrasilFebreDengue haemorrhagic feverDengue feverHLA-AHLA typingBrazilHLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host’s genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLAA* 31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16740/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgiselda_cabello_etal_IOC_2012.pdfgiselda_cabello_etal_IOC_2012.pdfapplication/pdf323613https://www.arca.fiocruz.br/bitstream/icict/16740/2/giselda_cabello_etal_IOC_2012.pdffa947b7beb22adf47a864a9c9d0a7372MD52TEXTgiselda_cabello_etal_IOC_2012.pdf.txtgiselda_cabello_etal_IOC_2012.pdf.txtExtracted texttext/plain40138https://www.arca.fiocruz.br/bitstream/icict/16740/3/giselda_cabello_etal_IOC_2012.pdf.txtb55ba1b330efe39e077796f309118d40MD53icict/167402019-10-22 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| dc.title.pt_BR.fl_str_mv |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| title |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| spellingShingle |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population Monteiro, Sérgio Pereira Dengue Febre hemorrágica Brasil Febre Dengue haemorrhagic fever Dengue fever HLA-A HLA typing Brazil |
| title_short |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| title_full |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| title_fullStr |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| title_full_unstemmed |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| title_sort |
HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population |
| author |
Monteiro, Sérgio Pereira |
| author_facet |
Monteiro, Sérgio Pereira Brasil, Pedro Emmanuel Alvarenga Americano do Cabello, Giselda Maria Kalil Souza, Rogério Valls de Brasil, Patrícia Georg, Ingebourg Cabello, Pedro Hernan Castro, Liane de |
| author_role |
author |
| author2 |
Brasil, Pedro Emmanuel Alvarenga Americano do Cabello, Giselda Maria Kalil Souza, Rogério Valls de Brasil, Patrícia Georg, Ingebourg Cabello, Pedro Hernan Castro, Liane de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Monteiro, Sérgio Pereira Brasil, Pedro Emmanuel Alvarenga Americano do Cabello, Giselda Maria Kalil Souza, Rogério Valls de Brasil, Patrícia Georg, Ingebourg Cabello, Pedro Hernan Castro, Liane de |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Febre hemorrágica Brasil Febre |
| topic |
Dengue Febre hemorrágica Brasil Febre Dengue haemorrhagic fever Dengue fever HLA-A HLA typing Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue haemorrhagic fever Dengue fever HLA-A HLA typing Brazil |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2012 |
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2012 |
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2017-01-05T17:04:22Z |
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2017-01-05T17:04:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MONTEIRO, Sérgio Pereira et al. HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 2, p. 224-230, Mar. 2012. |
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https://www.arca.fiocruz.br/handle/icict/16740 |
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0074-0276 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/S0074-02762012000200012 |
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1678-8060 |
| identifier_str_mv |
MONTEIRO, Sérgio Pereira et al. HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 2, p. 224-230, Mar. 2012. 0074-0276 10.1590/S0074-02762012000200012 1678-8060 |
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