NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55520 |
Resumo: | D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. |
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Moll-Bernardes, RenataFortier, Sérgio C.Sousa, Andréa S.Lopes, Renato D.Vera, NarendraConde, LucianaFeldman, AndréArruda, GuilhermeCabral-Castro, MauroAlbuquerque, Denílson C.Paula, Thiago C.Furquim, ThyagoLoures, Vitor A.Giusti, KarlaOliveira, NatháliaMacedo, ArianeSilva, Pedro Barros E.De Luca, FábioKotsugai, MarisolDomiciano, RafaelSilva, Flávia A.Santos, Mayara F.Souza, Olga F.Bozza, Fernando A.Luiz, Ronir R.Medei, Emiliano2022-11-07T19:20:33Z2022-11-07T19:20:33Z2022MOLL-BERNARDES, Renata et al. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. Journal of clinical medicine, v. 11, n. 13, p. 1-13, 20222077-0383https://www.arca.fiocruz.br/handle/icict/5552010.3390/jcm11133713engMDPINKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleD'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D'Or São Luiz. Pathological Anatomy Laboratory. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Duke University Medical Center. Duke Clinical Research Institute. Durham, NC, USA / Brazilian Clinical Research Institute. São Paulo, SP, Brazil.Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Anália Franco Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz São Caetano Hospital. São Caetano do Sul, SP, Brazil.Federal University of Rio de Janeiro. Institute of Microbiology Paulo de Góes. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rio de Janeiro State University. Cardiology Department. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Jabaquara Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Sino Brasileiro Hospital. Osasco, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Anália Franco Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Villa Lobos Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Villa Lobos Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Jabaquara Hospital. São Paulo, SP, Brazil / Santa Casa of São Paulo. São Paulo, SP, Brazil.Brazilian Clinical Research Institute. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Morumbi Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Morumbi Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / São Luiz Anália Franco Hospital. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D'Or São Luiz. Pathological Anatomy Laboratory. São Paulo, SP, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Copa Star Hospital. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Public Health Studies Institute. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. National Center for Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil.Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications.COVID-19HLA-DRNKG2AT cellHypertensionImmune responseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55520/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNKG2A_Andrea_Souza_etal_INI_2022.pdfNKG2A_Andrea_Souza_etal_INI_2022.pdfapplication/pdf821207https://www.arca.fiocruz.br/bitstream/icict/55520/2/NKG2A_Andrea_Souza_etal_INI_2022.pdf1978c0e63d807ae1834bbd66bd0f4520MD52icict/555202022-11-07 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| dc.title.en_US.fl_str_mv |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| spellingShingle |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial Moll-Bernardes, Renata COVID-19 HLA-DR NKG2A T cell Hypertension Immune response |
| title_short |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_full |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_fullStr |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_full_unstemmed |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_sort |
NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| author |
Moll-Bernardes, Renata |
| author_facet |
Moll-Bernardes, Renata Fortier, Sérgio C. Sousa, Andréa S. Lopes, Renato D. Vera, Narendra Conde, Luciana Feldman, André Arruda, Guilherme Cabral-Castro, Mauro Albuquerque, Denílson C. Paula, Thiago C. Furquim, Thyago Loures, Vitor A. Giusti, Karla Oliveira, Nathália Macedo, Ariane Silva, Pedro Barros E. De Luca, Fábio Kotsugai, Marisol Domiciano, Rafael Silva, Flávia A. Santos, Mayara F. Souza, Olga F. Bozza, Fernando A. Luiz, Ronir R. Medei, Emiliano |
| author_role |
author |
| author2 |
Fortier, Sérgio C. Sousa, Andréa S. Lopes, Renato D. Vera, Narendra Conde, Luciana Feldman, André Arruda, Guilherme Cabral-Castro, Mauro Albuquerque, Denílson C. Paula, Thiago C. Furquim, Thyago Loures, Vitor A. Giusti, Karla Oliveira, Nathália Macedo, Ariane Silva, Pedro Barros E. De Luca, Fábio Kotsugai, Marisol Domiciano, Rafael Silva, Flávia A. Santos, Mayara F. Souza, Olga F. Bozza, Fernando A. Luiz, Ronir R. Medei, Emiliano |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moll-Bernardes, Renata Fortier, Sérgio C. Sousa, Andréa S. Lopes, Renato D. Vera, Narendra Conde, Luciana Feldman, André Arruda, Guilherme Cabral-Castro, Mauro Albuquerque, Denílson C. Paula, Thiago C. Furquim, Thyago Loures, Vitor A. Giusti, Karla Oliveira, Nathália Macedo, Ariane Silva, Pedro Barros E. De Luca, Fábio Kotsugai, Marisol Domiciano, Rafael Silva, Flávia A. Santos, Mayara F. Souza, Olga F. Bozza, Fernando A. Luiz, Ronir R. Medei, Emiliano |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 HLA-DR NKG2A T cell Hypertension Immune response |
| topic |
COVID-19 HLA-DR NKG2A T cell Hypertension Immune response |
| description |
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. |
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2022 |
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2022-11-07T19:20:33Z |
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2022-11-07T19:20:33Z |
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2022 |
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info:eu-repo/semantics/article |
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MOLL-BERNARDES, Renata et al. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. Journal of clinical medicine, v. 11, n. 13, p. 1-13, 2022 |
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https://www.arca.fiocruz.br/handle/icict/55520 |
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2077-0383 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/jcm11133713 |
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MOLL-BERNARDES, Renata et al. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. Journal of clinical medicine, v. 11, n. 13, p. 1-13, 2022 2077-0383 10.3390/jcm11133713 |
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