Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60051 |
Resumo: | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil |
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Rego, Filipe Ferreira de AlmeidaMoraes, Laise deGiovanetti, MartaSilva, José Adriano GóesTorres, Felipe GuimarãesSilva, Marcio de OliveiraSilva, Maria da Purificação Pereira daWeyenbergh, Johan VanSantos, Luciane AmorimKhouri, Ricardo2023-08-11T18:59:38Z2023-08-11T18:59:38Z2023REGO, Filipe Ferreira de Almeida al. Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil. Viruses, v. 15, n. 8, p. 1650, 2023. doi.org/10.3390/v15081650.1999-4915https://www.arca.fiocruz.br/handle/icict/60051engMPDIGenomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrazilFundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico. Italy, RomeFundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brazil/Estado da Bahia. Secretaria Estadual de Saúde. Centro Estadual Especializado em Diagnóstico, Assistência e Pesquisa. Salvador, BA, BrazilFundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, BrazilEstado da Bahia. Secretaria Estadual de Saúde. Centro Estadual. Salvador, BA, BrazilEstado da Bahia. Secretaria Estadual de Saúde. Centro Estadual. Salvador, BA, BrazilRega Institute for Medical Research. Department of Immunology, Microbiology and Transplantation. KU Leuven. Leuven, BelgiumEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil/ Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, BrazilFundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brazil/Rega Institute for Medical Research. Department of Immunology, Microbiology and Transplantation. KU Leuven. Leuven, BelgiumBackground: The HIV subtype D is generally associated with a faster decline in CD4+ T cell counts, a higher viral load, and a faster progression to AIDS. However, it is still poorly characterized in Brazil. In this study, we used genomics and epidemiological data to investigate the transmission dynamics of HIV subtype D in the state of Bahia, Northeast Brazil. (2) Methods: To achieve this goal, we obtained four novel HIV-1 subtype D partial pol genome sequences using the Sanger method. To understand the emergence of this novel subtype in the state of Bahia, we used phylodynamic analysis on a dataset comprising 3704 pol genome sequences downloaded from the Los Alamos database. (3) Results: Our analysis revealed three branching patterns, indicating multiple introductions of the HIV-1 subtype D in Brazil from the late 1980s to the late 2000s and a single introduction event in the state of Bahia. Our data further suggest that these introductions most likely originated from European, Eastern African, Western African, and Southern African countries. (4) Conclusion: Understanding the distribution of HIV-1 viral strains and their temporal dynamics is crucial for monitoring the real-time evolution of circulating subtypes and recombinant forms, as well as for designing novel diagnostic and vaccination strategies. We advocate for a shift to active surveillance, to ensure adequate preparedness for future epidemics mediated by emerging viral strains.HIV-1 subtype Dphylodynamicsgenomic surveillanceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60051/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGenomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil.pdfGenomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil.pdfapplication/pdf655184https://www.arca.fiocruz.br/bitstream/icict/60051/2/Genomic%20Detection%20of%20the%20Emerging%2c%20Highly%20Pathogenic%20HIV-1%20Subtype%20D%20in%20Bahia%2c%20Northeast%20Brazil.pdfa1569af0fcbfc045f4b1e9f1edf775d7MD52icict/600512023-08-11 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| dc.title.en_US.fl_str_mv |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| title |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| spellingShingle |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil Rego, Filipe Ferreira de Almeida HIV-1 subtype D phylodynamics genomic surveillance |
| title_short |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| title_full |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| title_fullStr |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| title_full_unstemmed |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| title_sort |
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil |
| author |
Rego, Filipe Ferreira de Almeida |
| author_facet |
Rego, Filipe Ferreira de Almeida Moraes, Laise de Giovanetti, Marta Silva, José Adriano Góes Torres, Felipe Guimarães Silva, Marcio de Oliveira Silva, Maria da Purificação Pereira da Weyenbergh, Johan Van Santos, Luciane Amorim Khouri, Ricardo |
| author_role |
author |
| author2 |
Moraes, Laise de Giovanetti, Marta Silva, José Adriano Góes Torres, Felipe Guimarães Silva, Marcio de Oliveira Silva, Maria da Purificação Pereira da Weyenbergh, Johan Van Santos, Luciane Amorim Khouri, Ricardo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rego, Filipe Ferreira de Almeida Moraes, Laise de Giovanetti, Marta Silva, José Adriano Góes Torres, Felipe Guimarães Silva, Marcio de Oliveira Silva, Maria da Purificação Pereira da Weyenbergh, Johan Van Santos, Luciane Amorim Khouri, Ricardo |
| dc.subject.en.en_US.fl_str_mv |
HIV-1 subtype D phylodynamics genomic surveillance |
| topic |
HIV-1 subtype D phylodynamics genomic surveillance |
| description |
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil |
| publishDate |
2023 |
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2023-08-11T18:59:38Z |
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2023-08-11T18:59:38Z |
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2023 |
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REGO, Filipe Ferreira de Almeida al. Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil. Viruses, v. 15, n. 8, p. 1650, 2023. doi.org/10.3390/v15081650. |
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https://www.arca.fiocruz.br/handle/icict/60051 |
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1999-4915 |
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REGO, Filipe Ferreira de Almeida al. Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil. Viruses, v. 15, n. 8, p. 1650, 2023. doi.org/10.3390/v15081650. 1999-4915 |
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