PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases

Detalhes bibliográficos
Autor(a) principal: Carvalho, Márcia V. de
Data de Publicação: 2021
Outros Autores: Albuquerque, Cassiano F. Gonçalves de, Silva, Adriana R.
Tipo de documento: Artigo
Idioma: spa
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51050
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Carvalho, Márcia V. deAlbuquerque, Cassiano F. Gonçalves deSilva, Adriana R.2022-02-07T14:38:34Z2022-02-07T14:38:34Z2021CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021.1661-6596https://www.arca.fiocruz.br/handle/icict/5105010.3390/ijms220208051422-0067spaMDPILesão pulmonarDesconforto respiratório agudoInflamaçãoAlvos molecularesPPARYLung injuryAcute respiratory distressInflammationPPARYMolecular targetsPPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Programa de Pós-Graduação em Biologia Molecular e Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate the expression of genes related to lipid and glucose metabolism and inflammation. There are three members: PPAR , PPAR or PPAR . PPAR have several ligands. The natural agonists are omega 9, curcumin, eicosanoids and others. Among the synthetic ligands, we highlight the thiazolidinediones, clinically used as an antidiabetic. Many of these studies involve natural or synthetic products in different pathologies. The mechanisms that regulate PPAR involve post-translational modifications, such as phosphorylation, sumoylation and ubiquitination, among others. It is known that anti-inflammatory mechanisms involve the inhibition of other transcription factors, such as nuclear factor kB(NF B), signal transducer and activator of transcription (STAT) or activator protein 1 (AP-1), or intracellular signaling proteins such as mitogen-activated protein (MAP) kinases. PPAR transrepresses other transcription factors and consequently inhibits gene expression of inflammatory mediators, known as biomarkers for morbidity and mortality, leading to control of the exacerbated inflammation that occurs, for instance, in lung injury/acute respiratory distress. Many studies have shown the therapeutic potentials of PPAR on pulmonary diseases. Herein, we describe activities of the PPAR as a modulator of inflammation, focusing on lung injury and including definition and mechanisms of regulation, biological effects and molecular targets, and its role in lung diseases caused by inflammatory stimuli, bacteria and virus, and molecularbased therapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51050/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdfMarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdfapplication/pdf1439702https://www.arca.fiocruz.br/bitstream/icict/51050/2/MarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdf6dbad8e4b09b68142ca968a36b393be8MD52icict/510502022-02-07 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dc.title.pt_BR.fl_str_mv PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
spellingShingle PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
Carvalho, Márcia V. de
Lesão pulmonar
Desconforto respiratório agudo
Inflamação
Alvos moleculares
PPARY
Lung injury
Acute respiratory distress
Inflammation
PPARY
Molecular targets
title_short PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_full PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_fullStr PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_full_unstemmed PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
title_sort PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
author Carvalho, Márcia V. de
author_facet Carvalho, Márcia V. de
Albuquerque, Cassiano F. Gonçalves de
Silva, Adriana R.
author_role author
author2 Albuquerque, Cassiano F. Gonçalves de
Silva, Adriana R.
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Márcia V. de
Albuquerque, Cassiano F. Gonçalves de
Silva, Adriana R.
dc.subject.other.pt_BR.fl_str_mv Lesão pulmonar
Desconforto respiratório agudo
Inflamação
Alvos moleculares
PPARY
topic Lesão pulmonar
Desconforto respiratório agudo
Inflamação
Alvos moleculares
PPARY
Lung injury
Acute respiratory distress
Inflammation
PPARY
Molecular targets
dc.subject.en.pt_BR.fl_str_mv Lung injury
Acute respiratory distress
Inflammation
PPARY
Molecular targets
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-07T14:38:34Z
dc.date.available.fl_str_mv 2022-02-07T14:38:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51050
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms22020805
dc.identifier.eissn.none.fl_str_mv 1422-0067
identifier_str_mv CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021.
1661-6596
10.3390/ijms22020805
1422-0067
url https://www.arca.fiocruz.br/handle/icict/51050
dc.language.iso.fl_str_mv spa
language spa
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51050/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51050/2/MarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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