PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51050 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil. |
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Carvalho, Márcia V. deAlbuquerque, Cassiano F. Gonçalves deSilva, Adriana R.2022-02-07T14:38:34Z2022-02-07T14:38:34Z2021CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021.1661-6596https://www.arca.fiocruz.br/handle/icict/5105010.3390/ijms220208051422-0067spaMDPILesão pulmonarDesconforto respiratório agudoInflamaçãoAlvos molecularesPPARYLung injuryAcute respiratory distressInflammationPPARYMolecular targetsPPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Programa de Pós-Graduação em Biologia Molecular e Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate the expression of genes related to lipid and glucose metabolism and inflammation. There are three members: PPAR , PPAR or PPAR . PPAR have several ligands. The natural agonists are omega 9, curcumin, eicosanoids and others. Among the synthetic ligands, we highlight the thiazolidinediones, clinically used as an antidiabetic. Many of these studies involve natural or synthetic products in different pathologies. The mechanisms that regulate PPAR involve post-translational modifications, such as phosphorylation, sumoylation and ubiquitination, among others. It is known that anti-inflammatory mechanisms involve the inhibition of other transcription factors, such as nuclear factor kB(NF B), signal transducer and activator of transcription (STAT) or activator protein 1 (AP-1), or intracellular signaling proteins such as mitogen-activated protein (MAP) kinases. PPAR transrepresses other transcription factors and consequently inhibits gene expression of inflammatory mediators, known as biomarkers for morbidity and mortality, leading to control of the exacerbated inflammation that occurs, for instance, in lung injury/acute respiratory distress. Many studies have shown the therapeutic potentials of PPAR on pulmonary diseases. Herein, we describe activities of the PPAR as a modulator of inflammation, focusing on lung injury and including definition and mechanisms of regulation, biological effects and molecular targets, and its role in lung diseases caused by inflammatory stimuli, bacteria and virus, and molecularbased therapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51050/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdfMarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdfapplication/pdf1439702https://www.arca.fiocruz.br/bitstream/icict/51050/2/MarciaCarvalho_AdrianaSilva_etal_IOC_2021.pdf6dbad8e4b09b68142ca968a36b393be8MD52icict/510502022-02-07 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dc.title.pt_BR.fl_str_mv |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
title |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
spellingShingle |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases Carvalho, Márcia V. de Lesão pulmonar Desconforto respiratório agudo Inflamação Alvos moleculares PPARY Lung injury Acute respiratory distress Inflammation PPARY Molecular targets |
title_short |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
title_full |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
title_fullStr |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
title_full_unstemmed |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
title_sort |
PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases |
author |
Carvalho, Márcia V. de |
author_facet |
Carvalho, Márcia V. de Albuquerque, Cassiano F. Gonçalves de Silva, Adriana R. |
author_role |
author |
author2 |
Albuquerque, Cassiano F. Gonçalves de Silva, Adriana R. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carvalho, Márcia V. de Albuquerque, Cassiano F. Gonçalves de Silva, Adriana R. |
dc.subject.other.pt_BR.fl_str_mv |
Lesão pulmonar Desconforto respiratório agudo Inflamação Alvos moleculares PPARY |
topic |
Lesão pulmonar Desconforto respiratório agudo Inflamação Alvos moleculares PPARY Lung injury Acute respiratory distress Inflammation PPARY Molecular targets |
dc.subject.en.pt_BR.fl_str_mv |
Lung injury Acute respiratory distress Inflammation PPARY Molecular targets |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-02-07T14:38:34Z |
dc.date.available.fl_str_mv |
2022-02-07T14:38:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/51050 |
dc.identifier.issn.pt_BR.fl_str_mv |
1661-6596 |
dc.identifier.doi.none.fl_str_mv |
10.3390/ijms22020805 |
dc.identifier.eissn.none.fl_str_mv |
1422-0067 |
identifier_str_mv |
CARVALHO, Márcia V.; ALBUQUERQUE, Cassiano F. Gonçalves de; SILVA, Adriana R. PPAR Gamma: From Definition to Molecular Targets and Therapy of Lung Diseases. International Journal of Molecular Sciences, v. 22, n. 805, p. 1 - 20, Jan. 2021. 1661-6596 10.3390/ijms22020805 1422-0067 |
url |
https://www.arca.fiocruz.br/handle/icict/51050 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
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repositorio.arca@fiocruz.br |
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