Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1799 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil |
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Grimaldi, RogérioAcosta, Angelina XavierMachado, Taisa Manuela BonfimBomfim, Thais FerreiraCastro Filho, Bernardo Galvão2011-03-29T20:48:16Z2011-03-29T20:48:16Z2010GRIMALDI, R. et al. Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil. Brazilian Journal of Infectious Diseases, v. 14, n. 2, 197-200, 2010.20563451https://www.arca.fiocruz.br/handle/icict/1799engDistribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia, Faculdade de Medicina. Department of Pediatrics. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilA mutation described as a G-to-A transition has been reported in SDF-1 gene (SDF1-3'A), being prevalent in all ethnic groups, except in Africans. This mutation is associated with the onset of AIDS progression. Our aim was to identify the frequency of this allele in different groups from Brazil: Tiriyó and Waiampi Amerindian tribes (Asian ancestry); selected blood donors from Joinville (German descendents); and from Salvador (predominance of African and Portuguese mixture). SDF1-3'A was screened by PCR/RFLP with MspI enzyme. Our results showed a high allelic frequency in Tiriyó tribe (0.24) and Joinville population (0.21), and a frequency of 0.17 and 0.05 in the Salvador population and in the Waiampi tribe, respectively. There was no statistical difference among the allelic frequencies in the studied ethnic groups, except in the Waiampi. Due to the great genetic diversity among Brazilian population and the lack of studies on SDF1-3'A allele, our study of this allelic frequency in these different Brazilian ethnic groups could be important to identification of biomarker for therapeutic support in progression to AIDS and a molecular marker for analysis of evolutionary relationships among human populations.Infecções por HIV/GEPolimorfismo genéticoMutação/GEQuimiocina CXCL12info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1799/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALDistribution of SDF1-3'A.pdfDistribution of SDF1-3'A.pdfapplication/pdf733112https://www.arca.fiocruz.br/bitstream/icict/1799/2/Distribution%20of%20SDF1-3%27A.pdf52b7800ffff58770c219e97018e8e887MD52TEXTDistribution of SDF1-3'A.pdf.txtDistribution of SDF1-3'A.pdf.txtExtracted texttext/plain21773https://www.arca.fiocruz.br/bitstream/icict/1799/5/Distribution%20of%20SDF1-3%27A.pdf.txt6e536d01acbaf1cd927eeb4fe1cd6738MD55THUMBNAILDistribution of SDF1-3'A.pdf.jpgDistribution of SDF1-3'A.pdf.jpgGenerated Thumbnailimage/jpeg2160https://www.arca.fiocruz.br/bitstream/icict/1799/4/Distribution%20of%20SDF1-3%27A.pdf.jpg8c7f1973e40c691ff3fb571a34fb0a9bMD54icict/17992023-03-15 14:33:12.77oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| title |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| spellingShingle |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil Grimaldi, Rogério Infecções por HIV/GE Polimorfismo genético Mutação/GE Quimiocina CXCL12 |
| title_short |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| title_full |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| title_fullStr |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| title_full_unstemmed |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| title_sort |
Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil |
| author |
Grimaldi, Rogério |
| author_facet |
Grimaldi, Rogério Acosta, Angelina Xavier Machado, Taisa Manuela Bonfim Bomfim, Thais Ferreira Castro Filho, Bernardo Galvão |
| author_role |
author |
| author2 |
Acosta, Angelina Xavier Machado, Taisa Manuela Bonfim Bomfim, Thais Ferreira Castro Filho, Bernardo Galvão |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Grimaldi, Rogério Acosta, Angelina Xavier Machado, Taisa Manuela Bonfim Bomfim, Thais Ferreira Castro Filho, Bernardo Galvão |
| dc.subject.decs.pt_BR.fl_str_mv |
Infecções por HIV/GE Polimorfismo genético Mutação/GE Quimiocina CXCL12 |
| topic |
Infecções por HIV/GE Polimorfismo genético Mutação/GE Quimiocina CXCL12 |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil |
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2010 |
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2010 |
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2011-03-29T20:48:16Z |
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2011-03-29T20:48:16Z |
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GRIMALDI, R. et al. Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil. Brazilian Journal of Infectious Diseases, v. 14, n. 2, 197-200, 2010. |
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GRIMALDI, R. et al. Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil. Brazilian Journal of Infectious Diseases, v. 14, n. 2, 197-200, 2010. 20563451 |
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