Distribution of the CCR2-64I allele in three Brazilian ethnic groups

Detalhes bibliográficos
Autor(a) principal: Acosta, Angelina Xavier
Data de Publicação: 2003
Outros Autores: Sampaio, Rogério Grimaldi, Spínola, Juliana Lima, Castro Filho, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6230
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil
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spelling Acosta, Angelina XavierSampaio, Rogério GrimaldiSpínola, Juliana LimaCastro Filho, Bernardo Galvão2013-01-22T19:14:01Z2013-01-22T19:14:01Z2003ACOSTA, A. X. et al. Distribution of the CCR2-64I allele in three Brazilian ethnic groups. Genetics and Molecular Biology, v. 26, n. 3, p. 241-243, 2003.1415-4757https://www.arca.fiocruz.br/handle/icict/6230engDistribution of the CCR2-64I allele in three Brazilian ethnic groupsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Fundação para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilCCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó tribe); 89 German descendents from Joinville, a city in southern Brazil; and 305 individuals of predominantly African ancestry, from Salvador, a city in northeast Brazil. The CCR2-64I mutant allele was identified in 26% of the Tiryió and 30% of Waiampi samples, in 18% of the Joinville samples, and in 14% of the Salvador samples.CCR2-64I mutationBrazilian populationsHIV co-receptorReceptores CCR5AlelosGenética PopulacionalReceptores de QuimiocinasBrasil/etnologiaInfecções por HIVMutaçãoPolimorfismo GenéticoHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAcosta, Angelina Xavier. et al. Distribution of the....pdfAcosta, Angelina Xavier. et al. 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dc.title.pt_BR.fl_str_mv Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title Distribution of the CCR2-64I allele in three Brazilian ethnic groups
spellingShingle Distribution of the CCR2-64I allele in three Brazilian ethnic groups
Acosta, Angelina Xavier
CCR2-64I mutation
Brazilian populations
HIV co-receptor
Receptores CCR5
Alelos
Genética Populacional
Receptores de Quimiocinas
Brasil/etnologia
Infecções por HIV
Mutação
Polimorfismo Genético
Humanos
title_short Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_full Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_fullStr Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_full_unstemmed Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_sort Distribution of the CCR2-64I allele in three Brazilian ethnic groups
author Acosta, Angelina Xavier
author_facet Acosta, Angelina Xavier
Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro Filho, Bernardo Galvão
author_role author
author2 Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro Filho, Bernardo Galvão
author2_role author
author
author
dc.contributor.author.fl_str_mv Acosta, Angelina Xavier
Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro Filho, Bernardo Galvão
dc.subject.en.pt_BR.fl_str_mv CCR2-64I mutation
Brazilian populations
HIV co-receptor
topic CCR2-64I mutation
Brazilian populations
HIV co-receptor
Receptores CCR5
Alelos
Genética Populacional
Receptores de Quimiocinas
Brasil/etnologia
Infecções por HIV
Mutação
Polimorfismo Genético
Humanos
dc.subject.decs.pt_BR.fl_str_mv Receptores CCR5
Alelos
Genética Populacional
Receptores de Quimiocinas
Brasil/etnologia
Infecções por HIV
Mutação
Polimorfismo Genético
Humanos
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, BA, Brasil
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2013-01-22T19:14:01Z
dc.date.available.fl_str_mv 2013-01-22T19:14:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ACOSTA, A. X. et al. Distribution of the CCR2-64I allele in three Brazilian ethnic groups. Genetics and Molecular Biology, v. 26, n. 3, p. 241-243, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6230
dc.identifier.issn.none.fl_str_mv 1415-4757
identifier_str_mv ACOSTA, A. X. et al. Distribution of the CCR2-64I allele in three Brazilian ethnic groups. Genetics and Molecular Biology, v. 26, n. 3, p. 241-243, 2003.
1415-4757
url https://www.arca.fiocruz.br/handle/icict/6230
dc.language.iso.fl_str_mv eng
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