Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy

Detalhes bibliográficos
Autor(a) principal: Lacerda, Leandra Linhares
Data de Publicação: 2015
Outros Autores: Palu, Cintia Cristina, Alves, Marcelo Ribeiro, Paredes, Bruno Diaz, Morrot, Alexandre, Silva, Maria Rosa Garcia, Cayota, Alfonso, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14818
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
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spelling Lacerda, Leandra LinharesPalu, Cintia CristinaAlves, Marcelo RibeiroParedes, Bruno DiazMorrot, AlexandreSilva, Maria Rosa GarciaCayota, AlfonsoSavino, Wilson2016-07-07T14:43:55Z2016-07-08T18:49:13Z2016-07-07T14:43:55Z2016-07-08T18:49:13Z2015LACERDA, Leandra Linhares et al. Differential Expression of microRNAs in Thymic Epithelial Cells from Trypanosoma cruzi Acutely Infected Mice: Putative Role in Thymic Atrophy. Frontiers Immunology, v. 6, p. 1-12, Aug. 2015.1664-3224https://www.arca.fiocruz.br/handle/icict/1481810.3389/fimmu.2015.00428engFrontiers MediaTimoDoença de ChagasCélulas epiteliais tímicasMigração de TimócitosMicroRNAChagas diseaseThymus atrophyThymic epithelial cellMicroRNAThymocyte migrationDifferential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas (INI). Centro de Pesquisa Clínica em HIV/AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ,Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Institut Pasteur de Montevideo. Functional Genomics Unit. Montevideo, Uruguay.Institut Pasteur de Montevideo. Functional Genomics Unit. Montevideo, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.A common feature seen in acute infections is a severe atrophy of the thymus. This occurs in the murine model of acute Chagas disease. Moreover, in thymuses from Trypanosoma cruzi acutely infected mice, thymocytes exhibit an increase in the density of fibronectin and laminin integrin-type receptors, with an increase in migratory response ex vivo. Thymic epithelial cells (TEC) play a major role in the intrathymic T cell differentiation. To date, the consequences of molecular changes promoted by parasite infection upon thymus have not been elucidated. Considering the importance of microRNA for gene expression regulation, 85 microRNAs (mRNAs) were analyzed in TEC from T. cruzi acutely infected mice. The infection significantly modulated 29 miRNAs and modulation of 9 was also dependent whether TEC sorted out from the thymus exhibited cortical or medullary phenotype. In silico analysis revealed that these miRNAs may control target mRNAs known to be responsible for chemotaxis, cell adhesion, and cell death. Considering that we sorted TEC in the initial phase of thymocyte loss, it is conceivable that changes in TEC miRNA expression profile are functionally related to thymic atrophy, providing new clues to better understanding the mechanisms of the thymic involution seen in experimental Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTleandra_lacerda_etal_IOC_2015.pdf.txtleandra_lacerda_etal_IOC_2015.pdf.txtExtracted texttext/plain58154https://www.arca.fiocruz.br/bitstream/icict/14818/4/leandra_lacerda_etal_IOC_2015.pdf.txt6495679400b3a9af224f3809fb103578MD54ORIGINALleandra_lacerda_etal_IOC_2015.pdfapplication/pdf11457858https://www.arca.fiocruz.br/bitstream/icict/14818/2/leandra_lacerda_etal_IOC_2015.pdf6a886f2491cf01805218e5da9f71f9aaMD52table 1.xlsxtable 1.xlsxMaterial 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dc.title.pt_BR.fl_str_mv Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
title Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
spellingShingle Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
Lacerda, Leandra Linhares
Timo
Doença de Chagas
Células epiteliais tímicas
Migração de Timócitos
MicroRNA
Chagas disease
Thymus atrophy
Thymic epithelial cell
MicroRNA
Thymocyte migration
title_short Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
title_full Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
title_fullStr Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
title_full_unstemmed Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
title_sort Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy
author Lacerda, Leandra Linhares
author_facet Lacerda, Leandra Linhares
Palu, Cintia Cristina
Alves, Marcelo Ribeiro
Paredes, Bruno Diaz
Morrot, Alexandre
Silva, Maria Rosa Garcia
Cayota, Alfonso
Savino, Wilson
author_role author
author2 Palu, Cintia Cristina
Alves, Marcelo Ribeiro
Paredes, Bruno Diaz
Morrot, Alexandre
Silva, Maria Rosa Garcia
Cayota, Alfonso
Savino, Wilson
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lacerda, Leandra Linhares
Palu, Cintia Cristina
Alves, Marcelo Ribeiro
Paredes, Bruno Diaz
Morrot, Alexandre
Silva, Maria Rosa Garcia
Cayota, Alfonso
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Timo
Doença de Chagas
Células epiteliais tímicas
Migração de Timócitos
MicroRNA
topic Timo
Doença de Chagas
Células epiteliais tímicas
Migração de Timócitos
MicroRNA
Chagas disease
Thymus atrophy
Thymic epithelial cell
MicroRNA
Thymocyte migration
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Thymus atrophy
Thymic epithelial cell
MicroRNA
Thymocyte migration
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-07-07T14:43:55Z
2016-07-08T18:49:13Z
dc.date.available.fl_str_mv 2016-07-07T14:43:55Z
2016-07-08T18:49:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv LACERDA, Leandra Linhares et al. Differential Expression of microRNAs in Thymic Epithelial Cells from Trypanosoma cruzi Acutely Infected Mice: Putative Role in Thymic Atrophy. Frontiers Immunology, v. 6, p. 1-12, Aug. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14818
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fimmu.2015.00428
identifier_str_mv LACERDA, Leandra Linhares et al. Differential Expression of microRNAs in Thymic Epithelial Cells from Trypanosoma cruzi Acutely Infected Mice: Putative Role in Thymic Atrophy. Frontiers Immunology, v. 6, p. 1-12, Aug. 2015.
1664-3224
10.3389/fimmu.2015.00428
url https://www.arca.fiocruz.br/handle/icict/14818
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dc.publisher.none.fl_str_mv Frontiers Media
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