Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/0074-02760220109 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56641 |
Resumo: | Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. |
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Silva, Gabriela Porto Santos AlmeidaOliveira, Rodrigo CunhaSouza, Juliana Sacramento Mota deGiovanetti, MartaGuimarães, Monick LindenmeyerBrites, CarlosCunha, Joana Paixão Monteiro2023-01-26T17:29:09Z2023-01-26T17:29:09Z2022SILVA, Gabriela Porto Santos Almeida et al. Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220109, p. 1 - 7, 2022.0074-0206https://www.arca.fiocruz.br/handle/icict/5664110.1590/0074-02760220109engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.HIVF1 sub-subtipoFilodinâmicaRecombinantesBF1HIVF1 sub-subtypePhylodynamicRecombinantsBF1Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspectiveinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil.Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil.Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz . Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil.Europe, and South America. In Brazil, this sub-subtype co-circulates with subtypes B and C and several recombinant forms, mainly BF1 variants. OBJECTIVES This study aimed to reconstruct the dynamic history of HIV-1 F1 in Brazil. METHODS HIV-1 near full-length genome and pol gene nucleotide sequences available in public databases were assembled in two datasets (POL671 and NFLG53) to cover the largest number of F1 sub-subtype sequences. Phylodynamic and temporal analyses were performed. FINDINGS Two main strains of the F1 sub-subtype are circulating worldwide. The first (F1.I) was found among Brazilian samples (75%) and the second (F1.II) among Romanian (62%) and other European and African isolates. The F1 subtype epidemic in Brazil originated from a single entry into the country around 1970. This ancestral sample is related to samples isolated in European countries (France, Finland, and Belgium), which are possibly of African origin. Moreover, further migration (1998 CI: 1994-2003) of strains from Brazil to Europe (Spain and the UK) was observed. Interestingly, all different recombinant BF patterns found, even those from outside Brazil, present the same F1 lineage (F1.I) as an ancestor, which could be related to the acquisition of adaptive advantages for the recombinant progenies. MAIN CONCLUSIONS These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56641/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMoniqueGuimaraes_GabrielaSilva_etal_IOC_2022.pdfMoniqueGuimaraes_GabrielaSilva_etal_IOC_2022.pdfapplication/pdf769300https://www.arca.fiocruz.br/bitstream/icict/56641/2/MoniqueGuimaraes_GabrielaSilva_etal_IOC_2022.pdf4366ed59c046ed97fdab1bc0e96e7d93MD52icict/566412023-09-04 11:10:54.04oai:www.arca.fiocruz.br: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ório 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| dc.title.en_US.fl_str_mv |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| title |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| spellingShingle |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective Silva, Gabriela Porto Santos Almeida HIV F1 sub-subtipo Filodinâmica Recombinantes BF1 HIV F1 sub-subtype Phylodynamic Recombinants BF1 |
| title_short |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| title_full |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| title_fullStr |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| title_full_unstemmed |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| title_sort |
Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective |
| author |
Silva, Gabriela Porto Santos Almeida |
| author_facet |
Silva, Gabriela Porto Santos Almeida Oliveira, Rodrigo Cunha Souza, Juliana Sacramento Mota de Giovanetti, Marta Guimarães, Monick Lindenmeyer Brites, Carlos Cunha, Joana Paixão Monteiro |
| author_role |
author |
| author2 |
Oliveira, Rodrigo Cunha Souza, Juliana Sacramento Mota de Giovanetti, Marta Guimarães, Monick Lindenmeyer Brites, Carlos Cunha, Joana Paixão Monteiro |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Gabriela Porto Santos Almeida Oliveira, Rodrigo Cunha Souza, Juliana Sacramento Mota de Giovanetti, Marta Guimarães, Monick Lindenmeyer Brites, Carlos Cunha, Joana Paixão Monteiro |
| dc.subject.other.en_US.fl_str_mv |
HIV F1 sub-subtipo Filodinâmica Recombinantes BF1 |
| topic |
HIV F1 sub-subtipo Filodinâmica Recombinantes BF1 HIV F1 sub-subtype Phylodynamic Recombinants BF1 |
| dc.subject.en.en_US.fl_str_mv |
HIV F1 sub-subtype Phylodynamic Recombinants BF1 |
| description |
Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. |
| publishDate |
2022 |
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2022 |
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2023-01-26T17:29:09Z |
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2023-01-26T17:29:09Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVA, Gabriela Porto Santos Almeida et al. Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220109, p. 1 - 7, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56641 |
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0074-0206 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760220109 |
| identifier_str_mv |
SILVA, Gabriela Porto Santos Almeida et al. Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220109, p. 1 - 7, 2022. 0074-0206 10.1590/0074-02760220109 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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