Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil

Detalhes bibliográficos
Autor(a) principal: Alcalde, Rosana
Data de Publicação: 2012
Outros Autores: Guimarães, Monick L., Duarte, Alberto J. S., Casseb, Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15802
Resumo: Universidade de São Paulo. Escola de Medicina. Departamento de Dermatologia. Laboratório de Dermatologia e Imunodeficiências. São Paulo, SP, Brasil.
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spelling Alcalde, RosanaGuimarães, Monick L.Duarte, Alberto J. S.Casseb, Jorge2016-09-15T11:54:39Z2016-09-15T11:54:39Z2012ALCALDE, Rosana; et al. Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil. Virology Journal, v.9:156, 10p, 2012.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/1580210.1186/1743-422X-9-156engBioMed CentralHIV-1SubtiposRecombinantesResistênciaSão PauloBrasilHIV-1SubtypesRecombinantsResistanceSão PauloBrazilClinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina. Departamento de Dermatologia. Laboratório de Dermatologia e Imunodeficiências. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina. Departamento de Dermatologia. Laboratório de Dermatologia e Imunodeficiências. São Paulo, SP, Brasil.Universidade de São Paulo. Escola de Medicina. Departamento de Dermatologia. Laboratório de Dermatologia e Imunodeficiências. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil.Background: The city of Sao Paulo has the highest AIDS case rate, with nearly 60% in Brazil. Despite, several studies involving molecular epidemiology, lack of data regarding a large cohort study has not been published from this city. Objectives: This study aimed to describe the HIV-1 subtypes, recombinant forms and drug resistance mutations, according to subtype, with emphasis on subtype C and BC recombinants in the city of São Paulo, Brazil. Study design: RNA was extracted from the plasma samples of 302 HIV-1-seropositive subjects, of which 211 were drug-naive and 82 were exposed to ART. HIV-1 partial pol region sequences were used in phylogenetic analyses for subtyping and identification of drug resistance mutations. The envelope gene of subtype C and BC samples was also sequenced. Results: From partial pol gene analyses, 239 samples (79.1%) were assigned as subtype B, 23 (7.6%) were F1, 16 (5.3%) were subtype C and 24 (8%) were mosaics (3 CRF28/CRF29-like). The subtype C and BC recombinants were mainly identified in drug-naïve patients (72.7%) and the heterosexual risk exposure category (86.3%), whereas for subtype B, these values were 69.9% and 57.3%, respectively (p = 0.97 and p = 0.015, respectively). An increasing trend of subtype C and BC recombinants was observed (p < 0.01). Conclusion: The HIV-1 subtype C and CRFs seem to have emerged over the last few years in the city of São Paulo, principally among the heterosexual population. These findings may have an impact on preventive measures and vaccine development in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15802/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmonik_guimaraes_etal_IOC_2012.pdfmonik_guimaraes_etal_IOC_2012.pdfapplication/pdf465295https://www.arca.fiocruz.br/bitstream/icict/15802/2/monik_guimaraes_etal_IOC_2012.pdf6b96639252c1c4d336239600e540002aMD52TEXTmonik_guimaraes_etal_IOC_2012.pdf.txtmonik_guimaraes_etal_IOC_2012.pdf.txtExtracted texttext/plain40903https://www.arca.fiocruz.br/bitstream/icict/15802/3/monik_guimaraes_etal_IOC_2012.pdf.txtaf57324414bde5e84574189358cacb5cMD53icict/158022018-04-02 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dc.title.pt_BR.fl_str_mv Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
title Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
spellingShingle Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
Alcalde, Rosana
HIV-1
Subtipos
Recombinantes
Resistência
São Paulo
Brasil
HIV-1
Subtypes
Recombinants
Resistance
São Paulo
Brazil
title_short Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
title_full Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
title_fullStr Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
title_full_unstemmed Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
title_sort Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil
author Alcalde, Rosana
author_facet Alcalde, Rosana
Guimarães, Monick L.
Duarte, Alberto J. S.
Casseb, Jorge
author_role author
author2 Guimarães, Monick L.
Duarte, Alberto J. S.
Casseb, Jorge
author2_role author
author
author
dc.contributor.author.fl_str_mv Alcalde, Rosana
Guimarães, Monick L.
Duarte, Alberto J. S.
Casseb, Jorge
dc.subject.other.pt_BR.fl_str_mv HIV-1
Subtipos
Recombinantes
Resistência
São Paulo
Brasil
topic HIV-1
Subtipos
Recombinantes
Resistência
São Paulo
Brasil
HIV-1
Subtypes
Recombinants
Resistance
São Paulo
Brazil
dc.subject.en.pt_BR.fl_str_mv HIV-1
Subtypes
Recombinants
Resistance
São Paulo
Brazil
description Universidade de São Paulo. Escola de Medicina. Departamento de Dermatologia. Laboratório de Dermatologia e Imunodeficiências. São Paulo, SP, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-09-15T11:54:39Z
dc.date.available.fl_str_mv 2016-09-15T11:54:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALCALDE, Rosana; et al. Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil. Virology Journal, v.9:156, 10p, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15802
dc.identifier.issn.pt_BR.fl_str_mv 1743-422X
dc.identifier.doi.none.fl_str_mv 10.1186/1743-422X-9-156
identifier_str_mv ALCALDE, Rosana; et al. Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil. Virology Journal, v.9:156, 10p, 2012.
1743-422X
10.1186/1743-422X-9-156
url https://www.arca.fiocruz.br/handle/icict/15802
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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