Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients

Detalhes bibliográficos
Autor(a) principal: Costa, Ronaldo P
Data de Publicação: 2003
Outros Autores: Gollob, Kenneth J, Machado, Paulo Roberto, Bacellar, Maria Olívia Amado Ramos, Almeida, Roque Pacheco de, Barral, Aldina Maria Prado, Barral Netto, Manoel, Carvalho Filho, Edgar Marcelino, Dutra, Walderez Ornelas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7436
Resumo: Universidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, Brasil
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spelling Costa, Ronaldo PGollob, Kenneth JMachado, Paulo RobertoBacellar, Maria Olívia Amado RamosAlmeida, Roque Pacheco deBarral, Aldina Maria PradoBarral Netto, ManoelCarvalho Filho, Edgar MarcelinoDutra, Walderez Ornelas2014-03-21T18:59:46Z2014-03-21T18:59:46Z2003COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003.0165-247810.1016/j.imlet.2003.09.001https://www.arca.fiocruz.br/handle/icict/7436engElsevier B.VAdhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gearis. ICB. Laboratory of Lymphocyte Biology. Department of Biochemistry-Immunolog. Belo Horizonte, Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, BrasilAdhesion molecules play a crucial role in cell migration and recruitment. Expression of adhesion molecules that preferentially address cells to inflammatory sites is a critical event in the formation and maintenance of leishmaniasis lesions. In this work, we analyzed the expression of CD11a, CD11b and CD62L, adhesion molecules involved in cell activation and circulation, in CD4+ and CD8+ T cells from peripheral blood and lymph nodes of patients with early cutaneous leishmaniasis. The percentage of expression of CD62L, CD11a and CD11b in total lymphocytes was lower in lymph nodes as compared to peripheral blood. Moreover, differences in adhesion molecule expression between blood and lymph nodes were more striking in CD4+ than CD8+ T cells. Stimulation of PBMC from leishmaniasis patients with soluble Leishmania antigens (SLA) lead to the expansion of CD4+CD62Lhigh cells, CD4+CD11b+ cells and to an increase in the intensity of expression of CD11a in CD4+, but not CD8+ T cells. Our data suggest that early activation events that occur in the lymph nodes of patients recently infected with Leishmania lead to changes in T cell adhesion molecule expression, favoring migration to the periphery and increasing the likelihood of further recruitment to lesion sites.LeishmaniasisAdhesion moleculesLymph nodeLymphocytesPeripheral bloodLinfócitos T CD4-Positivos/imunologiaMoléculas de Adesão Celular/metabolismoLeishmaniose Cutânea/sangueLeishmaniose Cutânea/imunologiaLinfonodos/imunologiaAtivação LinfocitáriaAnimaisAntígenos CD/análiseAntígenos CD/imunologiaAntígenos de Protozoários/imunologiaLinfócitos T CD8-Positivos/imunologiaHumanosImunofenotipagemLeishmania/imunologiaLinfonodos/citologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCosta R P Adhesion molecule expression....pdfCosta R P Adhesion molecule expression....pdfapplication/pdf80657https://www.arca.fiocruz.br/bitstream/icict/7436/1/Costa%20R%20P%20Adhesion%20molecule%20expression....pdfb9396ff55bf040820da81dd1bb476ff5MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7436/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCosta R P Adhesion molecule expression....pdf.txtCosta R P Adhesion molecule expression....pdf.txtExtracted texttext/plain23051https://www.arca.fiocruz.br/bitstream/icict/7436/5/Costa%20R%20P%20Adhesion%20molecule%20expression....pdf.txt16c5cb5c2704256148efad1d357cdb3fMD55THUMBNAILCosta R P Adhesion molecule expression....pdf.jpgCosta R P Adhesion molecule expression....pdf.jpgGenerated Thumbnailimage/jpeg1469https://www.arca.fiocruz.br/bitstream/icict/7436/4/Costa%20R%20P%20Adhesion%20molecule%20expression....pdf.jpg5bcb8956d943ea84a304f3bde3f9625dMD54icict/74362023-03-15 14:33:09.84oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
title Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
spellingShingle Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
Costa, Ronaldo P
Leishmaniasis
Adhesion molecules
Lymph node
Lymphocytes
Peripheral blood
Linfócitos T CD4-Positivos/imunologia
Moléculas de Adesão Celular/metabolismo
Leishmaniose Cutânea/sangue
Leishmaniose Cutânea/imunologia
Linfonodos/imunologia
Ativação Linfocitária
Animais
Antígenos CD/análise
Antígenos CD/imunologia
Antígenos de Protozoários/imunologia
Linfócitos T CD8-Positivos/imunologia
Humanos
Imunofenotipagem
Leishmania/imunologia
Linfonodos/citologia
title_short Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
title_full Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
title_fullStr Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
title_full_unstemmed Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
title_sort Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
author Costa, Ronaldo P
author_facet Costa, Ronaldo P
Gollob, Kenneth J
Machado, Paulo Roberto
Bacellar, Maria Olívia Amado Ramos
Almeida, Roque Pacheco de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Carvalho Filho, Edgar Marcelino
Dutra, Walderez Ornelas
author_role author
author2 Gollob, Kenneth J
Machado, Paulo Roberto
Bacellar, Maria Olívia Amado Ramos
Almeida, Roque Pacheco de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Carvalho Filho, Edgar Marcelino
Dutra, Walderez Ornelas
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Ronaldo P
Gollob, Kenneth J
Machado, Paulo Roberto
Bacellar, Maria Olívia Amado Ramos
Almeida, Roque Pacheco de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Carvalho Filho, Edgar Marcelino
Dutra, Walderez Ornelas
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Adhesion molecules
Lymph node
Lymphocytes
Peripheral blood
topic Leishmaniasis
Adhesion molecules
Lymph node
Lymphocytes
Peripheral blood
Linfócitos T CD4-Positivos/imunologia
Moléculas de Adesão Celular/metabolismo
Leishmaniose Cutânea/sangue
Leishmaniose Cutânea/imunologia
Linfonodos/imunologia
Ativação Linfocitária
Animais
Antígenos CD/análise
Antígenos CD/imunologia
Antígenos de Protozoários/imunologia
Linfócitos T CD8-Positivos/imunologia
Humanos
Imunofenotipagem
Leishmania/imunologia
Linfonodos/citologia
dc.subject.decs.pt_BR.fl_str_mv Linfócitos T CD4-Positivos/imunologia
Moléculas de Adesão Celular/metabolismo
Leishmaniose Cutânea/sangue
Leishmaniose Cutânea/imunologia
Linfonodos/imunologia
Ativação Linfocitária
Animais
Antígenos CD/análise
Antígenos CD/imunologia
Antígenos de Protozoários/imunologia
Linfócitos T CD8-Positivos/imunologia
Humanos
Imunofenotipagem
Leishmania/imunologia
Linfonodos/citologia
description Universidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, Brasil
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-03-21T18:59:46Z
dc.date.available.fl_str_mv 2014-03-21T18:59:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7436
dc.identifier.issn.none.fl_str_mv 0165-2478
10.1016/j.imlet.2003.09.001
identifier_str_mv COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003.
0165-2478
10.1016/j.imlet.2003.09.001
url https://www.arca.fiocruz.br/handle/icict/7436
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier B.V
publisher.none.fl_str_mv Elsevier B.V
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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