Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7436 |
Resumo: | Universidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, Brasil |
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Costa, Ronaldo PGollob, Kenneth JMachado, Paulo RobertoBacellar, Maria Olívia Amado RamosAlmeida, Roque Pacheco deBarral, Aldina Maria PradoBarral Netto, ManoelCarvalho Filho, Edgar MarcelinoDutra, Walderez Ornelas2014-03-21T18:59:46Z2014-03-21T18:59:46Z2003COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003.0165-247810.1016/j.imlet.2003.09.001https://www.arca.fiocruz.br/handle/icict/7436engElsevier B.VAdhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gearis. ICB. Laboratory of Lymphocyte Biology. Department of Biochemistry-Immunolog. Belo Horizonte, Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, BrasilAdhesion molecules play a crucial role in cell migration and recruitment. Expression of adhesion molecules that preferentially address cells to inflammatory sites is a critical event in the formation and maintenance of leishmaniasis lesions. In this work, we analyzed the expression of CD11a, CD11b and CD62L, adhesion molecules involved in cell activation and circulation, in CD4+ and CD8+ T cells from peripheral blood and lymph nodes of patients with early cutaneous leishmaniasis. The percentage of expression of CD62L, CD11a and CD11b in total lymphocytes was lower in lymph nodes as compared to peripheral blood. Moreover, differences in adhesion molecule expression between blood and lymph nodes were more striking in CD4+ than CD8+ T cells. Stimulation of PBMC from leishmaniasis patients with soluble Leishmania antigens (SLA) lead to the expansion of CD4+CD62Lhigh cells, CD4+CD11b+ cells and to an increase in the intensity of expression of CD11a in CD4+, but not CD8+ T cells. Our data suggest that early activation events that occur in the lymph nodes of patients recently infected with Leishmania lead to changes in T cell adhesion molecule expression, favoring migration to the periphery and increasing the likelihood of further recruitment to lesion sites.LeishmaniasisAdhesion moleculesLymph nodeLymphocytesPeripheral bloodLinfócitos T CD4-Positivos/imunologiaMoléculas de Adesão Celular/metabolismoLeishmaniose Cutânea/sangueLeishmaniose Cutânea/imunologiaLinfonodos/imunologiaAtivação LinfocitáriaAnimaisAntígenos CD/análiseAntígenos CD/imunologiaAntígenos de Protozoários/imunologiaLinfócitos T CD8-Positivos/imunologiaHumanosImunofenotipagemLeishmania/imunologiaLinfonodos/citologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCosta R P Adhesion molecule expression....pdfCosta R P Adhesion molecule expression....pdfapplication/pdf80657https://www.arca.fiocruz.br/bitstream/icict/7436/1/Costa%20R%20P%20Adhesion%20molecule%20expression....pdfb9396ff55bf040820da81dd1bb476ff5MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7436/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCosta R P Adhesion molecule expression....pdf.txtCosta R P Adhesion molecule expression....pdf.txtExtracted texttext/plain23051https://www.arca.fiocruz.br/bitstream/icict/7436/5/Costa%20R%20P%20Adhesion%20molecule%20expression....pdf.txt16c5cb5c2704256148efad1d357cdb3fMD55THUMBNAILCosta R P Adhesion molecule expression....pdf.jpgCosta R P Adhesion molecule expression....pdf.jpgGenerated Thumbnailimage/jpeg1469https://www.arca.fiocruz.br/bitstream/icict/7436/4/Costa%20R%20P%20Adhesion%20molecule%20expression....pdf.jpg5bcb8956d943ea84a304f3bde3f9625dMD54icict/74362023-03-15 14:33:09.84oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
title |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
spellingShingle |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients Costa, Ronaldo P Leishmaniasis Adhesion molecules Lymph node Lymphocytes Peripheral blood Linfócitos T CD4-Positivos/imunologia Moléculas de Adesão Celular/metabolismo Leishmaniose Cutânea/sangue Leishmaniose Cutânea/imunologia Linfonodos/imunologia Ativação Linfocitária Animais Antígenos CD/análise Antígenos CD/imunologia Antígenos de Protozoários/imunologia Linfócitos T CD8-Positivos/imunologia Humanos Imunofenotipagem Leishmania/imunologia Linfonodos/citologia |
title_short |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
title_full |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
title_fullStr |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
title_full_unstemmed |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
title_sort |
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients |
author |
Costa, Ronaldo P |
author_facet |
Costa, Ronaldo P Gollob, Kenneth J Machado, Paulo Roberto Bacellar, Maria Olívia Amado Ramos Almeida, Roque Pacheco de Barral, Aldina Maria Prado Barral Netto, Manoel Carvalho Filho, Edgar Marcelino Dutra, Walderez Ornelas |
author_role |
author |
author2 |
Gollob, Kenneth J Machado, Paulo Roberto Bacellar, Maria Olívia Amado Ramos Almeida, Roque Pacheco de Barral, Aldina Maria Prado Barral Netto, Manoel Carvalho Filho, Edgar Marcelino Dutra, Walderez Ornelas |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Ronaldo P Gollob, Kenneth J Machado, Paulo Roberto Bacellar, Maria Olívia Amado Ramos Almeida, Roque Pacheco de Barral, Aldina Maria Prado Barral Netto, Manoel Carvalho Filho, Edgar Marcelino Dutra, Walderez Ornelas |
dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Adhesion molecules Lymph node Lymphocytes Peripheral blood |
topic |
Leishmaniasis Adhesion molecules Lymph node Lymphocytes Peripheral blood Linfócitos T CD4-Positivos/imunologia Moléculas de Adesão Celular/metabolismo Leishmaniose Cutânea/sangue Leishmaniose Cutânea/imunologia Linfonodos/imunologia Ativação Linfocitária Animais Antígenos CD/análise Antígenos CD/imunologia Antígenos de Protozoários/imunologia Linfócitos T CD8-Positivos/imunologia Humanos Imunofenotipagem Leishmania/imunologia Linfonodos/citologia |
dc.subject.decs.pt_BR.fl_str_mv |
Linfócitos T CD4-Positivos/imunologia Moléculas de Adesão Celular/metabolismo Leishmaniose Cutânea/sangue Leishmaniose Cutânea/imunologia Linfonodos/imunologia Ativação Linfocitária Animais Antígenos CD/análise Antígenos CD/imunologia Antígenos de Protozoários/imunologia Linfócitos T CD8-Positivos/imunologia Humanos Imunofenotipagem Leishmania/imunologia Linfonodos/citologia |
description |
Universidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, Brasil |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2014-03-21T18:59:46Z |
dc.date.available.fl_str_mv |
2014-03-21T18:59:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7436 |
dc.identifier.issn.none.fl_str_mv |
0165-2478 10.1016/j.imlet.2003.09.001 |
identifier_str_mv |
COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003. 0165-2478 10.1016/j.imlet.2003.09.001 |
url |
https://www.arca.fiocruz.br/handle/icict/7436 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier B.V |
publisher.none.fl_str_mv |
Elsevier B.V |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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