Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review

Detalhes bibliográficos
Autor(a) principal: Japiassú, André M.
Data de Publicação: 2009
Outros Autores: Salluh, Jorge I. F., Bozza, Patrícia T., Bozza, Fernando A., Faria Neto, Hugo C. Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28995
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.
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spelling Japiassú, André M.Salluh, Jorge I. F.Bozza, Patrícia T.Bozza, Fernando A.Faria Neto, Hugo C. Castro2018-09-23T13:41:52Z2018-09-23T13:41:52Z2009JAPIASSÚ, André M. et al. Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 4, p. 531-548, July 2009.0074-0276https://www.arca.fiocruz.br/handle/icict/2899510.1590/S0074-027620090004000011678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.GlicocorticóidesChoque sépticoTerapêuticaInfecções bacterianasSepseSepsisSeptic shockGlucocorticoidsTherapeuticsBacterial infectionsRevisiting steroid treatment for septic shock: molecular actions and clinical effects - a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Corticosteroids are widely used to treat a diversity of pathological conditions including allergic, autoimmune and some infectious diseases. These drugs have complex mechanisms of action involving both genomic and nongenomic mechanisms and interfere with different signal transduction pathways in the cell. The use of corticosteroids to treat critically ill patients with acute respiratory distress syndrome and severe infections, such as sepsis and pneumonia, is still a matter of intense debate in the scientific and medical community with evidence both for and against its use in these patients. Here, we review the basic molecular mechanisms important for corticosteroid action as well as current evidence for their use, or not, in septic patients. We also present an analysis of the reasons why this is still such a controversial point in the literature.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28995/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALandre_japiassu_etal_IOC_2009.pdfandre_japiassu_etal_IOC_2009.pdfapplication/pdf1255262https://www.arca.fiocruz.br/bitstream/icict/28995/2/andre_japiassu_etal_IOC_2009.pdf9939a39e69bbe959809bedabc1ae172aMD52TEXTandre_japiassu_etal_IOC_2009.pdf.txtandre_japiassu_etal_IOC_2009.pdf.txtExtracted texttext/plain108846https://www.arca.fiocruz.br/bitstream/icict/28995/3/andre_japiassu_etal_IOC_2009.pdf.txt9c7605b4c4d493090fe8f3e1e3dcc373MD53icict/289952022-06-24 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dc.title.pt_BR.fl_str_mv Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
spellingShingle Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
Japiassú, André M.
Glicocorticóides
Choque séptico
Terapêutica
Infecções bacterianas
Sepse
Sepsis
Septic shock
Glucocorticoids
Therapeutics
Bacterial infections
title_short Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_full Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_fullStr Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_full_unstemmed Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_sort Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
author Japiassú, André M.
author_facet Japiassú, André M.
Salluh, Jorge I. F.
Bozza, Patrícia T.
Bozza, Fernando A.
Faria Neto, Hugo C. Castro
author_role author
author2 Salluh, Jorge I. F.
Bozza, Patrícia T.
Bozza, Fernando A.
Faria Neto, Hugo C. Castro
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Japiassú, André M.
Salluh, Jorge I. F.
Bozza, Patrícia T.
Bozza, Fernando A.
Faria Neto, Hugo C. Castro
dc.subject.other.pt_BR.fl_str_mv Glicocorticóides
Choque séptico
Terapêutica
Infecções bacterianas
Sepse
topic Glicocorticóides
Choque séptico
Terapêutica
Infecções bacterianas
Sepse
Sepsis
Septic shock
Glucocorticoids
Therapeutics
Bacterial infections
dc.subject.en.pt_BR.fl_str_mv Sepsis
Septic shock
Glucocorticoids
Therapeutics
Bacterial infections
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-09-23T13:41:52Z
dc.date.available.fl_str_mv 2018-09-23T13:41:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv JAPIASSÚ, André M. et al. Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 4, p. 531-548, July 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28995
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762009000400001
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv JAPIASSÚ, André M. et al. Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 4, p. 531-548, July 2009.
0074-0276
10.1590/S0074-02762009000400001
1678-8060
url https://www.arca.fiocruz.br/handle/icict/28995
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/28995/1/license.txt
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