Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review

Detalhes bibliográficos
Autor(a) principal: Japiassú,André M
Data de Publicação: 2009
Outros Autores: Salluh,Jorge IF, Bozza,Patrícia T, Bozza,Fernando A, Castro-Faria-Neto,Hugo C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400001
Resumo: Corticosteroids are widely used to treat a diversity of pathological conditions including allergic, autoimmune and some infectious diseases. These drugs have complex mechanisms of action involving both genomic and non-genomic mechanisms and interfere with different signal transduction pathways in the cell. The use of corticosteroids to treat critically ill patients with acute respiratory distress syndrome and severe infections, such as sepsis and pneumonia, is still a matter of intense debate in the scientific and medical community with evidence both for and against its use in these patients. Here, we review the basic molecular mechanisms important for corticosteroid action as well as current evidence for their use, or not, in septic patients. We also present an analysis of the reasons why this is still such a controversial point in the literature.
id FIOCRUZ-4_4f4b7dd34914b93c7de897961b81ff9d
oai_identifier_str oai:scielo:S0074-02762009000400001
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a reviewsepsisseptic shockglucocorticoidstherapeuticsbacterial infectionsCorticosteroids are widely used to treat a diversity of pathological conditions including allergic, autoimmune and some infectious diseases. These drugs have complex mechanisms of action involving both genomic and non-genomic mechanisms and interfere with different signal transduction pathways in the cell. The use of corticosteroids to treat critically ill patients with acute respiratory distress syndrome and severe infections, such as sepsis and pneumonia, is still a matter of intense debate in the scientific and medical community with evidence both for and against its use in these patients. Here, we review the basic molecular mechanisms important for corticosteroid action as well as current evidence for their use, or not, in septic patients. We also present an analysis of the reasons why this is still such a controversial point in the literature.Instituto Oswaldo Cruz, Ministério da Saúde2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400001Memórias do Instituto Oswaldo Cruz v.104 n.4 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000400001info:eu-repo/semantics/openAccessJapiassú,André MSalluh,Jorge IFBozza,Patrícia TBozza,Fernando ACastro-Faria-Neto,Hugo Ceng2020-04-25T17:50:29Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:13.374Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
spellingShingle Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
Japiassú,André M
sepsis
septic shock
glucocorticoids
therapeutics
bacterial infections
title_short Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_full Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_fullStr Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_full_unstemmed Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
title_sort Revisiting steroid treatment for septic shock: molecular actions and clinical effects - a review
author Japiassú,André M
author_facet Japiassú,André M
Salluh,Jorge IF
Bozza,Patrícia T
Bozza,Fernando A
Castro-Faria-Neto,Hugo C
author_role author
author2 Salluh,Jorge IF
Bozza,Patrícia T
Bozza,Fernando A
Castro-Faria-Neto,Hugo C
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Japiassú,André M
Salluh,Jorge IF
Bozza,Patrícia T
Bozza,Fernando A
Castro-Faria-Neto,Hugo C
dc.subject.por.fl_str_mv sepsis
septic shock
glucocorticoids
therapeutics
bacterial infections
topic sepsis
septic shock
glucocorticoids
therapeutics
bacterial infections
dc.description.none.fl_txt_mv Corticosteroids are widely used to treat a diversity of pathological conditions including allergic, autoimmune and some infectious diseases. These drugs have complex mechanisms of action involving both genomic and non-genomic mechanisms and interfere with different signal transduction pathways in the cell. The use of corticosteroids to treat critically ill patients with acute respiratory distress syndrome and severe infections, such as sepsis and pneumonia, is still a matter of intense debate in the scientific and medical community with evidence both for and against its use in these patients. Here, we review the basic molecular mechanisms important for corticosteroid action as well as current evidence for their use, or not, in septic patients. We also present an analysis of the reasons why this is still such a controversial point in the literature.
description Corticosteroids are widely used to treat a diversity of pathological conditions including allergic, autoimmune and some infectious diseases. These drugs have complex mechanisms of action involving both genomic and non-genomic mechanisms and interfere with different signal transduction pathways in the cell. The use of corticosteroids to treat critically ill patients with acute respiratory distress syndrome and severe infections, such as sepsis and pneumonia, is still a matter of intense debate in the scientific and medical community with evidence both for and against its use in these patients. Here, we review the basic molecular mechanisms important for corticosteroid action as well as current evidence for their use, or not, in septic patients. We also present an analysis of the reasons why this is still such a controversial point in the literature.
publishDate 2009
dc.date.none.fl_str_mv 2009-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400001
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762009000400001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.104 n.4 2009
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937705466724352

Registros relacionados