Considerations about gastric cancer proteomics

Detalhes bibliográficos
Autor(a) principal: Carvalho, Carlos Eduardo
Data de Publicação: 2016
Outros Autores: Mccormick, Thaís Messias, Carvalho, Paulo Costa, Fischer, Juliana de Saldanha da Gama, Aquino, Priscila Ferreira de, Bravo Neto, Guilherme Pinto, Carvalho, Maria da Gloria da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20438
Resumo: A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica.
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spelling Carvalho, Carlos EduardoMccormick, Thaís MessiasCarvalho, Paulo CostaFischer, Juliana de Saldanha da GamaAquino, Priscila Ferreira deBravo Neto, Guilherme PintoCarvalho, Maria da Gloria da Costa2017-07-28T12:59:35Z2017-07-28T12:59:35Z2016CARVALHO, Carlos Eduardo et al. Considerations about gastric cancer proteomics. Revista do Colégio Brasileiro de Cirurgiões, v. 43, n. 5, p. 395-397, 2016.0100-6991https://www.arca.fiocruz.br/handle/icict/2043810.1590/0100-69912016005016A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica.The frequency of molecular studies aimed to analyze promoter methylation of tumor suppressor genes and global proteomics in gastric carcinogenesis is increasing. Nonetheless, only a few considered the different types of stomach cells, the tumor location and the influence of Helicobacter pylori and Epstein Barr virus infection (EBV). Molecular differences relating to anatomical and histological tumor areas were also recently described. The authors propose a molecular classification of gastric cancer, dividing it into four subtypes: tumors positive for EBV; microsatellite unstable tumors; genomically stable tumors and tumors with chromosomal instability.Department of Pathology. Faculty of Medicine. Federal University of Janeiro. Rio de Janeiro, RJ, Brazil.Department of Pathology. Faculty of Medicine. Federal University of Janeiro. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica e Engenharia de Proteínas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica e Engenharia de Proteínas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Amazonas, AM, Brasil.Department of Surgery. Faculty of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Department of Pathology. Faculty of Medicine. Federal University of Janeiro. Rio de Janeiro, RJ, Brazil.engColégio Brasileiro de CirurgiõesHumanoStomach NeoplasmsProteomeHelicobacter pyloriHerpesvirus 4MethylationNeoplasias GástricasProteomaHelicobacter pyloriHerpesvirus 4MetilaciónNeoplasias GástricasProteomaHelicobacter pyloriHerpesvirus 4MetilaçãoConsiderations about gastric cancer proteomicsConsiderações sobre proteômica no câncer gástricoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20438/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALConsiderations about gastric cancer proteomics.pdfConsiderations about gastric cancer 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dc.title.pt_BR.fl_str_mv Considerations about gastric cancer proteomics
dc.title.alternative.pt_BR.fl_str_mv Considerações sobre proteômica no câncer gástrico
title Considerations about gastric cancer proteomics
spellingShingle Considerations about gastric cancer proteomics
Carvalho, Carlos Eduardo
Humano
Stomach Neoplasms
Proteome
Helicobacter pylori
Herpesvirus 4
Methylation
Neoplasias Gástricas
Proteoma
Helicobacter pylori
Herpesvirus 4
Metilación
Neoplasias Gástricas
Proteoma
Helicobacter pylori
Herpesvirus 4
Metilação
title_short Considerations about gastric cancer proteomics
title_full Considerations about gastric cancer proteomics
title_fullStr Considerations about gastric cancer proteomics
title_full_unstemmed Considerations about gastric cancer proteomics
title_sort Considerations about gastric cancer proteomics
author Carvalho, Carlos Eduardo
author_facet Carvalho, Carlos Eduardo
Mccormick, Thaís Messias
Carvalho, Paulo Costa
Fischer, Juliana de Saldanha da Gama
Aquino, Priscila Ferreira de
Bravo Neto, Guilherme Pinto
Carvalho, Maria da Gloria da Costa
author_role author
author2 Mccormick, Thaís Messias
Carvalho, Paulo Costa
Fischer, Juliana de Saldanha da Gama
Aquino, Priscila Ferreira de
Bravo Neto, Guilherme Pinto
Carvalho, Maria da Gloria da Costa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Carlos Eduardo
Mccormick, Thaís Messias
Carvalho, Paulo Costa
Fischer, Juliana de Saldanha da Gama
Aquino, Priscila Ferreira de
Bravo Neto, Guilherme Pinto
Carvalho, Maria da Gloria da Costa
dc.subject.other.pt_BR.fl_str_mv Humano
topic Humano
Stomach Neoplasms
Proteome
Helicobacter pylori
Herpesvirus 4
Methylation
Neoplasias Gástricas
Proteoma
Helicobacter pylori
Herpesvirus 4
Metilación
Neoplasias Gástricas
Proteoma
Helicobacter pylori
Herpesvirus 4
Metilação
dc.subject.en.pt_BR.fl_str_mv Stomach Neoplasms
Proteome
Helicobacter pylori
Herpesvirus 4
Methylation
dc.subject.es.pt_BR.fl_str_mv Neoplasias Gástricas
Proteoma
Helicobacter pylori
Herpesvirus 4
Metilación
dc.subject.decs.pt_BR.fl_str_mv Neoplasias Gástricas
Proteoma
Helicobacter pylori
Herpesvirus 4
Metilação
description A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-07-28T12:59:35Z
dc.date.available.fl_str_mv 2017-07-28T12:59:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CARVALHO, Carlos Eduardo et al. Considerations about gastric cancer proteomics. Revista do Colégio Brasileiro de Cirurgiões, v. 43, n. 5, p. 395-397, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20438
dc.identifier.issn.pt_BR.fl_str_mv 0100-6991
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/0100-69912016005016
identifier_str_mv CARVALHO, Carlos Eduardo et al. Considerations about gastric cancer proteomics. Revista do Colégio Brasileiro de Cirurgiões, v. 43, n. 5, p. 395-397, 2016.
0100-6991
10.1590/0100-69912016005016
url https://www.arca.fiocruz.br/handle/icict/20438
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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