Considerations about gastric cancer proteomics
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20438 |
Resumo: | A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica. |
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Carvalho, Carlos EduardoMccormick, Thaís MessiasCarvalho, Paulo CostaFischer, Juliana de Saldanha da GamaAquino, Priscila Ferreira deBravo Neto, Guilherme PintoCarvalho, Maria da Gloria da Costa2017-07-28T12:59:35Z2017-07-28T12:59:35Z2016CARVALHO, Carlos Eduardo et al. Considerations about gastric cancer proteomics. Revista do Colégio Brasileiro de Cirurgiões, v. 43, n. 5, p. 395-397, 2016.0100-6991https://www.arca.fiocruz.br/handle/icict/2043810.1590/0100-69912016005016A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica.The frequency of molecular studies aimed to analyze promoter methylation of tumor suppressor genes and global proteomics in gastric carcinogenesis is increasing. Nonetheless, only a few considered the different types of stomach cells, the tumor location and the influence of Helicobacter pylori and Epstein Barr virus infection (EBV). Molecular differences relating to anatomical and histological tumor areas were also recently described. The authors propose a molecular classification of gastric cancer, dividing it into four subtypes: tumors positive for EBV; microsatellite unstable tumors; genomically stable tumors and tumors with chromosomal instability.Department of Pathology. Faculty of Medicine. Federal University of Janeiro. Rio de Janeiro, RJ, Brazil.Department of Pathology. Faculty of Medicine. Federal University of Janeiro. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica e Engenharia de Proteínas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica e Engenharia de Proteínas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Amazonas, AM, Brasil.Department of Surgery. Faculty of Medicine. Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Department of Pathology. Faculty of Medicine. Federal University of Janeiro. Rio de Janeiro, RJ, Brazil.engColégio Brasileiro de CirurgiõesHumanoStomach NeoplasmsProteomeHelicobacter pyloriHerpesvirus 4MethylationNeoplasias GástricasProteomaHelicobacter pyloriHerpesvirus 4MetilaciónNeoplasias GástricasProteomaHelicobacter pyloriHerpesvirus 4MetilaçãoConsiderations about gastric cancer proteomicsConsiderações sobre proteômica no câncer gástricoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20438/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALConsiderations about gastric cancer proteomics.pdfConsiderations about gastric cancer proteomics.pdfapplication/pdf626072https://www.arca.fiocruz.br/bitstream/icict/20438/2/Considerations%20about%20gastric%20cancer%20proteomics.pdfad7ba958118ce570d3def56c2f39fd44MD52TEXTConsiderations about gastric cancer proteomics.pdf.txtConsiderations about gastric cancer proteomics.pdf.txtExtracted texttext/plain10544https://www.arca.fiocruz.br/bitstream/icict/20438/3/Considerations%20about%20gastric%20cancer%20proteomics.pdf.txt6ca5dd45d2fa21d396b048447ea5210eMD53icict/204382019-12-15 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dc.title.pt_BR.fl_str_mv |
Considerations about gastric cancer proteomics |
dc.title.alternative.pt_BR.fl_str_mv |
Considerações sobre proteômica no câncer gástrico |
title |
Considerations about gastric cancer proteomics |
spellingShingle |
Considerations about gastric cancer proteomics Carvalho, Carlos Eduardo Humano Stomach Neoplasms Proteome Helicobacter pylori Herpesvirus 4 Methylation Neoplasias Gástricas Proteoma Helicobacter pylori Herpesvirus 4 Metilación Neoplasias Gástricas Proteoma Helicobacter pylori Herpesvirus 4 Metilação |
title_short |
Considerations about gastric cancer proteomics |
title_full |
Considerations about gastric cancer proteomics |
title_fullStr |
Considerations about gastric cancer proteomics |
title_full_unstemmed |
Considerations about gastric cancer proteomics |
title_sort |
Considerations about gastric cancer proteomics |
author |
Carvalho, Carlos Eduardo |
author_facet |
Carvalho, Carlos Eduardo Mccormick, Thaís Messias Carvalho, Paulo Costa Fischer, Juliana de Saldanha da Gama Aquino, Priscila Ferreira de Bravo Neto, Guilherme Pinto Carvalho, Maria da Gloria da Costa |
author_role |
author |
author2 |
Mccormick, Thaís Messias Carvalho, Paulo Costa Fischer, Juliana de Saldanha da Gama Aquino, Priscila Ferreira de Bravo Neto, Guilherme Pinto Carvalho, Maria da Gloria da Costa |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Carlos Eduardo Mccormick, Thaís Messias Carvalho, Paulo Costa Fischer, Juliana de Saldanha da Gama Aquino, Priscila Ferreira de Bravo Neto, Guilherme Pinto Carvalho, Maria da Gloria da Costa |
dc.subject.other.pt_BR.fl_str_mv |
Humano |
topic |
Humano Stomach Neoplasms Proteome Helicobacter pylori Herpesvirus 4 Methylation Neoplasias Gástricas Proteoma Helicobacter pylori Herpesvirus 4 Metilación Neoplasias Gástricas Proteoma Helicobacter pylori Herpesvirus 4 Metilação |
dc.subject.en.pt_BR.fl_str_mv |
Stomach Neoplasms Proteome Helicobacter pylori Herpesvirus 4 Methylation |
dc.subject.es.pt_BR.fl_str_mv |
Neoplasias Gástricas Proteoma Helicobacter pylori Herpesvirus 4 Metilación |
dc.subject.decs.pt_BR.fl_str_mv |
Neoplasias Gástricas Proteoma Helicobacter pylori Herpesvirus 4 Metilação |
description |
A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-07-28T12:59:35Z |
dc.date.available.fl_str_mv |
2017-07-28T12:59:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Carlos Eduardo et al. Considerations about gastric cancer proteomics. Revista do Colégio Brasileiro de Cirurgiões, v. 43, n. 5, p. 395-397, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20438 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-6991 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/0100-69912016005016 |
identifier_str_mv |
CARVALHO, Carlos Eduardo et al. Considerations about gastric cancer proteomics. Revista do Colégio Brasileiro de Cirurgiões, v. 43, n. 5, p. 395-397, 2016. 0100-6991 10.1590/0100-69912016005016 |
url |
https://www.arca.fiocruz.br/handle/icict/20438 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
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