Is there a role for fibronectin upon true histiocytic lymphoma progression?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28266 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil. |
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Stimamiglio, Marco AugustoBarbosa, Suse Dayse SilvaDomingues, Maria Aparecida CustódioTrentin, Andréa GonçalvesSilva, Marcio AlvarezSavino, Wilson2018-08-21T13:31:10Z2018-08-21T13:31:10Z2008STIMAMIGLIO, Marco Augusto; et al. Is there a role for fibronectin upon true histiocytic lymphoma progression?. International Journal of Oncology, v.33, p.517-524, 2008.1019-6439https://www.arca.fiocruz.br/handle/icict/2826610.3892/ijo_000000351791-2423engSpandidos PublicationsFibronectinasinfonodosMatriz extracelularhistiocytic lymphomaU-937integrinsextracellular matrixFibronectinlymph nodesIntegrinasLinfoma Difuso de Grandes Células BIs there a role for fibronectin upon true histiocytic lymphoma progression?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Centro de Hematologia e Hemoterapia de Santa Catarina. Laboratório de Hemopatologia. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Cell interaction with extracellular matrix is a crucial event for various biological processes, including tumor progression. Although not exclusively, these interactions are frequently mediated by bidirectional signaling receptors known as integrins. Using a human histiocytic lymphomaderived cell line (U-937), we evaluated the effects of ECM proteins and their integrin-type receptors in the regulation of cell attachment, proliferation, migration and survival. Fibronectin induces higher cell attachment in vitro when compared to laminin. Fibronectin also promotes a decrease in cell migration but do not modulate cell proliferation and death. Pre-incubation of U-937 cells with VLA-5 antagonistic peptides inhibited attachment of the cells to fibronectincoated substrates. In a second vein, we observed that lymph node specimens obtained from diagnosed patient for true histiocytic lymphoma had greater deposition of fibronectin (but not laminin) around malignant clones. These results suggest that fibronectins play a relevant role in the establishment and progression of true histiocytic lymphoma cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28266/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALsuse_barbosa_etal_IOC_2008.pdfsuse_barbosa_etal_IOC_2008.pdfapplication/pdf498556https://www.arca.fiocruz.br/bitstream/icict/28266/2/suse_barbosa_etal_IOC_2008.pdf0328d980bcbe05b9e25ed357a76f736cMD52TEXTsuse_barbosa_etal_IOC_2008.pdf.txtsuse_barbosa_etal_IOC_2008.pdf.txtExtracted texttext/plain33437https://www.arca.fiocruz.br/bitstream/icict/28266/3/suse_barbosa_etal_IOC_2008.pdf.txtcc0bc3e7759208c1d49a6dd3a9fd9901MD53icict/282662018-08-22 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| dc.title.pt_BR.fl_str_mv |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| title |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| spellingShingle |
Is there a role for fibronectin upon true histiocytic lymphoma progression? Stimamiglio, Marco Augusto Fibronectinas infonodos Matriz extracelular histiocytic lymphoma U-937 integrins extracellular matrix Fibronectin lymph nodes Integrinas Linfoma Difuso de Grandes Células B |
| title_short |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| title_full |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| title_fullStr |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| title_full_unstemmed |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| title_sort |
Is there a role for fibronectin upon true histiocytic lymphoma progression? |
| author |
Stimamiglio, Marco Augusto |
| author_facet |
Stimamiglio, Marco Augusto Barbosa, Suse Dayse Silva Domingues, Maria Aparecida Custódio Trentin, Andréa Gonçalves Silva, Marcio Alvarez Savino, Wilson |
| author_role |
author |
| author2 |
Barbosa, Suse Dayse Silva Domingues, Maria Aparecida Custódio Trentin, Andréa Gonçalves Silva, Marcio Alvarez Savino, Wilson |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Stimamiglio, Marco Augusto Barbosa, Suse Dayse Silva Domingues, Maria Aparecida Custódio Trentin, Andréa Gonçalves Silva, Marcio Alvarez Savino, Wilson |
| dc.subject.other.pt_BR.fl_str_mv |
Fibronectinas infonodos Matriz extracelular |
| topic |
Fibronectinas infonodos Matriz extracelular histiocytic lymphoma U-937 integrins extracellular matrix Fibronectin lymph nodes Integrinas Linfoma Difuso de Grandes Células B |
| dc.subject.en.pt_BR.fl_str_mv |
histiocytic lymphoma U-937 integrins extracellular matrix Fibronectin lymph nodes |
| dc.subject.decs.pt_BR.fl_str_mv |
Integrinas Linfoma Difuso de Grandes Células B |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil. |
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2008 |
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2008 |
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2018-08-21T13:31:10Z |
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2018-08-21T13:31:10Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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STIMAMIGLIO, Marco Augusto; et al. Is there a role for fibronectin upon true histiocytic lymphoma progression?. International Journal of Oncology, v.33, p.517-524, 2008. |
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https://www.arca.fiocruz.br/handle/icict/28266 |
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1019-6439 |
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10.3892/ijo_00000035 |
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1791-2423 |
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STIMAMIGLIO, Marco Augusto; et al. Is there a role for fibronectin upon true histiocytic lymphoma progression?. International Journal of Oncology, v.33, p.517-524, 2008. 1019-6439 10.3892/ijo_00000035 1791-2423 |
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