Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse

Detalhes bibliográficos
Autor(a) principal: Lima, Camila Bião
Data de Publicação: 2007
Outros Autores: Iglesias, Karen Brasil, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/2805
Resumo: Papes III - Fiocruz, Pronex
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spelling Lima, Camila BiãoIglesias, Karen BrasilAndrade, Zilton de Araújo2011-08-21T00:02:13Z2011-08-21T00:02:13Z2007LIMA, C. B. et al. Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse. Memórias do Instituto Oswaldo Cruz, v. 102, n. 7, p. 883-885, Nov. 20070074-0276https://www.arca.fiocruz.br/handle/icict/2805Papes III - Fiocruz, PronexFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA. BrasilThe relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosisengThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThalidomideSchistosomiasisAngiogenesisFibrosisInibidores da AngiogêneseCirrose HepáticaNeovascularização PatológicaEsquistossomose mansoniFígadoModelos Animais de DoençasCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse.pdfThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse.pdfapplication/pdf185066https://www.arca.fiocruz.br/bitstream/icict/2805/1/Thalidomide%20failed%20to%20inhibit%20angiogenesis%20and%20fibrosis%20in%20hepatic%20schistosomiasis%20of%20the%20mouse.pdfd76702a1a293cc0629ed420158ae96f2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2805/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse.pdf.txtThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse.pdf.txtExtracted texttext/plain9429https://www.arca.fiocruz.br/bitstream/icict/2805/5/Thalidomide%20failed%20to%20inhibit%20angiogenesis%20and%20fibrosis%20in%20hepatic%20schistosomiasis%20of%20the%20mouse.pdf.txt5c7638ff5d467c4cfba9c02de97ea3ceMD55THUMBNAILThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse.pdf.jpgThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse.pdf.jpgGenerated Thumbnailimage/jpeg2307https://www.arca.fiocruz.br/bitstream/icict/2805/4/Thalidomide%20failed%20to%20inhibit%20angiogenesis%20and%20fibrosis%20in%20hepatic%20schistosomiasis%20of%20the%20mouse.pdf.jpg5bdfcdba93f5a0483d8c4f3c4ee211f9MD54icict/28052023-03-15 14:33:01.375oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
spellingShingle Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
Lima, Camila Bião
Thalidomide
Schistosomiasis
Angiogenesis
Fibrosis
Inibidores da Angiogênese
Cirrose Hepática
Neovascularização Patológica
Esquistossomose mansoni
Fígado
Modelos Animais de Doenças
Camundongos
title_short Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_full Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_fullStr Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_full_unstemmed Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
title_sort Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
author Lima, Camila Bião
author_facet Lima, Camila Bião
Iglesias, Karen Brasil
Andrade, Zilton de Araújo
author_role author
author2 Iglesias, Karen Brasil
Andrade, Zilton de Araújo
author2_role author
author
dc.contributor.author.fl_str_mv Lima, Camila Bião
Iglesias, Karen Brasil
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Thalidomide
Schistosomiasis
Angiogenesis
Fibrosis
topic Thalidomide
Schistosomiasis
Angiogenesis
Fibrosis
Inibidores da Angiogênese
Cirrose Hepática
Neovascularização Patológica
Esquistossomose mansoni
Fígado
Modelos Animais de Doenças
Camundongos
dc.subject.decs.pt_BR.fl_str_mv Inibidores da Angiogênese
Cirrose Hepática
Neovascularização Patológica
Esquistossomose mansoni
Fígado
Modelos Animais de Doenças
Camundongos
description Papes III - Fiocruz, Pronex
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2011-08-21T00:02:13Z
dc.date.available.fl_str_mv 2011-08-21T00:02:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, C. B. et al. Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse. Memórias do Instituto Oswaldo Cruz, v. 102, n. 7, p. 883-885, Nov. 2007
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/2805
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv LIMA, C. B. et al. Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse. Memórias do Instituto Oswaldo Cruz, v. 102, n. 7, p. 883-885, Nov. 2007
0074-0276
url https://www.arca.fiocruz.br/handle/icict/2805
dc.language.iso.fl_str_mv eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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