Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions

Detalhes bibliográficos
Autor(a) principal: Lepelletier, Yves
Data de Publicação: 2007
Outros Autores: Smaniotto, Salete, Hadj-Slimane, Réda, Villa-Verde, Déa Maria Serra, Nogueira, Ana Cristina, Dardenne, Mireille, Herminie, Olivier, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33836
Resumo: Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France.
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spelling Lepelletier, YvesSmaniotto, SaleteHadj-Slimane, RédaVilla-Verde, Déa Maria SerraNogueira, Ana CristinaDardenne, MireilleHerminie, OlivierSavino, Wilson2019-07-04T13:42:19Z2019-07-04T13:42:19Z2007LEPELLETIER, Yves et al. Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions. PNAS, v. 104, n. 13, p. 5545-5550, Mar. 2007.0027-8424https://www.arca.fiocruz.br/handle/icict/3383610.1073/pnas.07007051041091-6490engNational Academy of SciencesMatriz ExtracelularAdesão e migração de timócitosIntegrinasExtracellular matrixIntegrinsThymocyte adhesion and migrationIntegrinasControl of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversité René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal de Alagoas. Departamento de Morfologia. Maceió, AL, Brasil.Université Paris V René Descartes. Institut National de la Santé et de la Recherche Médicale Unité 648. Paris, France / TRAGEX Pharma. Tour Reflets. 75015 Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France.Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil /It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involved in peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 during T cell development in the human thymus. NP-1 is expressed in both cortex and medulla of thymic lobules, being found in distinct CD4/CD8-defined thymocyte subsets. NP-1 is also found in thymic epithelial cells (TEC) in situ and in vitro, and is recruited at the site of TEC–thymocyte contact. Moreover, NP-1 was rapidly up-regulated during thymocyte stimulation by T cell receptor (TCR) and IL-7 or after adhesion to TEC. Semaphorin-3A (Sema-3A), a natural ligand of NP-1, is also present in human thymus, both in TEC and thymocytes, being up-regulated in thymocytes after TCR engagement. Functionally, Sema-3A decreases the adhesion capacity of NP-1 thymocytes and induces their migration by a repulsive effect. In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33836/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWlisonSavino_DeaVilaVerde_etal_IOC_2007.pdfWlisonSavino_DeaVilaVerde_etal_IOC_2007.pdfapplication/pdf2949027https://www.arca.fiocruz.br/bitstream/icict/33836/2/WlisonSavino_DeaVilaVerde_etal_IOC_2007.pdfc4e7483be0b16687572de6bba9ffd029MD52TEXTWlisonSavino_DeaVilaVerde_etal_IOC_2007.pdf.txtWlisonSavino_DeaVilaVerde_etal_IOC_2007.pdf.txtExtracted texttext/plain38304https://www.arca.fiocruz.br/bitstream/icict/33836/3/WlisonSavino_DeaVilaVerde_etal_IOC_2007.pdf.txt93807c73b4550661583fb4ade62e66c2MD53icict/338362019-07-05 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dc.title.pt_BR.fl_str_mv Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
title Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
spellingShingle Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
Lepelletier, Yves
Matriz Extracelular
Adesão e migração de timócitos
Integrinas
Extracellular matrix
Integrins
Thymocyte adhesion and migration
Integrinas
title_short Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
title_full Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
title_fullStr Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
title_full_unstemmed Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
title_sort Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
author Lepelletier, Yves
author_facet Lepelletier, Yves
Smaniotto, Salete
Hadj-Slimane, Réda
Villa-Verde, Déa Maria Serra
Nogueira, Ana Cristina
Dardenne, Mireille
Herminie, Olivier
Savino, Wilson
author_role author
author2 Smaniotto, Salete
Hadj-Slimane, Réda
Villa-Verde, Déa Maria Serra
Nogueira, Ana Cristina
Dardenne, Mireille
Herminie, Olivier
Savino, Wilson
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lepelletier, Yves
Smaniotto, Salete
Hadj-Slimane, Réda
Villa-Verde, Déa Maria Serra
Nogueira, Ana Cristina
Dardenne, Mireille
Herminie, Olivier
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Matriz Extracelular
Adesão e migração de timócitos
Integrinas
topic Matriz Extracelular
Adesão e migração de timócitos
Integrinas
Extracellular matrix
Integrins
Thymocyte adhesion and migration
Integrinas
dc.subject.en.pt_BR.fl_str_mv Extracellular matrix
Integrins
Thymocyte adhesion and migration
dc.subject.decs.pt_BR.fl_str_mv Integrinas
description Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2019-07-04T13:42:19Z
dc.date.available.fl_str_mv 2019-07-04T13:42:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEPELLETIER, Yves et al. Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions. PNAS, v. 104, n. 13, p. 5545-5550, Mar. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33836
dc.identifier.issn.pt_BR.fl_str_mv 0027-8424
dc.identifier.doi.pt_BR.fl_str_mv 10.1073/pnas.0700705104
dc.identifier.eissn.none.fl_str_mv 1091-6490
identifier_str_mv LEPELLETIER, Yves et al. Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions. PNAS, v. 104, n. 13, p. 5545-5550, Mar. 2007.
0027-8424
10.1073/pnas.0700705104
1091-6490
url https://www.arca.fiocruz.br/handle/icict/33836
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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