Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model

Detalhes bibliográficos
Autor(a) principal: Oliveira, Felipe P. de
Data de Publicação: 2021
Outros Autores: Rodrigues, Ana Carolina B. da C., Lima, Emilly J. S. P. de, Silva, Valdenizia R., Santos, Luciano de S., Anunciação, Talita A. da, Nogueira, Mateus L., Soares, Milena Botelho Pereira, Dias, Rosane B., Rocha, Clarissa Araujo Gurgel, Duvoisin Junior, Sérgio, Albuquerque, Patrícia M., Lima, Emerson S., Gonçalves, José F. C., Bataglion, Giovana A., Costa, Emmanoel V., Silva, Felipe M. A. da, Koolen, Hector H. F., Bezerra, Daniel Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50190
Resumo: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), 40296-710 Salvador, Bahia, Brazil or, e-mail: danielpbezerra@gmail.com; daniel.bezerra@fiocruz.br b Metabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), 690065-130 Manaus, Amazonas, Brazil or, e-mail: hectorkoolen@gmail.com; hkoolen@uea.edu.br c School of Medicine and School of Dentistry, Federal University of Bahia, 40301-155 Salvador, Bahia, Brazil d Laboratory of Applied Chemistry and Technology, Amazonas State University (UEA), 69050-020 Manaus, Amazonas, Brazil e Faculty of Pharmacy, Federal University of Amazonas (UFAM), 69077-000 Manaus, Amazonas, Brazil f Laboratory of Plant Physiology and Biochemistry, National Institute for Amazonian Research (INPA), 69011-970 Manaus, Amazonas, Brazil g Department of Chemistry, Federal University of Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil h Analytical Center, Multidisciplinary Support Center (CAM), Federal University of Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil
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spelling Oliveira, Felipe P. deRodrigues, Ana Carolina B. da C.Lima, Emilly J. S. P. deSilva, Valdenizia R.Santos, Luciano de S.Anunciação, Talita A. daNogueira, Mateus L.Soares, Milena Botelho PereiraDias, Rosane B.Rocha, Clarissa Araujo GurgelDuvoisin Junior, SérgioAlbuquerque, Patrícia M.Lima, Emerson S.Gonçalves, José F. C.Bataglion, Giovana A.Costa, Emmanoel V.Silva, Felipe M. A. daKoolen, Hector H. F.Bezerra, Daniel Pereira2021-12-07T11:17:51Z2021-12-07T11:17:51Z2021OLIVEIRA, Felipe P. de et al. Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model. Chemistry and Biodiversity, 2021.1612-1872https://www.arca.fiocruz.br/handle/icict/5019010.1002/cbdv.202000938Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), 40296-710 Salvador, Bahia, Brazil or, e-mail: danielpbezerra@gmail.com; daniel.bezerra@fiocruz.br b Metabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), 690065-130 Manaus, Amazonas, Brazil or, e-mail: hectorkoolen@gmail.com; hkoolen@uea.edu.br c School of Medicine and School of Dentistry, Federal University of Bahia, 40301-155 Salvador, Bahia, Brazil d Laboratory of Applied Chemistry and Technology, Amazonas State University (UEA), 69050-020 Manaus, Amazonas, Brazil e Faculty of Pharmacy, Federal University of Amazonas (UFAM), 69077-000 Manaus, Amazonas, Brazil f Laboratory of Plant Physiology and Biochemistry, National Institute for Amazonian Research (INPA), 69011-970 Manaus, Amazonas, Brazil g Department of Chemistry, Federal University of Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil h Analytical Center, Multidisciplinary Support Center (CAM), Federal University of Amazonas (UFAM), 69080-900 Manaus, Amazonas, BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil, finance code 001); Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB, Brazil); and Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM, Brazil)."Múltipla ver em Notas"Aniba parviflora (MEISN.) MEZ (Lauraceae) is an aromatic plant of the Amazon rainforest, which has a tremendous commercial value in the perfumery industry; it is popularly used as flavoring sachets and aromatic baths. In Brazilian folk medicine, A. parviflora is used to treat victims of snakebites. Herein, we analyzed the chemical composition of A. parviflora bark essential oil (EO) and its effect on the growth of human hepatocellular carcinoma HepG2 cells in vitro and in vivo. EO was obtained by hydrodistillation and characterized by GC-MS and GC-FID. The main constituents of EO were linalool (16.3:3.15), α-humulene (14.5:2.41 %), δ-cadinene (10.2: 1.09 %), α-copaene (9.51:1.12%) and germacrene B (7.58:2.15 %). Initially, EO’s cytotoxic effect was evaluated against five cancer cell lines (HepG2, MCF-7, HCT116, HL-60 and B16-F10) and one non-cancerous one (MRC-5), using the Alamar blue method after 72 h of treatment. The calculated IC50 values were 9.05, 22.04, >50, 15.36, 17.57, and 30.46 μg/mL, respectively. The best selectivity was for HepG2 cells with a selective index of 3.4. DNA Fragmentation and cell cycle distribution were quantified in HepG2 cells by flow cytometry after a treatment period of 24 and 48 h. The effect of EO on tumor development in vivo was evaluated in a xenograft model using C.B-17 SCID mice engrafted with HepG2 cells. In vivo tumor growth inhibition of HepG2 xenograft at the doses of 40 and 80 mg/kg were 12.1 and 62.4 %, respectively.engWileyPlantasAgentes antitumoraisCitotoxicidadeCélulas Hep G2LauraceaeAniba parvifloraAntitumor agentsCytotoxicityHepG2LauraceaeEssential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50190/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALOliveira, Felipe P. Essential....pdfOliveira, Felipe P. 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dc.title.pt_BR.fl_str_mv Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
title Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
spellingShingle Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
Oliveira, Felipe P. de
Plantas
Agentes antitumorais
Citotoxicidade
Células Hep G2
Lauraceae
Aniba parviflora
Antitumor agents
Cytotoxicity
HepG2
Lauraceae
title_short Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
title_full Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
title_fullStr Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
title_full_unstemmed Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
title_sort Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
author Oliveira, Felipe P. de
author_facet Oliveira, Felipe P. de
Rodrigues, Ana Carolina B. da C.
Lima, Emilly J. S. P. de
Silva, Valdenizia R.
Santos, Luciano de S.
Anunciação, Talita A. da
Nogueira, Mateus L.
Soares, Milena Botelho Pereira
Dias, Rosane B.
Rocha, Clarissa Araujo Gurgel
Duvoisin Junior, Sérgio
Albuquerque, Patrícia M.
Lima, Emerson S.
Gonçalves, José F. C.
Bataglion, Giovana A.
Costa, Emmanoel V.
Silva, Felipe M. A. da
Koolen, Hector H. F.
Bezerra, Daniel Pereira
author_role author
author2 Rodrigues, Ana Carolina B. da C.
Lima, Emilly J. S. P. de
Silva, Valdenizia R.
Santos, Luciano de S.
Anunciação, Talita A. da
Nogueira, Mateus L.
Soares, Milena Botelho Pereira
Dias, Rosane B.
Rocha, Clarissa Araujo Gurgel
Duvoisin Junior, Sérgio
Albuquerque, Patrícia M.
Lima, Emerson S.
Gonçalves, José F. C.
Bataglion, Giovana A.
Costa, Emmanoel V.
Silva, Felipe M. A. da
Koolen, Hector H. F.
Bezerra, Daniel Pereira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Felipe P. de
Rodrigues, Ana Carolina B. da C.
Lima, Emilly J. S. P. de
Silva, Valdenizia R.
Santos, Luciano de S.
Anunciação, Talita A. da
Nogueira, Mateus L.
Soares, Milena Botelho Pereira
Dias, Rosane B.
Rocha, Clarissa Araujo Gurgel
Duvoisin Junior, Sérgio
Albuquerque, Patrícia M.
Lima, Emerson S.
Gonçalves, José F. C.
Bataglion, Giovana A.
Costa, Emmanoel V.
Silva, Felipe M. A. da
Koolen, Hector H. F.
Bezerra, Daniel Pereira
dc.subject.other.pt_BR.fl_str_mv Plantas
Agentes antitumorais
Citotoxicidade
Células Hep G2
Lauraceae
topic Plantas
Agentes antitumorais
Citotoxicidade
Células Hep G2
Lauraceae
Aniba parviflora
Antitumor agents
Cytotoxicity
HepG2
Lauraceae
dc.subject.en.pt_BR.fl_str_mv Aniba parviflora
Antitumor agents
Cytotoxicity
HepG2
Lauraceae
description Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), 40296-710 Salvador, Bahia, Brazil or, e-mail: danielpbezerra@gmail.com; daniel.bezerra@fiocruz.br b Metabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), 690065-130 Manaus, Amazonas, Brazil or, e-mail: hectorkoolen@gmail.com; hkoolen@uea.edu.br c School of Medicine and School of Dentistry, Federal University of Bahia, 40301-155 Salvador, Bahia, Brazil d Laboratory of Applied Chemistry and Technology, Amazonas State University (UEA), 69050-020 Manaus, Amazonas, Brazil e Faculty of Pharmacy, Federal University of Amazonas (UFAM), 69077-000 Manaus, Amazonas, Brazil f Laboratory of Plant Physiology and Biochemistry, National Institute for Amazonian Research (INPA), 69011-970 Manaus, Amazonas, Brazil g Department of Chemistry, Federal University of Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil h Analytical Center, Multidisciplinary Support Center (CAM), Federal University of Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-07T11:17:51Z
dc.date.available.fl_str_mv 2021-12-07T11:17:51Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Felipe P. de et al. Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model. Chemistry and Biodiversity, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50190
dc.identifier.issn.pt_BR.fl_str_mv 1612-1872
dc.identifier.doi.none.fl_str_mv 10.1002/cbdv.202000938
identifier_str_mv OLIVEIRA, Felipe P. de et al. Essential Oil from Bark of Aniba parviflora (MEISN.) MEZ (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model. Chemistry and Biodiversity, 2021.
1612-1872
10.1002/cbdv.202000938
url https://www.arca.fiocruz.br/handle/icict/50190
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/50190/2/Oliveira%2c%20Felipe%20P.%20Essential....pdf
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