Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.

Detalhes bibliográficos
Autor(a) principal: Pontes-de-Carvalho, Lain Carlos
Data de Publicação: 2002
Outros Autores: Santana, Cláudia Dias de, Soares, Milena Botelho Pereira, Oliveira, Geraldo Gileno de Sá, Cunha Neto, Edecio, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5499
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Pontes-de-Carvalho, Lain CarlosSantana, Cláudia Dias deSoares, Milena Botelho PereiraOliveira, Geraldo Gileno de SáCunha Neto, EdecioSantos, Ricardo Ribeiro dos2012-09-10T20:19:26Z2012-09-10T20:19:26Z2002PONTES-DE-CARVALHO, L. et al. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. Journal of Autoimmunity, v. 18, n. 2, p. 131-8, mar. 2002.0896-8411https://www.arca.fiocruz.br/handle/icict/549910.1006/jaut.2001.0574, available online at http://www.idealibrary.com onengExperimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo Medical School. Heart Institute InCor and Division of Clinical Immunology and Allergy. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe protozoan Trypanosoma cruzi causes chronic Chagas’ disease myocarditis (CCDM) in infected mammals. The pathogenesis of CCDM, however, is still unclear. Indirect evidence for either parasite- or heart-specific immune responses playing a pathogenic role is available. In this work, the participation of autoimmunity in the development of CCDM is demonstrated in mice in which immunological tolerance to heart antigens was induced or strengthened prior to their infection by T. cruzi. Tolerance was induced by heart antigen administration in the presence of complete Freund’s adjuvant and anti-CD4 antibodies. Tolerized mice developed less intense CCDM than control nontolerized animals that had received only anti-CD4 and adjuvant. This result confirms the important notion that tolerance to self, and in particular to heart antigens, may be reinforced/induced in normal animals, and raises the possibility that analogous interventions may prevent the development of CCDM in millions of T. cruzi-infected human beings.Anti-CD4Experimental autoimmune myocarditisChagas’ diseaseTrypanosoma cruziImmunological toleranceDoenças Auto-Imunes/imunologiaDoenças Auto-Imunes/prevenção & controleCardiomiopatia Chagásica/imunologiaCardiomiopatia Chagásica/prevenção & controleAnticorpos Monoclonais/farmacologiaAntígenos CD4/imunologiaAuto-Antígenos/administração & dosagemTolerância ImunológicaAnimaisFemininoHumanosImunossupressãoCamundongosCamundongos Endogâmicos BALB CMiocárdio/imunologiaMiosinas/administração & dosagemMiosinas/imunologiaTrypanosoma cruzi/patogenicidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPontes-de-Carvalho L Experimental chronic Chagas'....pdfPontes-de-Carvalho L Experimental chronic Chagas'....pdfapplication/pdf716646https://www.arca.fiocruz.br/bitstream/icict/5499/1/Pontes-de-Carvalho%20L%20Experimental%20chronic%20Chagas%27....pdf1e6a5862703329b944fbb1ab73bf322aMD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
title Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
spellingShingle Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
Pontes-de-Carvalho, Lain Carlos
Anti-CD4
Experimental autoimmune myocarditis
Chagas’ disease
Trypanosoma cruzi
Immunological tolerance
Doenças Auto-Imunes/imunologia
Doenças Auto-Imunes/prevenção & controle
Cardiomiopatia Chagásica/imunologia
Cardiomiopatia Chagásica/prevenção & controle
Anticorpos Monoclonais/farmacologia
Antígenos CD4/imunologia
Auto-Antígenos/administração & dosagem
Tolerância Imunológica
Animais
Feminino
Humanos
Imunossupressão
Camundongos
Camundongos Endogâmicos BALB C
Miocárdio/imunologia
Miosinas/administração & dosagem
Miosinas/imunologia
Trypanosoma cruzi/patogenicidade
title_short Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
title_full Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
title_fullStr Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
title_full_unstemmed Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
title_sort Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
author Pontes-de-Carvalho, Lain Carlos
author_facet Pontes-de-Carvalho, Lain Carlos
Santana, Cláudia Dias de
Soares, Milena Botelho Pereira
Oliveira, Geraldo Gileno de Sá
Cunha Neto, Edecio
Santos, Ricardo Ribeiro dos
author_role author
author2 Santana, Cláudia Dias de
Soares, Milena Botelho Pereira
Oliveira, Geraldo Gileno de Sá
Cunha Neto, Edecio
Santos, Ricardo Ribeiro dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pontes-de-Carvalho, Lain Carlos
Santana, Cláudia Dias de
Soares, Milena Botelho Pereira
Oliveira, Geraldo Gileno de Sá
Cunha Neto, Edecio
Santos, Ricardo Ribeiro dos
dc.subject.en.pt_BR.fl_str_mv Anti-CD4
Experimental autoimmune myocarditis
Chagas’ disease
Trypanosoma cruzi
Immunological tolerance
topic Anti-CD4
Experimental autoimmune myocarditis
Chagas’ disease
Trypanosoma cruzi
Immunological tolerance
Doenças Auto-Imunes/imunologia
Doenças Auto-Imunes/prevenção & controle
Cardiomiopatia Chagásica/imunologia
Cardiomiopatia Chagásica/prevenção & controle
Anticorpos Monoclonais/farmacologia
Antígenos CD4/imunologia
Auto-Antígenos/administração & dosagem
Tolerância Imunológica
Animais
Feminino
Humanos
Imunossupressão
Camundongos
Camundongos Endogâmicos BALB C
Miocárdio/imunologia
Miosinas/administração & dosagem
Miosinas/imunologia
Trypanosoma cruzi/patogenicidade
dc.subject.decs.pt_BR.fl_str_mv Doenças Auto-Imunes/imunologia
Doenças Auto-Imunes/prevenção & controle
Cardiomiopatia Chagásica/imunologia
Cardiomiopatia Chagásica/prevenção & controle
Anticorpos Monoclonais/farmacologia
Antígenos CD4/imunologia
Auto-Antígenos/administração & dosagem
Tolerância Imunológica
Animais
Feminino
Humanos
Imunossupressão
Camundongos
Camundongos Endogâmicos BALB C
Miocárdio/imunologia
Miosinas/administração & dosagem
Miosinas/imunologia
Trypanosoma cruzi/patogenicidade
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2012-09-10T20:19:26Z
dc.date.available.fl_str_mv 2012-09-10T20:19:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PONTES-DE-CARVALHO, L. et al. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. Journal of Autoimmunity, v. 18, n. 2, p. 131-8, mar. 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5499
dc.identifier.issn.none.fl_str_mv 0896-8411
dc.identifier.doi.none.fl_str_mv 10.1006/jaut.2001.0574, available online at http://www.idealibrary.com on
identifier_str_mv PONTES-DE-CARVALHO, L. et al. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. Journal of Autoimmunity, v. 18, n. 2, p. 131-8, mar. 2002.
0896-8411
10.1006/jaut.2001.0574, available online at http://www.idealibrary.com on
url https://www.arca.fiocruz.br/handle/icict/5499
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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