XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48626 |
Resumo: | Vallve, Maria Lourdes Farré. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000 Leuven, Belgium. 2KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000 Leuven, Belgium. 3Karyopharm Therapeutics, Newton, MA, USA. 4Instituto de Pesquisa Goncalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil. 5HUPES, Federal University of Bahia (UFBA), Salvador-Bahia, Brazil. 6Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan |
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Boons, ElineNogueira, Tatiane C.Dierckx, TimMenezes, Soraya MariaJacquemyn, MaartenTamir, SharonLandesman, YosefVallve, Maria Lourdes FarréBittencourt, Achiléa Lisboa CandidoKataoka, KeisukeOgawa, SeishiSnoeck, RobertAndrei, GracielaVan Weyenbergh, JohanDaelemans, Dirk2021-08-16T11:34:47Z2021-08-16T11:34:47Z2021BOONS, Eline et al. XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis. Blood Cancer Journal, v. 11, p. 1-5, 2021.2044-5385https://www.arca.fiocruz.br/handle/icict/4862610.1038/s41408-021-00409-310.1038/s41408-021-00409-3Vallve, Maria Lourdes Farré. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000 Leuven, Belgium. 2KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000 Leuven, Belgium. 3Karyopharm Therapeutics, Newton, MA, USA. 4Instituto de Pesquisa Goncalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil. 5HUPES, Federal University of Bahia (UFBA), Salvador-Bahia, Brazil. 6Department of Pathology and Tumor Biology, Kyoto University, Kyoto, JapanFWO (grant G0D6817N) and KU Leuven (“Vaast Leysen Leerstoel voor Infectieziekten in Ontwikkelingslanden”). S.O. is supported by Grant-in-Aid from the Japan Agency for Medical Research and Development [JP119cm0106501h0004, JP119cm0106501h0004], Grant-in-Aid for Scientific Research (KAKENHI 15H05909).KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000. Leuven, Belgium.Karyopharm Therapeutics. Newton, MA, USA.Karyopharm Therapeutics. Newton, MA, USA.Oswaldo Cruz Foundation. Instituto de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.Federal University of Bahia. HUPES. Salvador, BA, Brazil.Kyoto University. Department of Pathology and Tumor Biology. Kyoto, Japan. .Kyoto University. Department of Pathology and Tumor Biology. Kyoto, Japan.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000. Leuven, Belgium.KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000. Leuven, Belgium.engSpringer NatureLeucemia de Células TLinfoma Difuso de Grandes Células BNeoplasiasVírus Linfotrópico T Tipo 1 HumanoLeukemia, TCellLymphoma, Large B-Cell, DiffuseNeoplasmsHuman T-lymphotropic virus 1XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48626/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBoons, Eline XPO1 inhibitors....pdfBoons, Eline XPO1 inhibitors....pdfapplication/pdf666820https://www.arca.fiocruz.br/bitstream/icict/48626/2/Boons%2c%20Eline%20XPO1%20inhibitors....pdf85bcca182536fc847f6abab4bdeab1a3MD52TEXTBoons, Eline XPO1 inhibitors....pdf.txtBoons, 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dc.title.pt_BR.fl_str_mv |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
title |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
spellingShingle |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis Boons, Eline Leucemia de Células T Linfoma Difuso de Grandes Células B Neoplasias Vírus Linfotrópico T Tipo 1 Humano Leukemia, TCell Lymphoma, Large B-Cell, Diffuse Neoplasms Human T-lymphotropic virus 1 |
title_short |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
title_full |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
title_fullStr |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
title_full_unstemmed |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
title_sort |
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis |
author |
Boons, Eline |
author_facet |
Boons, Eline Nogueira, Tatiane C. Dierckx, Tim Menezes, Soraya Maria Jacquemyn, Maarten Tamir, Sharon Landesman, Yosef Vallve, Maria Lourdes Farré Bittencourt, Achiléa Lisboa Candido Kataoka, Keisuke Ogawa, Seishi Snoeck, Robert Andrei, Graciela Van Weyenbergh, Johan Daelemans, Dirk |
author_role |
author |
author2 |
Nogueira, Tatiane C. Dierckx, Tim Menezes, Soraya Maria Jacquemyn, Maarten Tamir, Sharon Landesman, Yosef Vallve, Maria Lourdes Farré Bittencourt, Achiléa Lisboa Candido Kataoka, Keisuke Ogawa, Seishi Snoeck, Robert Andrei, Graciela Van Weyenbergh, Johan Daelemans, Dirk |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Boons, Eline Nogueira, Tatiane C. Dierckx, Tim Menezes, Soraya Maria Jacquemyn, Maarten Tamir, Sharon Landesman, Yosef Vallve, Maria Lourdes Farré Bittencourt, Achiléa Lisboa Candido Kataoka, Keisuke Ogawa, Seishi Snoeck, Robert Andrei, Graciela Van Weyenbergh, Johan Daelemans, Dirk |
dc.subject.other.pt_BR.fl_str_mv |
Leucemia de Células T Linfoma Difuso de Grandes Células B Neoplasias Vírus Linfotrópico T Tipo 1 Humano |
topic |
Leucemia de Células T Linfoma Difuso de Grandes Células B Neoplasias Vírus Linfotrópico T Tipo 1 Humano Leukemia, TCell Lymphoma, Large B-Cell, Diffuse Neoplasms Human T-lymphotropic virus 1 |
dc.subject.en.pt_BR.fl_str_mv |
Leukemia, TCell Lymphoma, Large B-Cell, Diffuse Neoplasms Human T-lymphotropic virus 1 |
description |
Vallve, Maria Lourdes Farré. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000 Leuven, Belgium. 2KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000 Leuven, Belgium. 3Karyopharm Therapeutics, Newton, MA, USA. 4Instituto de Pesquisa Goncalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil. 5HUPES, Federal University of Bahia (UFBA), Salvador-Bahia, Brazil. 6Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-16T11:34:47Z |
dc.date.available.fl_str_mv |
2021-08-16T11:34:47Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
BOONS, Eline et al. XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis. Blood Cancer Journal, v. 11, p. 1-5, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/48626 |
dc.identifier.issn.pt_BR.fl_str_mv |
2044-5385 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1038/s41408-021-00409-3 |
dc.identifier.eissn.none.fl_str_mv |
10.1038/s41408-021-00409-3 |
identifier_str_mv |
BOONS, Eline et al. XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53- mediated caspase-dependent apoptosis. Blood Cancer Journal, v. 11, p. 1-5, 2021. 2044-5385 10.1038/s41408-021-00409-3 |
url |
https://www.arca.fiocruz.br/handle/icict/48626 |
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eng |
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eng |
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Springer Nature |
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Springer Nature |
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