New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40993 |
Resumo: | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
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Macedo, Cristiana Santos deLara, Flavio AlvesPinheiro, Roberta OlmoSchmitz, VeronicaPinho, Marcia de BerrêdoPereira, Geraldo MouraPessolani, Maria Cristina Vidal2020-04-27T17:36:52Z2020-04-27T17:36:52Z2020MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020.2046-1402https://www.arca.fiocruz.br/handle/icict/4099310.12688/f1000research.21383.1engF1000ResearchHanseníaseTolerância a doençasMetabolismoResposta imuneLipídiosCélulas T reguladorMicobactéiaLeprosyDisease toleranceMetabolismImmune responseRegulatory T cellsLipidsMycobacteriumNew insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Chronic infection by the obligate intracellular pathogen Mycobacterium leprae may lead to the development of leprosy. Of note, in the lepromatous clinical form of the disease, failure of the immune system to constrain infection allows the pathogen to reproduce to very high numbers with minimal clinical signs, favoring transmission. The bacillus can modulate cellular metabolism to support its survival, and these changes directly influence immune responses, leading to host tolerance, permanent disease, and dissemination. Among the metabolic changes, upregulation of cholesterol, phospholipids, and fatty acid biosynthesis is particularly important, as it leads to lipid accumulation in the host cells (macrophages and Schwann cells) in the form of lipid droplets, which are sites of polyunsaturated fatty acid–derived lipid mediator biosynthesis that modulate the inflammatory and immune responses. In Schwann cells, energy metabolism is also subverted to support a lipogenic environment. Furthermore, effects on tryptophan and iron metabolisms favor pathogen survival with moderate tissue damage. This review discusses the implications of metabolic changes on the course of M. leprae infection and host immune response and emphasizes the induction of regulatory T cells, which may play a pivotal role in immune modulation in leprosy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40993/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaCVI_Pessolani_etal_IOC_2020.pdfMariaCVI_Pessolani_etal_IOC_2020.pdfapplication/pdf1348998https://www.arca.fiocruz.br/bitstream/icict/40993/2/MariaCVI_Pessolani_etal_IOC_2020.pdf6acdfedcfc111062e1d9959050eaa9aeMD52TEXTMariaCVI_Pessolani_etal_IOC_2020.pdf.txtMariaCVI_Pessolani_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
title |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
spellingShingle |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] Macedo, Cristiana Santos de Hanseníase Tolerância a doenças Metabolismo Resposta imune Lipídios Células T regulador Micobactéia Leprosy Disease tolerance Metabolism Immune response Regulatory T cells Lipids Mycobacterium |
title_short |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
title_full |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
title_fullStr |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
title_full_unstemmed |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
title_sort |
New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] |
author |
Macedo, Cristiana Santos de |
author_facet |
Macedo, Cristiana Santos de Lara, Flavio Alves Pinheiro, Roberta Olmo Schmitz, Veronica Pinho, Marcia de Berrêdo Pereira, Geraldo Moura Pessolani, Maria Cristina Vidal |
author_role |
author |
author2 |
Lara, Flavio Alves Pinheiro, Roberta Olmo Schmitz, Veronica Pinho, Marcia de Berrêdo Pereira, Geraldo Moura Pessolani, Maria Cristina Vidal |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Macedo, Cristiana Santos de Lara, Flavio Alves Pinheiro, Roberta Olmo Schmitz, Veronica Pinho, Marcia de Berrêdo Pereira, Geraldo Moura Pessolani, Maria Cristina Vidal |
dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Tolerância a doenças Metabolismo Resposta imune Lipídios Células T regulador Micobactéia |
topic |
Hanseníase Tolerância a doenças Metabolismo Resposta imune Lipídios Células T regulador Micobactéia Leprosy Disease tolerance Metabolism Immune response Regulatory T cells Lipids Mycobacterium |
dc.subject.en.pt_BR.fl_str_mv |
Leprosy Disease tolerance Metabolism Immune response Regulatory T cells Lipids Mycobacterium |
description |
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-04-27T17:36:52Z |
dc.date.available.fl_str_mv |
2020-04-27T17:36:52Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/40993 |
dc.identifier.issn.pt_BR.fl_str_mv |
2046-1402 |
dc.identifier.doi.none.fl_str_mv |
10.12688/f1000research.21383.1 |
identifier_str_mv |
MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020. 2046-1402 10.12688/f1000research.21383.1 |
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https://www.arca.fiocruz.br/handle/icict/40993 |
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