New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]

Macedo, Cristiana Santos de; Lara, Flavio Alves; Pinheiro, Roberta Olmo; Schmitz, Veronica; Pinho, Marcia de Berrêdo; Pereira, Geraldo Moura; Pessolani, Maria Cristina Vidal

New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]

Detalhes bibliográficos
Autor(a) principal:	Macedo, Cristiana Santos de
Data de Publicação:	2020
Outros Autores:	Lara, Flavio Alves, Pinheiro, Roberta Olmo, Schmitz, Veronica, Pinho, Marcia de Berrêdo, Pereira, Geraldo Moura, Pessolani, Maria Cristina Vidal
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/40993
Resumo:	Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.

Metadados do item

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spelling	Macedo, Cristiana Santos deLara, Flavio AlvesPinheiro, Roberta OlmoSchmitz, VeronicaPinho, Marcia de BerrêdoPereira, Geraldo MouraPessolani, Maria Cristina Vidal2020-04-27T17:36:52Z2020-04-27T17:36:52Z2020MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020.2046-1402https://www.arca.fiocruz.br/handle/icict/4099310.12688/f1000research.21383.1engF1000ResearchHanseníaseTolerância a doençasMetabolismoResposta imuneLipídiosCélulas T reguladorMicobactéiaLeprosyDisease toleranceMetabolismImmune responseRegulatory T cellsLipidsMycobacteriumNew insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Chronic infection by the obligate intracellular pathogen Mycobacterium leprae may lead to the development of leprosy. Of note, in the lepromatous clinical form of the disease, failure of the immune system to constrain infection allows the pathogen to reproduce to very high numbers with minimal clinical signs, favoring transmission. The bacillus can modulate cellular metabolism to support its survival, and these changes directly influence immune responses, leading to host tolerance, permanent disease, and dissemination. Among the metabolic changes, upregulation of cholesterol, phospholipids, and fatty acid biosynthesis is particularly important, as it leads to lipid accumulation in the host cells (macrophages and Schwann cells) in the form of lipid droplets, which are sites of polyunsaturated fatty acid–derived lipid mediator biosynthesis that modulate the inflammatory and immune responses. In Schwann cells, energy metabolism is also subverted to support a lipogenic environment. Furthermore, effects on tryptophan and iron metabolisms favor pathogen survival with moderate tissue damage. This review discusses the implications of metabolic changes on the course of M. leprae infection and host immune response and emphasizes the induction of regulatory T cells, which may play a pivotal role in immune modulation in leprosy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40993/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaCVI_Pessolani_etal_IOC_2020.pdfMariaCVI_Pessolani_etal_IOC_2020.pdfapplication/pdf1348998https://www.arca.fiocruz.br/bitstream/icict/40993/2/MariaCVI_Pessolani_etal_IOC_2020.pdf6acdfedcfc111062e1d9959050eaa9aeMD52TEXTMariaCVI_Pessolani_etal_IOC_2020.pdf.txtMariaCVI_Pessolani_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
title	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
spellingShingle	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] Macedo, Cristiana Santos de Hanseníase Tolerância a doenças Metabolismo Resposta imune Lipídios Células T regulador Micobactéia Leprosy Disease tolerance Metabolism Immune response Regulatory T cells Lipids Mycobacterium
title_short	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
title_full	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
title_fullStr	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
title_full_unstemmed	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
title_sort	New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]
author	Macedo, Cristiana Santos de
author_facet	Macedo, Cristiana Santos de Lara, Flavio Alves Pinheiro, Roberta Olmo Schmitz, Veronica Pinho, Marcia de Berrêdo Pereira, Geraldo Moura Pessolani, Maria Cristina Vidal
author_role	author
author2	Lara, Flavio Alves Pinheiro, Roberta Olmo Schmitz, Veronica Pinho, Marcia de Berrêdo Pereira, Geraldo Moura Pessolani, Maria Cristina Vidal
author2_role	author author author author author author
dc.contributor.author.fl_str_mv	Macedo, Cristiana Santos de Lara, Flavio Alves Pinheiro, Roberta Olmo Schmitz, Veronica Pinho, Marcia de Berrêdo Pereira, Geraldo Moura Pessolani, Maria Cristina Vidal
dc.subject.other.pt_BR.fl_str_mv	Hanseníase Tolerância a doenças Metabolismo Resposta imune Lipídios Células T regulador Micobactéia
topic	Hanseníase Tolerância a doenças Metabolismo Resposta imune Lipídios Células T regulador Micobactéia Leprosy Disease tolerance Metabolism Immune response Regulatory T cells Lipids Mycobacterium
dc.subject.en.pt_BR.fl_str_mv	Leprosy Disease tolerance Metabolism Immune response Regulatory T cells Lipids Mycobacterium
description	Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate	2020
dc.date.accessioned.fl_str_mv	2020-04-27T17:36:52Z
dc.date.available.fl_str_mv	2020-04-27T17:36:52Z
dc.date.issued.fl_str_mv	2020
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/40993
dc.identifier.issn.pt_BR.fl_str_mv	2046-1402
dc.identifier.doi.none.fl_str_mv	10.12688/f1000research.21383.1
identifier_str_mv	MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020. 2046-1402 10.12688/f1000research.21383.1
url	https://www.arca.fiocruz.br/handle/icict/40993
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	F1000Research
publisher.none.fl_str_mv	F1000Research
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]

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