Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Marcio Lourenço
Data de Publicação: 2016
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27668
Resumo: Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.
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spelling Rodrigues, Marcio Lourenço2018-07-26T13:01:47Z2018-07-26T13:01:47Z2016RODRIGUES, Marcio L. Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis. PLoS Neglected Tropical Disease, v. 10, n. 3, p. 1-4, 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/2766810.1371/journal.pntd.0004429engPLOSCriptococcoseInovaçãoFinanciamentoDoenças negligenciadasFunding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.It is estimated that fungal infections cause 1 million deaths annually, accounting for 50% of all AIDS-related deaths. In this specific patient group, data from 2009 revealed that fungal meningitis is responsible for approximately 500,000 deaths each year. The most common fungal pathogen infecting the brain is Cryptococcus neoformans, a yeast- like pathogen that is highly efficient in causing damage to immunosuppressed human hosts. The fungus, which is widespread in the environment, primarily reaches the lung after inhalation of environmental cells and disseminates to the brain in the immunosuppressed host. Clinical studies in humans in combination with animal models of neurological cryptococcosis enabled the classification of the disease into different syndromes, including meningitis, encephalitis, meningoencephalitis, ventriculitis, increased intracranial pressure, and space-occupying lesions. According to the Centers for Disease Control and Prevention (CDC) of the United States, cryptococcal meningitis is a global problem. Estimates by Park and colleagues indicated that approximately 957,900 cases (range, 371,700 – 1,544,000) of cryptococcal meningitis occur each year, resulting in 624,700 deaths (range, 125,000 – 1,124,900) by three months after infection. Currently, estimates of global disease burden, including disability-adjusted life year (DALY), are not available, since cryptococcosis is not separately reported. 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dc.title.pt_BR.fl_str_mv Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
title Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
spellingShingle Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
Rodrigues, Marcio Lourenço
Criptococcose
Inovação
Financiamento
Doenças negligenciadas
title_short Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
title_full Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
title_fullStr Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
title_full_unstemmed Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
title_sort Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis
author Rodrigues, Marcio Lourenço
author_facet Rodrigues, Marcio Lourenço
author_role author
dc.contributor.author.fl_str_mv Rodrigues, Marcio Lourenço
dc.subject.other.pt_BR.fl_str_mv Criptococcose
Inovação
Financiamento
Doenças negligenciadas
topic Criptococcose
Inovação
Financiamento
Doenças negligenciadas
description Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2018-07-26T13:01:47Z
dc.date.available.fl_str_mv 2018-07-26T13:01:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Marcio L. Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis. PLoS Neglected Tropical Disease, v. 10, n. 3, p. 1-4, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27668
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0004429
identifier_str_mv RODRIGUES, Marcio L. Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis. PLoS Neglected Tropical Disease, v. 10, n. 3, p. 1-4, 2016.
1935-2727
10.1371/journal.pntd.0004429
url https://www.arca.fiocruz.br/handle/icict/27668
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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