Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17764 |
Resumo: | Intramuralto-India Program, NIAID, NIH, USA and by the Indian Council of Medical Research, India. Fundação de Amparo à Pesquisa do Estado da Bahia / Fundação Oswaldo Cruz, Brazil. |
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Narendran, GopalanKavitha, DhanasekaranKarunaianantham, RameshSantana, Leonardo GilAlmeida Junior, Jilson Leão deReddy, Sirasanambatti DevarajuluKumar, Marimuthu MakeshHemalatha, HaribabuJayanthi, Nagesh NaliniRavichandran, NarayananKrishnaraja, RajaPrabhakar, AngamuthuManoharan, TamizhselvanNithyananthan, LokeswaranArjunan, GunasundariNatrajan, MohanSwaminathan, SoumyaAndrade, Bruno de Bezerril2017-02-09T12:52:12Z2017-02-09T12:52:12Z2016NARENDRAN, G. et al. Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV. Plos One, v. 11, n. 9, p. e0163298, 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1776410.1371/journal.pone.0163298Intramuralto-India Program, NIAID, NIH, USA and by the Indian Council of Medical Research, India. Fundação de Amparo à Pesquisa do Estado da Bahia / Fundação Oswaldo Cruz, Brazil.National Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrasilNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaGovernment Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, IndiaGovernment Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, IndiaGovernment Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, IndiaGovernment Vellore Medical College and Hospital. Vellore, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, India / India Council of Medical Research. Department of Health Research Ministry of Health and FamilyWelfare. Health secretary. New Delhi, IndiaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrasilParadoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and pro-inflammatory LTB4, with direct implications in TB-driven inflammation. In humans, a single nucleotide polymorphism (SNP) in the LTA4H promoter which regulates its transcriptional activity (rs17525495) has been identified and described to impact clinical severity of TB presentation and response to corticosteroid therapy. Notably, the role of LTA4H on TB-IRIS has not been previously evaluated. Here, we performed an exploratory investigation testing the association of LTA4H polymorphism with respect to frequency of TB-IRIS occurrence and severity of TB-IRIS presentation in HIV-TB co-infected individuals.engPublic Library of ScienceTuberculoseHIVHumanosInflamaçãoPolimorfismoSíndrome inflamatória da reconstituição imuneTuberculosisHIVHumanInflammationPolymorphismImmune reconstitution inflammatory syndromeRole of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17764/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNarendran g Role of LTA4H 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| dc.title.pt_BR.fl_str_mv |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| title |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| spellingShingle |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV Narendran, Gopalan Tuberculose HIV Humanos Inflamação Polimorfismo Síndrome inflamatória da reconstituição imune Tuberculosis HIV Human Inflammation Polymorphism Immune reconstitution inflammatory syndrome |
| title_short |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| title_full |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| title_fullStr |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| title_full_unstemmed |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| title_sort |
Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV |
| author |
Narendran, Gopalan |
| author_facet |
Narendran, Gopalan Kavitha, Dhanasekaran Karunaianantham, Ramesh Santana, Leonardo Gil Almeida Junior, Jilson Leão de Reddy, Sirasanambatti Devarajulu Kumar, Marimuthu Makesh Hemalatha, Haribabu Jayanthi, Nagesh Nalini Ravichandran, Narayanan Krishnaraja, Raja Prabhakar, Angamuthu Manoharan, Tamizhselvan Nithyananthan, Lokeswaran Arjunan, Gunasundari Natrajan, Mohan Swaminathan, Soumya Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Kavitha, Dhanasekaran Karunaianantham, Ramesh Santana, Leonardo Gil Almeida Junior, Jilson Leão de Reddy, Sirasanambatti Devarajulu Kumar, Marimuthu Makesh Hemalatha, Haribabu Jayanthi, Nagesh Nalini Ravichandran, Narayanan Krishnaraja, Raja Prabhakar, Angamuthu Manoharan, Tamizhselvan Nithyananthan, Lokeswaran Arjunan, Gunasundari Natrajan, Mohan Swaminathan, Soumya Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Narendran, Gopalan Kavitha, Dhanasekaran Karunaianantham, Ramesh Santana, Leonardo Gil Almeida Junior, Jilson Leão de Reddy, Sirasanambatti Devarajulu Kumar, Marimuthu Makesh Hemalatha, Haribabu Jayanthi, Nagesh Nalini Ravichandran, Narayanan Krishnaraja, Raja Prabhakar, Angamuthu Manoharan, Tamizhselvan Nithyananthan, Lokeswaran Arjunan, Gunasundari Natrajan, Mohan Swaminathan, Soumya Andrade, Bruno de Bezerril |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose HIV Humanos Inflamação Polimorfismo Síndrome inflamatória da reconstituição imune |
| topic |
Tuberculose HIV Humanos Inflamação Polimorfismo Síndrome inflamatória da reconstituição imune Tuberculosis HIV Human Inflammation Polymorphism Immune reconstitution inflammatory syndrome |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis HIV Human Inflammation Polymorphism Immune reconstitution inflammatory syndrome |
| description |
Intramuralto-India Program, NIAID, NIH, USA and by the Indian Council of Medical Research, India. Fundação de Amparo à Pesquisa do Estado da Bahia / Fundação Oswaldo Cruz, Brazil. |
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2016 |
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2016 |
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2017-02-09T12:52:12Z |
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2017-02-09T12:52:12Z |
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NARENDRAN, G. et al. Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV. Plos One, v. 11, n. 9, p. e0163298, 2016. |
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https://www.arca.fiocruz.br/handle/icict/17764 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0163298 |
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NARENDRAN, G. et al. Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV. Plos One, v. 11, n. 9, p. e0163298, 2016. 1932-6203 10.1371/journal.pone.0163298 |
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Public Library of Science |
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