Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV

Detalhes bibliográficos
Autor(a) principal: Vinhaes, Caian L.
Data de Publicação: 2021
Outros Autores: Pereira, Mariana Araujo, Tibúrcio, Rafael, Cubillos-Angulo, Juan Manuel, Demitto, Fernanda O., Akrami, Kevan M., Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46252
Resumo: Intramural Research Program of the Fundação Oswaldo Cruz, Brazil. The work of Caian Vinhes was supported by MONSTER Initiative and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mariana Araújo-Pereira, Rafael Tibúrcio and Juan Cubillos-Angulo were supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PhD fellowship. Finance code 001). Bruno Andrade is a senior fellow from CNPq and was also supported by the National Institutes of Allergy and Infectious Diseases, USA (U01-AI115940).
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spelling Vinhaes, Caian L.Pereira, Mariana AraujoTibúrcio, RafaelCubillos-Angulo, Juan ManuelDemitto, Fernanda O.Akrami, Kevan M.Andrade, Bruno de Bezerril2021-03-04T12:03:06Z2021-03-04T12:03:06Z2021VINHAES, Caian L. et al. Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV. Life, v. 11, 2021.2075-1729https://www.arca.fiocruz.br/handle/icict/4625210.3390/life11010065Intramural Research Program of the Fundação Oswaldo Cruz, Brazil. The work of Caian Vinhes was supported by MONSTER Initiative and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mariana Araújo-Pereira, Rafael Tibúrcio and Juan Cubillos-Angulo were supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PhD fellowship. Finance code 001). Bruno Andrade is a senior fellow from CNPq and was also supported by the National Institutes of Allergy and Infectious Diseases, USA (U01-AI115940).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil .Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / University of California. Department of Medicine. Divisions of Infectious Diseases and Pulmonary, Critical Care and Sleep Medicine. San Diego, CA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brazil.Antiretroviral therapy (ART) has represented a major advancement in the care of people living with HIV (PLWHH), resulting in significant reductions in morbidity and mortality through immune reconstitution and attenuation of homeostatic disruption. Importantly, restoration of immune function in PLWH with opportunistic infections occasionally leads to an intense and uncontrolled cytokine storm following ART initiation known as immune reconstitution inflammatory syndrome (IRIS). IRIS occurrence is associated with the severe and rapid clinical deterioration that results in significant morbidity and mortality. Here, we detail the determinants underlying IRIS development in PLWH, compiling the available knowledge in the field to highlight details of the inflammatory responses in IRIS associated with the most commonly reported opportunistic pathogens. This review also highlights gaps in the understanding of IRIS pathogenesis and summarizes therapeutic strategies that have been used for IRIS.engMDPIInflamaçãoMortalidadeHIVSíndrome Inflamatória da Reconstituição ImuneSystemic inflammationMycobacteriaHIVImmune reconstitution inflammatory syndrome (IRIS)Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46252/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALVinhaes, Caian L Systematic....pdfVinhaes, Caian L 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dc.title.pt_BR.fl_str_mv Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
title Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
spellingShingle Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
Vinhaes, Caian L.
Inflamação
Mortalidade
HIV
Síndrome Inflamatória da Reconstituição Imune
Systemic inflammation
Mycobacteria
HIV
Immune reconstitution inflammatory syndrome (IRIS)
title_short Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
title_full Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
title_fullStr Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
title_full_unstemmed Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
title_sort Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
author Vinhaes, Caian L.
author_facet Vinhaes, Caian L.
Pereira, Mariana Araujo
Tibúrcio, Rafael
Cubillos-Angulo, Juan Manuel
Demitto, Fernanda O.
Akrami, Kevan M.
Andrade, Bruno de Bezerril
author_role author
author2 Pereira, Mariana Araujo
Tibúrcio, Rafael
Cubillos-Angulo, Juan Manuel
Demitto, Fernanda O.
Akrami, Kevan M.
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vinhaes, Caian L.
Pereira, Mariana Araujo
Tibúrcio, Rafael
Cubillos-Angulo, Juan Manuel
Demitto, Fernanda O.
Akrami, Kevan M.
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Inflamação
Mortalidade
HIV
Síndrome Inflamatória da Reconstituição Imune
topic Inflamação
Mortalidade
HIV
Síndrome Inflamatória da Reconstituição Imune
Systemic inflammation
Mycobacteria
HIV
Immune reconstitution inflammatory syndrome (IRIS)
dc.subject.en.pt_BR.fl_str_mv Systemic inflammation
Mycobacteria
HIV
Immune reconstitution inflammatory syndrome (IRIS)
description Intramural Research Program of the Fundação Oswaldo Cruz, Brazil. The work of Caian Vinhes was supported by MONSTER Initiative and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mariana Araújo-Pereira, Rafael Tibúrcio and Juan Cubillos-Angulo were supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PhD fellowship. Finance code 001). Bruno Andrade is a senior fellow from CNPq and was also supported by the National Institutes of Allergy and Infectious Diseases, USA (U01-AI115940).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-04T12:03:06Z
dc.date.available.fl_str_mv 2021-03-04T12:03:06Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv VINHAES, Caian L. et al. Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV. Life, v. 11, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46252
dc.identifier.issn.pt_BR.fl_str_mv 2075-1729
dc.identifier.doi.none.fl_str_mv 10.3390/life11010065
identifier_str_mv VINHAES, Caian L. et al. Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV. Life, v. 11, 2021.
2075-1729
10.3390/life11010065
url https://www.arca.fiocruz.br/handle/icict/46252
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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