Preparing for long-acting PrEP delivery: building on lessons from oral PrEP

Detalhes bibliográficos
Autor(a) principal: Celum, Connie
Data de Publicação: 2023
Outros Autores: Grinsztejn, Beatriz, Ngure, Kenneth
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60672
Resumo: Departments of Global Health, Medicine, and Epidemiology. University of Washington. Seattle, Washington, USA.
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spelling Celum, ConnieGrinsztejn, BeatrizNgure, Kenneth2023-10-03T17:01:14Z2023-10-03T17:01:14Z2023CELUM, Connie; GRINSZTEJN, Beatriz; NGURE, Kenneth. Preparing for long-acting PrEP delivery: building on lessons from oral PrEP. Journal of the International AIDS Society, Suppl. 2, 1-7, Jul. 2023.1758-2652https://www.arca.fiocruz.br/handle/icict/6067210.1002/jia2.261031758-2652engJohn Wiley & SonsPreparing for long-acting PrEP delivery: building on lessons from oral PrEPinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartments of Global Health, Medicine, and Epidemiology. University of Washington. Seattle, Washington, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.School of Public Health. Jomo Kenyatta University of Agriculture and Technology. Nairobi, KenyaIntroduction: With recent approvals of long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the form of injectable cabotegravir and the dapivirine ring, programmes need to consider how to optimize the delivery of PrEP methods, including by leveraging lessons from the past decade of oral PrEP delivery. Discussion: Framed around differentiated service delivery building blocks, the major considerations for the delivery of LA PrEP are how to reach the populations who would most benefit from PrEP, where to locate PrEP services, how to reduce the user burden of accessing and continuing with PrEP, and how to integrate PrEP with other services. Demand creation for LA PrEP and education about new LA PrEP options should be co-developed with communities and be positively framed. Client-facing clinical decision support tools provide information about HIV prevention and PrEP options in non-technical ways and can support their informed decision-making about PrEP. Training for providers is needed to increase their ability to ask about sexual and drug use behaviours in a non-judgmental and comfortable manner as part of risk assessment, discuss harm reduction strategies and counsel about available PrEP options that fit clients' circumstances and needs. PrEP adherence support should include supportive counselling and be tailored to address an individual's particular barriers and needs. Reminders through text messaging or calls can foster PrEP persistence, given the narrow the window around dosing for injectable cabotegravir. Strategies are needed to expand PrEP delivery options, including telePrEP, pharmacy-based PrEP, key population-led services and mobile venues. Integrated delivery models are needed which include sexually transmitted infection testing and treatment, contraception for cis-women not desiring to become pregnant, PrEP for pregnant women in high HIV prevalence settings, and gender-affirming hormones and support for transgender persons. Conclusions: The outcome of expanding PrEP options through LA PrEP formulations is to increase PrEP coverage, adherence, persistence and effectiveness by offering a choice of PrEP that meets the needs of persons who would benefit from PrEP. The lessons learned from the delivery of oral PrEP about demand creation, informed client decision-making, provider training, adherence support and service delivery model are relevant to the delivery of LA PrEP and integration with other services.HIV pre-exposure prophylaxisAdherenceDeliveryLessonsLong-actingPersistenceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60672/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Connie_Celum_etal_INI_2023.pdfve_Connie_Celum_etal_INI_2023.pdfapplication/pdf200328https://www.arca.fiocruz.br/bitstream/icict/60672/2/ve_Connie_Celum_etal_INI_2023.pdf5578af3015befbcaba00a864882661d1MD52icict/606722023-10-03 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dc.title.en_US.fl_str_mv Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
title Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
spellingShingle Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
Celum, Connie
HIV pre-exposure prophylaxis
Adherence
Delivery
Lessons
Long-acting
Persistence
title_short Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
title_full Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
title_fullStr Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
title_full_unstemmed Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
title_sort Preparing for long-acting PrEP delivery: building on lessons from oral PrEP
author Celum, Connie
author_facet Celum, Connie
Grinsztejn, Beatriz
Ngure, Kenneth
author_role author
author2 Grinsztejn, Beatriz
Ngure, Kenneth
author2_role author
author
dc.contributor.author.fl_str_mv Celum, Connie
Grinsztejn, Beatriz
Ngure, Kenneth
dc.subject.en.en_US.fl_str_mv HIV pre-exposure prophylaxis
Adherence
Delivery
Lessons
Long-acting
Persistence
topic HIV pre-exposure prophylaxis
Adherence
Delivery
Lessons
Long-acting
Persistence
description Departments of Global Health, Medicine, and Epidemiology. University of Washington. Seattle, Washington, USA.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-10-03T17:01:14Z
dc.date.available.fl_str_mv 2023-10-03T17:01:14Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CELUM, Connie; GRINSZTEJN, Beatriz; NGURE, Kenneth. Preparing for long-acting PrEP delivery: building on lessons from oral PrEP. Journal of the International AIDS Society, Suppl. 2, 1-7, Jul. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60672
dc.identifier.issn.en_US.fl_str_mv 1758-2652
dc.identifier.doi.none.fl_str_mv 10.1002/jia2.26103
dc.identifier.eissn.none.fl_str_mv 1758-2652
identifier_str_mv CELUM, Connie; GRINSZTEJN, Beatriz; NGURE, Kenneth. Preparing for long-acting PrEP delivery: building on lessons from oral PrEP. Journal of the International AIDS Society, Suppl. 2, 1-7, Jul. 2023.
1758-2652
10.1002/jia2.26103
url https://www.arca.fiocruz.br/handle/icict/60672
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60672/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60672/2/ve_Connie_Celum_etal_INI_2023.pdf
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