Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response

Detalhes bibliográficos
Autor(a) principal: Albuquerque, Juliana Barreto de
Data de Publicação: 2018
Outros Autores: Santos, Danielle Silva dos, Stein, Jens V., Meis, Juliana de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31349
Resumo: University of Bern. Theodor Kocher Institute. Bern, Switzerland.
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spelling Albuquerque, Juliana Barreto deSantos, Danielle Silva dosStein, Jens V.Meis, Juliana de2019-01-29T16:35:19Z2019-01-29T16:35:19Z2018ALBUQUERQUE, Juliana Barreto de; et al. Oral versus intragastric inoculation: Similar Pathways of Trypanosoma cruzi experimental infection? From Target Tissues, Parasite evasion, and immune Response. Frontiers in Immunology, v.9, Article 1734, 9p, July 2018.https://www.arca.fiocruz.br/handle/icict/3134910.3389/fimmu.2018.017341664-3224engFrontiers MediaTrypanosoma cruziCavidade oralIinfecção intragástricaResposta imuneAtivação das Células TTrypanosoma cruzioral cavityintragastric infectionimmune responseT cell activationOral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Bern. Theodor Kocher Institute. Bern, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.University of Bern. Theodor Kocher Institute. Bern, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Currently, oral infection is the most frequent transmission mechanism of Chagas disease in Brazil and others Latin American countries. This transmission pathway presents increased mortality rate in the first 2 weeks, which is higher than the calculated mortality after the biting of infected insect vectors. Thus, the oral route of Trypanosoma cruzi infection, and the consequences in the host must be taken into account when thinking on the mechanisms underlying the natural history of the disease. Distinct routes of parasite entry may differentially affect immune circuits, stimulating regional immune responses that impact on the overall profile of the host protective immunity. Experimental studies related to oral infection usually comprise inoculation in the mouth (oral infection, OI) or gavage (gastrointestinal infection, GI), being often considered as similar routes of infection. Hence, establishing a relationship between the inoculation site (OI or GI) with disease progression and the mounting of T. cruzi-specific regional immune responses is an important issue to be considered. Here, we provide a discussion on studies performed in OI and GI in experimental models of acute infections, including T. cruzi infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31349/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdanieles_santos_etal_IOC_2018.pdfdanieles_santos_etal_IOC_2018.pdfapplication/pdf2467946https://www.arca.fiocruz.br/bitstream/icict/31349/2/danieles_santos_etal_IOC_2018.pdf9a3e75cc3a4eddc1823d8c694a9301d8MD52TEXTdanieles_santos_etal_IOC_2018.pdf.txtdanieles_santos_etal_IOC_2018.pdf.txtExtracted texttext/plain55942https://www.arca.fiocruz.br/bitstream/icict/31349/3/danieles_santos_etal_IOC_2018.pdf.txt6e36c38adcf8a63e177974dfea56e77bMD53icict/313492022-06-24 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dc.title.pt_BR.fl_str_mv Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
title Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
spellingShingle Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
Albuquerque, Juliana Barreto de
Trypanosoma cruzi
Cavidade oral
Iinfecção intragástrica
Resposta imune
Ativação das Células T
Trypanosoma cruzi
oral cavity
intragastric infection
immune response
T cell activation
title_short Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
title_full Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
title_fullStr Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
title_full_unstemmed Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
title_sort Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response
author Albuquerque, Juliana Barreto de
author_facet Albuquerque, Juliana Barreto de
Santos, Danielle Silva dos
Stein, Jens V.
Meis, Juliana de
author_role author
author2 Santos, Danielle Silva dos
Stein, Jens V.
Meis, Juliana de
author2_role author
author
author
dc.contributor.author.fl_str_mv Albuquerque, Juliana Barreto de
Santos, Danielle Silva dos
Stein, Jens V.
Meis, Juliana de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Cavidade oral
Iinfecção intragástrica
Resposta imune
Ativação das Células T
topic Trypanosoma cruzi
Cavidade oral
Iinfecção intragástrica
Resposta imune
Ativação das Células T
Trypanosoma cruzi
oral cavity
intragastric infection
immune response
T cell activation
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
oral cavity
intragastric infection
immune response
T cell activation
description University of Bern. Theodor Kocher Institute. Bern, Switzerland.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-29T16:35:19Z
dc.date.available.fl_str_mv 2019-01-29T16:35:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALBUQUERQUE, Juliana Barreto de; et al. Oral versus intragastric inoculation: Similar Pathways of Trypanosoma cruzi experimental infection? From Target Tissues, Parasite evasion, and immune Response. Frontiers in Immunology, v.9, Article 1734, 9p, July 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31349
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2018.01734
dc.identifier.eissn.none.fl_str_mv 1664-3224
identifier_str_mv ALBUQUERQUE, Juliana Barreto de; et al. Oral versus intragastric inoculation: Similar Pathways of Trypanosoma cruzi experimental infection? From Target Tissues, Parasite evasion, and immune Response. Frontiers in Immunology, v.9, Article 1734, 9p, July 2018.
10.3389/fimmu.2018.01734
1664-3224
url https://www.arca.fiocruz.br/handle/icict/31349
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31349/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31349/2/danieles_santos_etal_IOC_2018.pdf
https://www.arca.fiocruz.br/bitstream/icict/31349/3/danieles_santos_etal_IOC_2018.pdf.txt
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