Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains

Detalhes bibliográficos
Autor(a) principal: Bernardes-Engemann, Andréa Reis
Data de Publicação: 2022
Outros Autores: Tomki, Gabriela Ferreira, Rabello, Vanessa Brito de Souza, Almeida-Silva, Fernando, Freitas, Dayvison Francis Saraiva, Gutierrez-Galhardo, Maria Clara, Almeida-Paes, Rodrigo, Zancopé-Oliveira, Rosely Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55332
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
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spelling Bernardes-Engemann, Andréa ReisTomki, Gabriela FerreiraRabello, Vanessa Brito de SouzaAlmeida-Silva, FernandoFreitas, Dayvison Francis SaraivaGutierrez-Galhardo, Maria ClaraAlmeida-Paes, RodrigoZancopé-Oliveira, Rosely Maria2022-10-25T18:21:23Z2022-10-25T18:21:23Z2022BERNARDES-ENGEMANN, Andréa Reis et al. Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains. Frontiers in cellular and infection microbiology, v. 12, p. 1-8, 2022.2235-2988https://www.arca.fiocruz.br/handle/icict/5533210.3389/fcimb.2022.893501engFrontiers MediaSporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.The zoonotic transmission of sporotrichosis due to Sporothrix brasiliensis occurs largely in Rio de Janeiro state, Brazil since the 1990´s. Most patients infected with S. brasiliensis respond well to itraconazole or terbinafine. However, a few patients have a slow response or do not respond to the treatment and develop a chronic infection. The aim of this study was to analyze strains of S. brasiliensis against five different drugs to determine minimal inhibitory concentration distributions, to identify non-wild type strains to any drug evaluated and the clinical aspects of infections caused by them. This study evaluated 100 Sporothrix spp. strains obtained from 1999 to 2018 from the Evandro Chagas National Institute of Infectious Diseases, Fiocruz, which were identified through a polymerase chain reaction using specific primers for species identification. Two-fold serial dilutions of stock solutions of amphotericin B, itraconazole, posaconazole, ketoconazole and terbinafine prepared in dimethyl sulfoxide were performed to obtain working concentrations of antifungal drugs ranging from 0.015 to 8.0 mg/L. The broth microdilution reference method was performed according the M38-A2 CLSI guideline. All strains were identified as S. brasiliensis and thirteen were classified as non-wild type, two of them against different drugs. Non-wild type strains were identified throughout the entire study period. Patients infected by non-wild type strains presented prolonged treatment times, needed increased antifungal doses than those described in the literature and one of them presented a permanent sequel. In addition, three of them, with immunosuppression, died from sporotrichosis. Despite the broad use of antifungal drugs in hyperendemic areas of sporotrichosis, an emergence of non-wild type strains did not occur. The results of in vitro antifungal susceptibility tests should guide sporotrichosis therapy, especially in immunosuppressed patients.Sporothrix brasiliensisAntifungal drugsAntifungal susceptibilityNon-wild type strainSporotrichosisTreatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55332/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSporotrichosis_Andrea_Engemann_etal_INI_2022.pdfSporotrichosis_Andrea_Engemann_etal_INI_2022.pdfapplication/pdf580030https://www.arca.fiocruz.br/bitstream/icict/55332/2/Sporotrichosis_Andrea_Engemann_etal_INI_2022.pdfc13824269b1c6fcb90b7f3bb8dfecfe0MD52icict/553322022-10-25 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dc.title.en_US.fl_str_mv Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
title Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
spellingShingle Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
Bernardes-Engemann, Andréa Reis
Sporothrix brasiliensis
Antifungal drugs
Antifungal susceptibility
Non-wild type strain
Sporotrichosis
Treatment
title_short Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
title_full Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
title_fullStr Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
title_full_unstemmed Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
title_sort Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains
author Bernardes-Engemann, Andréa Reis
author_facet Bernardes-Engemann, Andréa Reis
Tomki, Gabriela Ferreira
Rabello, Vanessa Brito de Souza
Almeida-Silva, Fernando
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
author_role author
author2 Tomki, Gabriela Ferreira
Rabello, Vanessa Brito de Souza
Almeida-Silva, Fernando
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bernardes-Engemann, Andréa Reis
Tomki, Gabriela Ferreira
Rabello, Vanessa Brito de Souza
Almeida-Silva, Fernando
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
dc.subject.en.en_US.fl_str_mv Sporothrix brasiliensis
Antifungal drugs
Antifungal susceptibility
Non-wild type strain
Sporotrichosis
Treatment
topic Sporothrix brasiliensis
Antifungal drugs
Antifungal susceptibility
Non-wild type strain
Sporotrichosis
Treatment
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-25T18:21:23Z
dc.date.available.fl_str_mv 2022-10-25T18:21:23Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BERNARDES-ENGEMANN, Andréa Reis et al. Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains. Frontiers in cellular and infection microbiology, v. 12, p. 1-8, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55332
dc.identifier.issn.en_US.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2022.893501
identifier_str_mv BERNARDES-ENGEMANN, Andréa Reis et al. Sporotrichosis Caused by Non-Wild Type Sporothrix brasiliensis Strains. Frontiers in cellular and infection microbiology, v. 12, p. 1-8, 2022.
2235-2988
10.3389/fcimb.2022.893501
url https://www.arca.fiocruz.br/handle/icict/55332
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55332/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55332/2/Sporotrichosis_Andrea_Engemann_etal_INI_2022.pdf
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