Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis

Detalhes bibliográficos
Autor(a) principal: Poester, Vanice Rodrigues
Data de Publicação: 2022
Outros Autores: Basso, Rossana Patricia, Stevens, David A., Munhoz, Lívia Silveira, Rabello, Vanessa Brito de Souza, Almeida-Paes, Rodrigo, Zancopé-Oliveira, Rosely Maria, Zanchi, Mariza, Benelli, Jéssica Louise, Xavier, Melissa Orzechowski
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52660
Resumo: Universidade Federal do Rio Grande. Faculdade de Medicina. Programa de Pós Graduação em Ciências da Saúde. Rio Grande, RS, Brasil / Universidade Federal de Santa Maria. Programa de Pós Graduação em Bioquímica Toxicológica. Santa Maria, RS, Brasil / Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil.
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spelling Poester, Vanice RodriguesBasso, Rossana PatriciaStevens, David A.Munhoz, Lívia SilveiraRabello, Vanessa Brito de SouzaAlmeida-Paes, RodrigoZancopé-Oliveira, Rosely MariaZanchi, MarizaBenelli, Jéssica LouiseXavier, Melissa Orzechowski2022-05-13T14:37:10Z2022-05-13T14:37:10Z2022POESTER, Vanice Rodrigues et al. Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis. Journal of fungi, v. 8,1, p. 1-7, 20222309-608Xhttps://www.arca.fiocruz.br/handle/icict/5266010.3390/jof8010070engMDPITreatment of Human Sporotrichosis Caused by Sporothrix brasiliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande. Faculdade de Medicina. Programa de Pós Graduação em Ciências da Saúde. Rio Grande, RS, Brasil / Universidade Federal de Santa Maria. Programa de Pós Graduação em Bioquímica Toxicológica. Santa Maria, RS, Brasil / Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Faculdade de Medicina. Programa de Pós Graduação em Ciências da Saúde. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil / Hospital Universitário. Empresa Brasileira de Serviços Hospitalares. Rio Grande, RS, Brasil.California Institute for Medical Research San Jose, CA, USA / Stanford University Medical School. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, USA.Universidade Federal do Rio Grande. Faculdade de Medicina. Programa de Pós Graduação em Ciências da Saúde. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Hospital Universitário. Empresa Brasileira de Serviços Hospitalares. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil / Hospital Universitário. Empresa Brasileira de Serviços Hospitalares. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Faculdade de Medicina. Programa de Pós Graduação em Ciências da Saúde. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil.We describe the successful treatment of a series of 30 zoonotic sporotrichosis cases from southern Brazil. Sporothrix brasiliensis was the species genotypically identified in all 25 confirmed cases. Five other cases were classified as probable, without laboratory confirmation, but with clinical and epidemiological data of cat-transmitted sporotrichosis. Two isolates were sequenced by translation elongation factor-1 alpha (EF1α) loci in order to compare their sequences, and both of them showed distinct genotypes from S. brasiliensis strains from other Brazilian states. Itraconazole (ITZ) or potassium iodide (KI) were the first choice treatment in 28 and 2 cases, respectively. Microdilution assay showed a wild-type profile of S. brasiliensis isolates to ITZ. However, a lack of clinical response occurred in 42% of cases, especially those treated with ITZ 100 mg/day, and treatment needed modifications, by either increased doses or antifungal combinations. Clinical cure required a mean of 187 days of treatment, which was dependent on the clinical form of the disease and age of patients. Therapy, including dosages and durations, for cutaneous forms of sporotrichosis requires re-evaluation, since cases caused by S. brasiliensis may influence treatment efficacy.Sporothrix spp.Antifungal therapyItraconazolePotassium iodideZoonotic sporotrichosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/52660/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALTreatment_Vanessa_Rabello_etal_INI_2022.pdfTreatment_Vanessa_Rabello_etal_INI_2022.pdfapplication/pdf5225068https://www.arca.fiocruz.br/bitstream/icict/52660/2/Treatment_Vanessa_Rabello_etal_INI_2022.pdf44d7117eadd078a51593128deca4d5aaMD52icict/526602022-05-13 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dc.title.pt_BR.fl_str_mv Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
title Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
spellingShingle Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
Poester, Vanice Rodrigues
Sporothrix spp.
Antifungal therapy
Itraconazole
Potassium iodide
Zoonotic sporotrichosis
title_short Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
title_full Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
title_fullStr Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
title_full_unstemmed Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
title_sort Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis
author Poester, Vanice Rodrigues
author_facet Poester, Vanice Rodrigues
Basso, Rossana Patricia
Stevens, David A.
Munhoz, Lívia Silveira
Rabello, Vanessa Brito de Souza
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
Zanchi, Mariza
Benelli, Jéssica Louise
Xavier, Melissa Orzechowski
author_role author
author2 Basso, Rossana Patricia
Stevens, David A.
Munhoz, Lívia Silveira
Rabello, Vanessa Brito de Souza
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
Zanchi, Mariza
Benelli, Jéssica Louise
Xavier, Melissa Orzechowski
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Poester, Vanice Rodrigues
Basso, Rossana Patricia
Stevens, David A.
Munhoz, Lívia Silveira
Rabello, Vanessa Brito de Souza
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
Zanchi, Mariza
Benelli, Jéssica Louise
Xavier, Melissa Orzechowski
dc.subject.en.pt_BR.fl_str_mv Sporothrix spp.
Antifungal therapy
Itraconazole
Potassium iodide
Zoonotic sporotrichosis
topic Sporothrix spp.
Antifungal therapy
Itraconazole
Potassium iodide
Zoonotic sporotrichosis
description Universidade Federal do Rio Grande. Faculdade de Medicina. Programa de Pós Graduação em Ciências da Saúde. Rio Grande, RS, Brasil / Universidade Federal de Santa Maria. Programa de Pós Graduação em Bioquímica Toxicológica. Santa Maria, RS, Brasil / Universidade Federal do Rio Grande. Faculdade de Medicina. Laboratório de Micologia. Rio Grande, RS, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-05-13T14:37:10Z
dc.date.available.fl_str_mv 2022-05-13T14:37:10Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv POESTER, Vanice Rodrigues et al. Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis. Journal of fungi, v. 8,1, p. 1-7, 2022
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52660
dc.identifier.issn.pt_BR.fl_str_mv 2309-608X
dc.identifier.doi.none.fl_str_mv 10.3390/jof8010070
identifier_str_mv POESTER, Vanice Rodrigues et al. Treatment of Human Sporotrichosis Caused by Sporothrix brasiliensis. Journal of fungi, v. 8,1, p. 1-7, 2022
2309-608X
10.3390/jof8010070
url https://www.arca.fiocruz.br/handle/icict/52660
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52660/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/52660/2/Treatment_Vanessa_Rabello_etal_INI_2022.pdf
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