The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13830 |
Resumo: | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, Brasil / Faculdade Adventista da Bahia. Cachoeira, BA, Brasil |
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Machado, Marta Santos SerafimSilva, Hugo Bernardino FerreiraRios, RaimonOliveira, Anaque Pires deCarneiro, Noma Vilany QueirozCosta, Ryan dos SantosAlves, William SantosSouza, Fabio-Luis MenesesVelozo, Eudes da SilvaSouza, Silvana Alves deSilva, Tania Maria SarmentoSilva, Maria LenisePontes-de-Carvalho, Lain CarlosNeves, Neuza Maria AlcântaraFigueiredo, Camila Alexandrina Viana2016-04-15T17:26:57Z2016-04-15T17:26:57Z2015MACHADO, M. S. S. et al. The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. BMC Complementary & Alternative Medicine, v. 15, p. 168, 2015.1472-6882https://www.arca.fiocruz.br/handle/icict/1383010.1186/s12906-015-0702-8engBioMed CentralThe anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, Brasil / Faculdade Adventista da Bahia. Cachoeira, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilFaculdade Adventista da Bahia. Cachoeira, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilFaculdade Adventista da Bahia. Cachoeira, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Biologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, BrasilBACKGROUND: The prevalence of allergic diseases such as asthma has significantly increased worldwide, making it a public health concern. There is an urgent need for new anti-inflammatory agents with selective pharmacology and lower toxicity. Plant extracts have been used for centuries in traditional medicine to alleviate inflammatory diseases. In this work, we evaluated the anti-allergic activity of Cymbopogon citratus (Cy), a medicinal herb used by folk medicine to treat asthma. METHODS: We used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model. A/J mice were sensitized (100 µg/animal s.c.) and challenged (10 µg/animal i.n.) with Bt mite extract and treated with 60, 120 or 180 mg/kg of Cy standardized hexane extract. The parameters evaluated included: cellular infiltrate in bronchoalveolar lavage (BAL); eosinophil peroxidase activity (EPO); histopathological examination of the lung; serum levels of specific IgE, IgG1 and IgG2a; Th2 cytokine concentrations in BAL and expression of NF-κB. RESULTS: Our results showed that oral administration of a Cy hexane extract (especially 180 mg/Kg) reduced the numbers of leukocytes/eosinophils in BAL; the eosinophil peroxidase activity in BAL; the infiltration of leukocytes in lung tissue; the production of mucus in the respiratory tract; the level of IL-4 in BAL and the nuclear expression of NF-κB. CONCLUSIONS: The results presented demonstrate the potential of the Cy hexane extract to modulate allergic asthma; this extract may be an alternative future approach to treat this pathologyCymbopogon citratusAsthmaBlomia tropicalisNatural productsAntialérgicos/uso terapêuticoAnti-Inflamatórios/uso terapêuticoCymbopogonHipersensibilidade/quimioterapiaPulmão/efeitos de drogasNF-kappa B/metabolismoFitoterapiaAlérgenos/imunologiaAnimaisAntialérgicos/farmacologiaAnti-Inflamatórios/farmacologiaAsma/quimioterapiaLíquido da Lavagem Broncoalveolar/imunologiaCitocinas/metabolismoModelos Animais de DoençasPeroxidase de Eosinófilo/metabolismoEosinófilos/metabolismoHipersensibilidade/metabolismoInterleucina-4/imunologiaPulmão/metabolismoExtratos Vegetais/farmacologiaTransdução de Sinal/efeitos de drogasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| title |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| spellingShingle |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. Machado, Marta Santos Serafim Cymbopogon citratus Asthma Blomia tropicalis Natural products Antialérgicos/uso terapêutico Anti-Inflamatórios/uso terapêutico Cymbopogon Hipersensibilidade/quimioterapia Pulmão/efeitos de drogas NF-kappa B/metabolismo Fitoterapia Alérgenos/imunologia Animais Antialérgicos/farmacologia Anti-Inflamatórios/farmacologia Asma/quimioterapia Líquido da Lavagem Broncoalveolar/imunologia Citocinas/metabolismo Modelos Animais de Doenças Peroxidase de Eosinófilo/metabolismo Eosinófilos/metabolismo Hipersensibilidade/metabolismo Interleucina-4/imunologia Pulmão/metabolismo Extratos Vegetais/farmacologia Transdução de Sinal/efeitos de drogas |
| title_short |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| title_full |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| title_fullStr |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| title_full_unstemmed |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| title_sort |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. |
| author |
Machado, Marta Santos Serafim |
| author_facet |
Machado, Marta Santos Serafim Silva, Hugo Bernardino Ferreira Rios, Raimon Oliveira, Anaque Pires de Carneiro, Noma Vilany Queiroz Costa, Ryan dos Santos Alves, William Santos Souza, Fabio-Luis Meneses Velozo, Eudes da Silva Souza, Silvana Alves de Silva, Tania Maria Sarmento Silva, Maria Lenise Pontes-de-Carvalho, Lain Carlos Neves, Neuza Maria Alcântara Figueiredo, Camila Alexandrina Viana |
| author_role |
author |
| author2 |
Silva, Hugo Bernardino Ferreira Rios, Raimon Oliveira, Anaque Pires de Carneiro, Noma Vilany Queiroz Costa, Ryan dos Santos Alves, William Santos Souza, Fabio-Luis Meneses Velozo, Eudes da Silva Souza, Silvana Alves de Silva, Tania Maria Sarmento Silva, Maria Lenise Pontes-de-Carvalho, Lain Carlos Neves, Neuza Maria Alcântara Figueiredo, Camila Alexandrina Viana |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Machado, Marta Santos Serafim Silva, Hugo Bernardino Ferreira Rios, Raimon Oliveira, Anaque Pires de Carneiro, Noma Vilany Queiroz Costa, Ryan dos Santos Alves, William Santos Souza, Fabio-Luis Meneses Velozo, Eudes da Silva Souza, Silvana Alves de Silva, Tania Maria Sarmento Silva, Maria Lenise Pontes-de-Carvalho, Lain Carlos Neves, Neuza Maria Alcântara Figueiredo, Camila Alexandrina Viana |
| dc.subject.en.pt_BR.fl_str_mv |
Cymbopogon citratus Asthma Blomia tropicalis Natural products |
| topic |
Cymbopogon citratus Asthma Blomia tropicalis Natural products Antialérgicos/uso terapêutico Anti-Inflamatórios/uso terapêutico Cymbopogon Hipersensibilidade/quimioterapia Pulmão/efeitos de drogas NF-kappa B/metabolismo Fitoterapia Alérgenos/imunologia Animais Antialérgicos/farmacologia Anti-Inflamatórios/farmacologia Asma/quimioterapia Líquido da Lavagem Broncoalveolar/imunologia Citocinas/metabolismo Modelos Animais de Doenças Peroxidase de Eosinófilo/metabolismo Eosinófilos/metabolismo Hipersensibilidade/metabolismo Interleucina-4/imunologia Pulmão/metabolismo Extratos Vegetais/farmacologia Transdução de Sinal/efeitos de drogas |
| dc.subject.decs.pt_BR.fl_str_mv |
Antialérgicos/uso terapêutico Anti-Inflamatórios/uso terapêutico Cymbopogon Hipersensibilidade/quimioterapia Pulmão/efeitos de drogas NF-kappa B/metabolismo Fitoterapia Alérgenos/imunologia Animais Antialérgicos/farmacologia Anti-Inflamatórios/farmacologia Asma/quimioterapia Líquido da Lavagem Broncoalveolar/imunologia Citocinas/metabolismo Modelos Animais de Doenças Peroxidase de Eosinófilo/metabolismo Eosinófilos/metabolismo Hipersensibilidade/metabolismo Interleucina-4/imunologia Pulmão/metabolismo Extratos Vegetais/farmacologia Transdução de Sinal/efeitos de drogas |
| description |
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biorregulação. Salvador, BA, Brasil / Faculdade Adventista da Bahia. Cachoeira, BA, Brasil |
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2015 |
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2015 |
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2016-04-15T17:26:57Z |
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2016-04-15T17:26:57Z |
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info:eu-repo/semantics/article |
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MACHADO, M. S. S. et al. The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. BMC Complementary & Alternative Medicine, v. 15, p. 168, 2015. |
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https://www.arca.fiocruz.br/handle/icict/13830 |
| dc.identifier.issn.none.fl_str_mv |
1472-6882 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12906-015-0702-8 |
| identifier_str_mv |
MACHADO, M. S. S. et al. The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. BMC Complementary & Alternative Medicine, v. 15, p. 168, 2015. 1472-6882 10.1186/s12906-015-0702-8 |
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https://www.arca.fiocruz.br/handle/icict/13830 |
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eng |
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eng |
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BioMed Central |
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BioMed Central |
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