Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study

Detalhes bibliográficos
Autor(a) principal: Carneiro Neto, José Abraão
Data de Publicação: 2022
Outros Autores: Oliveira, Cássius José Vitor de, Ferraz, Sheila Nunes, Guerra, Mariele, Oliveira, Lívia Alves, Passos, Lúcia, Carvalho, Edgar M, Rocha, Paulo Novis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54860
Resumo: Conselho Nacional de Pesquisa (CNPq). Ministério da Ciência e Tecnologia. Fundação Maria Emília Freire Pedreira de Carvalho.
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spelling Carneiro Neto, José AbraãoOliveira, Cássius José Vitor deFerraz, Sheila NunesGuerra, MarieleOliveira, Lívia AlvesPassos, LúciaCarvalho, Edgar MRocha, Paulo Novis2022-09-23T18:33:23Z2022-09-23T18:33:23Z2022CARNEIRO NETO, José Abraão et al. Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study. Plos Neglected Tropical Diseases. V. 16, n. 1, p. 1-10, 2022.1935-2735https://www.arca.fiocruz.br/handle/icict/5486010.1371/journal.pntd.0009772Conselho Nacional de Pesquisa (CNPq). Ministério da Ciência e Tecnologia. Fundação Maria Emília Freire Pedreira de Carvalho.Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil.Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Universidade Federal da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Nefrologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil.Background: While bladder dysfunction is observed in the majority of patients with human T cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM), it is also observed in patients who do not fulfill all diagnostic criteria for HAM. These patients are classified as having possible or probable HAM/TSP. However, it remains unclear whether the severity and progression of bladder dysfunction occurs similarly between these two groups. Objective: Compare the severity and evolution of bladder dysfunction in HTLV-1-infected patients with possible and definite HAM/TSP. Methods: The present prospective cohort study followed 90 HTLV-1 patients with possible HAM/TSP and 84 with definite HAM/TSP between April 2011 and February 2019. Bladder dysfunction was evaluated by bladder diary, overactive bladder symptoms scores (OABSS) and urodynamic studies. Bladder dysfunction progression was defined as the need for clean self-intermittent catheterization (CIC). Results: At baseline, nocturia, urgency and OABSS scores were worse in definite compared to possible HAM/TSP patients. The main urodynamic finding was detrusor overactivity, present in 77.8% of the patients with definite HAM/TSP versus 58.7% of those with possible HAM/TSP (P = 0.05). Upon study conclusion, the cumulative frequency of patients requiring CIC increased in both groups, from 2 to 6 in possible HAM/TSP and from 28 to 44 in definite HAM/TSP patients. The estimated time to need for CIC was 6.7 years (95%CI 6.5-7.0) in the possible HAM/TSP group compared to 5.5 years (95%CI 4.8-6.1) in the definite HAM/TSP group. Conclusions: Although both groups showed similarities in bladder dysfunction and tended to progress to requiring CIC over time, patients with possible HAM/TSP presented less severe manifestations at baseline and progressed more slowly than those with definite HAM/TSP.engPublic Library of ScienceParaparesia Espástica TropicalVírus Linfotrópico T Tipo 1 HumanoBexiga urináriaParaparesis, Tropical SpasticHuman T-lymphotropic virus 1Urinary bladderBladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCarneiro Neto, José Brandão - Bladder dysfunction in human T cell lymphotropic virus infection.pdfCarneiro Neto, José Brandão - Bladder dysfunction in human T cell lymphotropic virus infection.pdfapplication/pdf587441https://www.arca.fiocruz.br/bitstream/icict/54860/2/Carneiro%20Neto%2c%20Jos%c3%a9%20Brand%c3%a3o%20-%20Bladder%20dysfunction%20in%20human%20T%20cell%20lymphotropic%20virus%20infection.pdf7dcbd4d11c7d890a1872425a4eab1853MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
title Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
spellingShingle Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
Carneiro Neto, José Abraão
Paraparesia Espástica Tropical
Vírus Linfotrópico T Tipo 1 Humano
Bexiga urinária
Paraparesis, Tropical Spastic
Human T-lymphotropic virus 1
Urinary bladder
title_short Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
title_full Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
title_fullStr Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
title_full_unstemmed Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
title_sort Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study
author Carneiro Neto, José Abraão
author_facet Carneiro Neto, José Abraão
Oliveira, Cássius José Vitor de
Ferraz, Sheila Nunes
Guerra, Mariele
Oliveira, Lívia Alves
Passos, Lúcia
Carvalho, Edgar M
Rocha, Paulo Novis
author_role author
author2 Oliveira, Cássius José Vitor de
Ferraz, Sheila Nunes
Guerra, Mariele
Oliveira, Lívia Alves
Passos, Lúcia
Carvalho, Edgar M
Rocha, Paulo Novis
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carneiro Neto, José Abraão
Oliveira, Cássius José Vitor de
Ferraz, Sheila Nunes
Guerra, Mariele
Oliveira, Lívia Alves
Passos, Lúcia
Carvalho, Edgar M
Rocha, Paulo Novis
dc.subject.other.en_US.fl_str_mv Paraparesia Espástica Tropical
Vírus Linfotrópico T Tipo 1 Humano
Bexiga urinária
topic Paraparesia Espástica Tropical
Vírus Linfotrópico T Tipo 1 Humano
Bexiga urinária
Paraparesis, Tropical Spastic
Human T-lymphotropic virus 1
Urinary bladder
dc.subject.en.en_US.fl_str_mv Paraparesis, Tropical Spastic
Human T-lymphotropic virus 1
Urinary bladder
description Conselho Nacional de Pesquisa (CNPq). Ministério da Ciência e Tecnologia. Fundação Maria Emília Freire Pedreira de Carvalho.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-23T18:33:23Z
dc.date.available.fl_str_mv 2022-09-23T18:33:23Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARNEIRO NETO, José Abraão et al. Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study. Plos Neglected Tropical Diseases. V. 16, n. 1, p. 1-10, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54860
dc.identifier.issn.en_US.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0009772
identifier_str_mv CARNEIRO NETO, José Abraão et al. Bladder dysfunction in human T cell lymphotropic virus infection: a prospective cohort study. Plos Neglected Tropical Diseases. V. 16, n. 1, p. 1-10, 2022.
1935-2735
10.1371/journal.pntd.0009772
url https://www.arca.fiocruz.br/handle/icict/54860
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54860/2/Carneiro%20Neto%2c%20Jos%c3%a9%20Brand%c3%a3o%20-%20Bladder%20dysfunction%20in%20human%20T%20cell%20lymphotropic%20virus%20infection.pdf
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