Evolutionary histories of expanded peptidase families in Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Silva, Larissa Lopes
Data de Publicação: 2011
Outros Autores: Marcet-Houben, Marina, Zerlotini, Adhemar, Gabaldón, Toni, Oliveira, Guilherme Corrêa, Nahum, Laila Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: http://dx.doi.org/10.1590/S0074-02762011000700013
https://www.arca.fiocruz.br/handle/icict/9340
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil
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spelling Silva, Larissa LopesMarcet-Houben, MarinaZerlotini, AdhemarGabaldón, ToniOliveira, Guilherme CorrêaNahum, Laila Alves2015-01-07T11:37:04Z2015-01-07T11:37:04Z2011SILVA, Larissa Lopes et al. Evolutionary histories of expanded peptidase families in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 77-864, 20110074-0276http://dx.doi.org/10.1590/S0074-02762011000700013https://www.arca.fiocruz.br/handle/icict/9340engFundação Oswaldo CruzEvolutionary histories of expanded peptidase families in Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, BrasilUniversitat Pompeu Fabra. Centre de Regulació Genòmica. Bioinformatics and Genomics Programme. Barcelona, SpainFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, BrasilUniversitat Pompeu Fabra. Centre de Regulació Genòmica. Bioinformatics and Genomics Programme. Barcelona, SpainFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, BrasilSchistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main virulence factors involved in the pathogenesis of this disease. In this context, evolutionary studies can be applied to identify peptidase families that have been expanded in genomes over time in response to different selection pressures. Using a phylogenomic approach, we searched for expanded endopeptidase families in the S. mansoni predicted proteome with the aim of contributing to the knowledge of such enzymes as potential therapeutic targets. We found three endopeptidase families that comprise leishmanolysins (metallopeptidase M8 family), cercarial elastases (serine peptidase S1 family) and cathepsin D proteins (aspartic peptidase A1 family). Our results suggest that the Schistosoma members of these families originated from successive gene duplication events in the parasite lineage after its diversification from other metazoans. Overall, critical residues are conserved among the duplicated genes/proteins. Furthermore, each protein family displays a distinct evolutionary history. Altogether, this work provides an evolutionary view of three S. mansoni peptidase families, which allows for a deeper understanding of the genomic complexity and lineage-specific adaptations potentially related to the parasitic lifestyle.phylogenomicsmaximum likelihood analysishomology predictionfunctional annotationproteasesparalogous familiesparasite genomicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9340/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALEvolutionary histories of expanded peptidase families in Schistosoma mansoni.pdfEvolutionary histories of expanded peptidase families in Schistosoma mansoni.pdfapplication/pdf4964978https://www.arca.fiocruz.br/bitstream/icict/9340/2/Evolutionary%20histories%20of%20expanded%20peptidase%20families%20in%20Schistosoma%20mansoni.pdff14c7b4746d8d73500b5499e5d919247MD52TEXTEvolutionary histories of expanded peptidase families in Schistosoma mansoni.pdf.txtEvolutionary histories of expanded peptidase families in Schistosoma mansoni.pdf.txtExtracted texttext/plain92136https://www.arca.fiocruz.br/bitstream/icict/9340/3/Evolutionary%20histories%20of%20expanded%20peptidase%20families%20in%20Schistosoma%20mansoni.pdf.txt392e2c5680e4782256312be7031065a6MD53icict/93402019-06-19 10:12:03.195oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:12:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evolutionary histories of expanded peptidase families in Schistosoma mansoni
title Evolutionary histories of expanded peptidase families in Schistosoma mansoni
spellingShingle Evolutionary histories of expanded peptidase families in Schistosoma mansoni
Silva, Larissa Lopes
phylogenomics
maximum likelihood analysis
homology prediction
functional annotation
proteases
paralogous families
parasite genomics
title_short Evolutionary histories of expanded peptidase families in Schistosoma mansoni
title_full Evolutionary histories of expanded peptidase families in Schistosoma mansoni
title_fullStr Evolutionary histories of expanded peptidase families in Schistosoma mansoni
title_full_unstemmed Evolutionary histories of expanded peptidase families in Schistosoma mansoni
title_sort Evolutionary histories of expanded peptidase families in Schistosoma mansoni
author Silva, Larissa Lopes
author_facet Silva, Larissa Lopes
Marcet-Houben, Marina
Zerlotini, Adhemar
Gabaldón, Toni
Oliveira, Guilherme Corrêa
Nahum, Laila Alves
author_role author
author2 Marcet-Houben, Marina
Zerlotini, Adhemar
Gabaldón, Toni
Oliveira, Guilherme Corrêa
Nahum, Laila Alves
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Larissa Lopes
Marcet-Houben, Marina
Zerlotini, Adhemar
Gabaldón, Toni
Oliveira, Guilherme Corrêa
Nahum, Laila Alves
dc.subject.en.pt_BR.fl_str_mv phylogenomics
maximum likelihood analysis
homology prediction
functional annotation
proteases
paralogous families
parasite genomics
topic phylogenomics
maximum likelihood analysis
homology prediction
functional annotation
proteases
paralogous families
parasite genomics
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2015-01-07T11:37:04Z
dc.date.available.fl_str_mv 2015-01-07T11:37:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SILVA, Larissa Lopes et al. Evolutionary histories of expanded peptidase families in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 77-864, 2011
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9340
dc.identifier.issn.none.fl_str_mv 0074-0276
http://dx.doi.org/10.1590/S0074-02762011000700013
identifier_str_mv SILVA, Larissa Lopes et al. Evolutionary histories of expanded peptidase families in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 77-864, 2011
0074-0276
url http://dx.doi.org/10.1590/S0074-02762011000700013
https://www.arca.fiocruz.br/handle/icict/9340
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
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