Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.

Detalhes bibliográficos
Autor(a) principal: Faria, Marcos Tucunduva de
Data de Publicação: 2007
Outros Autores: Athanazio, Daniel Abensur, Ramos, Eduardo Antônio Gonçalves, Silva, Edward Felix, Reis, Mitermayer Galvão dos, Ko, Albert Icksang
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7544
Resumo: Embrapa Amazonia Oriental. Belem, PA, Brasil
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spelling Faria, Marcos Tucunduva deAthanazio, Daniel AbensurRamos, Eduardo Antônio GonçalvesSilva, Edward FelixReis, Mitermayer Galvão dosKo, Albert Icksang2014-04-25T17:47:57Z2014-04-25T17:47:57Z2007FARIA, M. T. et al. Morphological alterations in the kidney of rats with natural and experimental Leptospira infection. Journal of Comparative Pathology, v. 137, n. 4, p. 231-238, 2007.0021-9975https://www.arca.fiocruz.br/handle/icict/754410.1016/j.jcpa.2007.08.001engElsevier Ltd.Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEmbrapa Amazonia Oriental. Belem, PA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil / Federal University of Pelotas. Pelotas, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Division of International Medicine and Infectious Disease.WeillMedical College of Cornell University. NewYork,NY,USALeptospirosis is a widespread anthropozoonosis, with a broad array of mammalian reservoirs, occurring as rural endemics, urban outbreaks related to floods, and emergent disease associated with water sports and recreational exposure in developed countries. Rats are the major source of human infection, particularly in urban areas; however few reports have focused on the pathology of leptospirosis in this host. This study reports pathological changes in 60 kidneys from captured wild rats and compares these with changes in the kidney of Wistar rats experimentally infected with Leptospira interrogans serovar Copenhageni strain FIOCRUZ L1-130. A broad range of morphological alterations were detected in the kidneys from captured rats but interstitial nephritis was the only feature reproduced under experimental conditions. The role of interstitial nephritis in the pathogenesis of leptospirosis is reviewed and it is suggested that rats may provide a potential tool for the study of colonization mechanisms and host resistance in acute leptospiral disease.leptospirosisRattus norvegicusInterstitial nephritiskidneyRim/patologiaLeptospira interrogansLeptospirose/patologiaLeptospirose/veterináriaDoenças dos Roedores/patologiaAnimaisModelos Animais de DoençasTécnica Indireta de Fluorescência para AnticorpoNefrite Intersticial/microbiologiaNefrite Intersticial/patologiaRatosRatos wistarinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFaria MT Morphological alterations....pdfFaria MT Morphological alterations....pdfapplication/pdf1419911https://www.arca.fiocruz.br/bitstream/icict/7544/1/Faria%20MT%20Morphological%20alterations....pdf782e1299445c48fa0874714687c6f544MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7544/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFaria MT Morphological alterations....pdf.txtFaria MT Morphological alterations....pdf.txtExtracted texttext/plain29845https://www.arca.fiocruz.br/bitstream/icict/7544/5/Faria%20MT%20Morphological%20alterations....pdf.txt50ea2cabdc4b826985555d6e6e45f460MD55THUMBNAILFaria MT Morphological alterations....pdf.jpgFaria MT Morphological alterations....pdf.jpgGenerated Thumbnailimage/jpeg2316https://www.arca.fiocruz.br/bitstream/icict/7544/4/Faria%20MT%20Morphological%20alterations....pdf.jpg05ff09431e06966ae1f11fade9f8cc7dMD54icict/75442023-03-15 14:33:12.619oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
title Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
spellingShingle Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
Faria, Marcos Tucunduva de
leptospirosis
Rattus norvegicus
Interstitial nephritis
kidney
Rim/patologia
Leptospira interrogans
Leptospirose/patologia
Leptospirose/veterinária
Doenças dos Roedores/patologia
Animais
Modelos Animais de Doenças
Técnica Indireta de Fluorescência para Anticorpo
Nefrite Intersticial/microbiologia
Nefrite Intersticial/patologia
Ratos
Ratos wistar
title_short Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
title_full Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
title_fullStr Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
title_full_unstemmed Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
title_sort Morphological alterations in the kidney of rats with natural and experimental Leptospira infection.
author Faria, Marcos Tucunduva de
author_facet Faria, Marcos Tucunduva de
Athanazio, Daniel Abensur
Ramos, Eduardo Antônio Gonçalves
Silva, Edward Felix
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
author_role author
author2 Athanazio, Daniel Abensur
Ramos, Eduardo Antônio Gonçalves
Silva, Edward Felix
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Faria, Marcos Tucunduva de
Athanazio, Daniel Abensur
Ramos, Eduardo Antônio Gonçalves
Silva, Edward Felix
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
dc.subject.en.pt_BR.fl_str_mv leptospirosis
Rattus norvegicus
Interstitial nephritis
kidney
topic leptospirosis
Rattus norvegicus
Interstitial nephritis
kidney
Rim/patologia
Leptospira interrogans
Leptospirose/patologia
Leptospirose/veterinária
Doenças dos Roedores/patologia
Animais
Modelos Animais de Doenças
Técnica Indireta de Fluorescência para Anticorpo
Nefrite Intersticial/microbiologia
Nefrite Intersticial/patologia
Ratos
Ratos wistar
dc.subject.decs.pt_BR.fl_str_mv Rim/patologia
Leptospira interrogans
Leptospirose/patologia
Leptospirose/veterinária
Doenças dos Roedores/patologia
Animais
Modelos Animais de Doenças
Técnica Indireta de Fluorescência para Anticorpo
Nefrite Intersticial/microbiologia
Nefrite Intersticial/patologia
Ratos
Ratos wistar
description Embrapa Amazonia Oriental. Belem, PA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-04-25T17:47:57Z
dc.date.available.fl_str_mv 2014-04-25T17:47:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FARIA, M. T. et al. Morphological alterations in the kidney of rats with natural and experimental Leptospira infection. Journal of Comparative Pathology, v. 137, n. 4, p. 231-238, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7544
dc.identifier.issn.none.fl_str_mv 0021-9975
dc.identifier.doi.none.fl_str_mv 10.1016/j.jcpa.2007.08.001
identifier_str_mv FARIA, M. T. et al. Morphological alterations in the kidney of rats with natural and experimental Leptospira infection. Journal of Comparative Pathology, v. 137, n. 4, p. 231-238, 2007.
0021-9975
10.1016/j.jcpa.2007.08.001
url https://www.arca.fiocruz.br/handle/icict/7544
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Ltd.
publisher.none.fl_str_mv Elsevier Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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