Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49847 |
Resumo: | a Brain Institute (BraIns), Pontificia Universidade Cat´ olica do Rio Grande do Sul, Porto Alegre, RS, Brazil b Center for Biotechnology and Cell Therapy, Sao ˜ Rafael Hospital, Bahia, Brazil c D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil d Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Bahia, Brazil e Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil |
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Costa-Ferro, Zaquer Suzana MunhozLima, Pedro Antônio Schmidt do PradoOnsten, Guilherme AryOliveira, Gutierre NevesBrito, Guilherme CamargoGhilardi, Isadora MachadoSantos, Paula Gabrielli dosBertinatto, Ricardo JeanSilva, Daniele Vieira daSalamoni, Simone DeniseMachado, Denise CantarelliCruz, Ivana Beatrice Mânica daSouza, Bruno Solano de FreitasCosta, Jaderson Costa da2021-11-16T18:01:04Z2021-11-16T18:01:04Z2021COSTA-FERRO, Zaquer Suzana Munhoz et al. Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 113, 2021.0278-5846https://www.arca.fiocruz.br/handle/icict/4984710.1016/j.pnpbp.2021.110455a Brain Institute (BraIns), Pontificia Universidade Cat´ olica do Rio Grande do Sul, Porto Alegre, RS, Brazil b Center for Biotechnology and Cell Therapy, Sao ˜ Rafael Hospital, Bahia, Brazil c D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil d Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Bahia, Brazil e Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, BrazilCNPq, FAPERGS, PUCRS, and Pandurata Alimentos Ltda. The funding organizations played no role in the design or conduct of the study, data interpretation, or article writing. Jaderson Costa da Costa is funded by CNPq (research productivity, PQ1A)."Múltipla ver em Notas"Introduction: Major depressive disorder is associated with chronic inflammation and deficient production of brain-derived neurotrophic factor (BDNF). Bone marrow mononuclear cell (BMMC) transplantation has an antiinflammatory effect and has been proven effective in restoring non-depressive behavior. This study investigated whether BMMC transplantation can prevent the development of depression or anxiety in chronic mild stress (CMS), as well as its effect on inflammatory and neurogenic molecules. Method: Three groups of animals were compared: BMMC-transplanted animals subjected to CMS for 45 days, CMS non-transplanted rats, and control animals. After the CMS period, the three groups underwent the following behavioral tests: sucrose preference test (SPT), eating-related depression test (ERDT), social avoidance test (SAT), social interaction test (SIT), and elevated plus maze test (EPMT). Transplanted cell tracking and measurement of the expression of high-mobility group box 1 (HMGB1), interleukin-1β (IL-1β), tumor necrosis factor (TNFα), and BDNF were performed on brain and spleen tissues. Results: BMMC transplantation prevented the effects of CMS in the SPT, ERDT, SAT, and SIT, while prevention was less pronounced in the EPMT. It was found to prevent increased HMGB-1 expression induced by CMS in the hippocampus and spleen, increase BDNF expression in both tissues, and prevent increased IL-1β expression in the hippocampus alone, while no effect of the transplant was observed in the TNFα expression. In addition, no transplanted cells were found in either the brain or spleen. Conclusions: BMMC transplantation prevents the development of depression and anxiety-like behavior triggered by CMS. It could prevent increased HMGB-1 and IL-1β expression in the hippocampus and increased BDNF expression in the same tissue. Cell treatment represents a further perspective in the research and treatment of depression and possible mood disorders.engElsevierCélulas mononuclearesMedula ósseaTansplantaçãoInflamaçãoDepressãoTratamentoBone marrow mononuclear cellsTransplantationDepression treatmentHMGB1BDNFInflammationBone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic moleculesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49847/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCosta-Ferro, Zaquer Suzana Munhoz Bone marrow....pdfCosta-Ferro, Zaquer Suzana Munhoz Bone marrow....pdfapplication/pdf1342872https://www.arca.fiocruz.br/bitstream/icict/49847/2/Costa-Ferro%2c%20%20Zaquer%20Suzana%20Munhoz%20Bone%20marrow....pdf9d7a7fd7db50845cdaa8ea9942b40de7MD52icict/498472023-03-15 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| dc.title.pt_BR.fl_str_mv |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| title |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| spellingShingle |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules Costa-Ferro, Zaquer Suzana Munhoz Células mononucleares Medula óssea Tansplantação Inflamação Depressão Tratamento Bone marrow mononuclear cells Transplantation Depression treatment HMGB1 BDNF Inflammation |
| title_short |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| title_full |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| title_fullStr |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| title_full_unstemmed |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| title_sort |
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules |
| author |
Costa-Ferro, Zaquer Suzana Munhoz |
| author_facet |
Costa-Ferro, Zaquer Suzana Munhoz Lima, Pedro Antônio Schmidt do Prado Onsten, Guilherme Ary Oliveira, Gutierre Neves Brito, Guilherme Camargo Ghilardi, Isadora Machado Santos, Paula Gabrielli dos Bertinatto, Ricardo Jean Silva, Daniele Vieira da Salamoni, Simone Denise Machado, Denise Cantarelli Cruz, Ivana Beatrice Mânica da Souza, Bruno Solano de Freitas Costa, Jaderson Costa da |
| author_role |
author |
| author2 |
Lima, Pedro Antônio Schmidt do Prado Onsten, Guilherme Ary Oliveira, Gutierre Neves Brito, Guilherme Camargo Ghilardi, Isadora Machado Santos, Paula Gabrielli dos Bertinatto, Ricardo Jean Silva, Daniele Vieira da Salamoni, Simone Denise Machado, Denise Cantarelli Cruz, Ivana Beatrice Mânica da Souza, Bruno Solano de Freitas Costa, Jaderson Costa da |
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author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa-Ferro, Zaquer Suzana Munhoz Lima, Pedro Antônio Schmidt do Prado Onsten, Guilherme Ary Oliveira, Gutierre Neves Brito, Guilherme Camargo Ghilardi, Isadora Machado Santos, Paula Gabrielli dos Bertinatto, Ricardo Jean Silva, Daniele Vieira da Salamoni, Simone Denise Machado, Denise Cantarelli Cruz, Ivana Beatrice Mânica da Souza, Bruno Solano de Freitas Costa, Jaderson Costa da |
| dc.subject.other.pt_BR.fl_str_mv |
Células mononucleares Medula óssea Tansplantação Inflamação Depressão Tratamento |
| topic |
Células mononucleares Medula óssea Tansplantação Inflamação Depressão Tratamento Bone marrow mononuclear cells Transplantation Depression treatment HMGB1 BDNF Inflammation |
| dc.subject.en.pt_BR.fl_str_mv |
Bone marrow mononuclear cells Transplantation Depression treatment HMGB1 BDNF Inflammation |
| description |
a Brain Institute (BraIns), Pontificia Universidade Cat´ olica do Rio Grande do Sul, Porto Alegre, RS, Brazil b Center for Biotechnology and Cell Therapy, Sao ˜ Rafael Hospital, Bahia, Brazil c D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil d Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Bahia, Brazil e Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil |
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2021 |
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2021-11-16T18:01:04Z |
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2021-11-16T18:01:04Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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COSTA-FERRO, Zaquer Suzana Munhoz et al. Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 113, 2021. |
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https://www.arca.fiocruz.br/handle/icict/49847 |
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0278-5846 |
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10.1016/j.pnpbp.2021.110455 |
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COSTA-FERRO, Zaquer Suzana Munhoz et al. Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 113, 2021. 0278-5846 10.1016/j.pnpbp.2021.110455 |
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