Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients

Detalhes bibliográficos
Autor(a) principal: Fievez, Aline Mireille da Cunha
Data de Publicação: 2019
Outros Autores: Freitas, Maria Luciana Silva, Sousa, Anastácio de Queiroz, Oliveira, Joanna R. Santos, Cruz, Alda M. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35354
Resumo: Universidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
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spelling Fievez, Aline Mireille da CunhaFreitas, Maria Luciana SilvaSousa, Anastácio de QueirozOliveira, Joanna R. SantosCruz, Alda M. da2019-09-05T14:12:35Z2019-09-05T14:12:35Z2019FIEVEZ, Aline Mireille da Cunha et al. Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients. Plos One, v. 14, n. 3, p. 1-15, Mar. 2019.1932-6203https://www.arca.fiocruz.br/handle/icict/3535410.1371/journal.pone.0214413engPublic Library of ScienceNíveis baixosLeptinaParâmetrosLeishmaniose visceralPacientesVisceral LeishmaniasisLeptinPatientsParametersLower levelsLower levels of leptin are associated with severity parameters in visceral leishmaniasis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasilniversidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia. Núcleo de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Ri de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Ri de Janeiro, RJ, Brasil.Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, and if untreated may be fatal. It affects important organs of the immune system and is characterized by a specific immunosuppression, along with intense cellular activation and cytokine storm. Moreover, VL is now recognized as a systemic inflammatory response syndrome (SIRS), in which multiple cytokines and other pro-inflammatory molecules are released. The action of these inflammatory mediators may be considered risk factors for poor prognosis and death. Leptin, a hormone derived from adipose tissue, has been described with several immunoregulatory functions in vitro and in vivo Leishmania infection models, particularly for enhancing the macrophage microbicidal mechanisms. Considering that evaluation of immunologic parameters that may be associated with this clinical scenario may help to decrease VL lethality, we evaluated whether leptin is associated with VL pathogenesis. Thirty-one patients were recruited in the active phase of VL, of which 22 were followed up until one month after therapy (1mpt). Except for creatinine levels, all clinical parameters were altered in active VL patients, especially leucocyte counts and albumin and hemoglobin levels. Also, elevated levels of lipopolysaccharide (LPS), immunoglobulins (Ig)G1 and G3 anti-Leishmania and interleukins (IL)-6 and -10 were higher than in healthy individuals. In contrast, active VL patients presented diminished serum leptin levels and positive correlation with leukocytes counts and hemoglobin and albumin levels. After 1mpt, VL patients showed a significant increase in leptin levels, reaching values similar to healthy volunteers. As expected, only LPS levels remained elevated after 1mpt. These findings suggest that leptin levels are affected in Leishmania infection and the correlation with important parameters associated with the prognosis of VL points to the involvement of this molecule in VL immunopathogenesis. Additional studies are needed to evaluate the possibility of leptin as a prognostic marker of VL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35354/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaLFreitas_AldaMCruz_etal_IOC_2019.pdfMariaLFreitas_AldaMCruz_etal_IOC_2019.pdfapplication/pdf2042927https://www.arca.fiocruz.br/bitstream/icict/35354/2/MariaLFreitas_AldaMCruz_etal_IOC_2019.pdf26496e11aca9aaaf779c0b1f74d84c8bMD52TEXTMariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txtMariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txtExtracted texttext/plain45151https://www.arca.fiocruz.br/bitstream/icict/35354/3/MariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txt21a06a8b2c4cb67d75159b9227484e52MD53icict/353542019-09-06 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dc.title.pt_BR.fl_str_mv Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
title Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
spellingShingle Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
Fievez, Aline Mireille da Cunha
Níveis baixos
Leptina
Parâmetros
Leishmaniose visceral
Pacientes
Visceral Leishmaniasis
Leptin
Patients
Parameters
Lower levels
title_short Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
title_full Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
title_fullStr Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
title_full_unstemmed Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
title_sort Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
author Fievez, Aline Mireille da Cunha
author_facet Fievez, Aline Mireille da Cunha
Freitas, Maria Luciana Silva
Sousa, Anastácio de Queiroz
Oliveira, Joanna R. Santos
Cruz, Alda M. da
author_role author
author2 Freitas, Maria Luciana Silva
Sousa, Anastácio de Queiroz
Oliveira, Joanna R. Santos
Cruz, Alda M. da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Fievez, Aline Mireille da Cunha
Freitas, Maria Luciana Silva
Sousa, Anastácio de Queiroz
Oliveira, Joanna R. Santos
Cruz, Alda M. da
dc.subject.other.pt_BR.fl_str_mv Níveis baixos
Leptina
Parâmetros
Leishmaniose visceral
Pacientes
topic Níveis baixos
Leptina
Parâmetros
Leishmaniose visceral
Pacientes
Visceral Leishmaniasis
Leptin
Patients
Parameters
Lower levels
dc.subject.en.pt_BR.fl_str_mv Visceral Leishmaniasis
Leptin
Patients
Parameters
Lower levels
description Universidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-05T14:12:35Z
dc.date.available.fl_str_mv 2019-09-05T14:12:35Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIEVEZ, Aline Mireille da Cunha et al. Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients. Plos One, v. 14, n. 3, p. 1-15, Mar. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35354
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0214413
identifier_str_mv FIEVEZ, Aline Mireille da Cunha et al. Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients. Plos One, v. 14, n. 3, p. 1-15, Mar. 2019.
1932-6203
10.1371/journal.pone.0214413
url https://www.arca.fiocruz.br/handle/icict/35354
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35354/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/35354/2/MariaLFreitas_AldaMCruz_etal_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/35354/3/MariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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